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ALPK2 identified as promising new therapeutic target for treatment of heart failure

Tatsuya Yoshida, Mikito Takefuji, and Toyoaki Murohara in the Department of Cardiology, Nagoya University Graduate School of Medicine, identified an enzyme, alpha-kinase 2 (ALPK2) that is specifically expressed in the heart.

30 Jan 2025

Stem cell-derived heart patches show promise for heart failure treatment

Innovative muscle patches derived from stem cells demonstrate efficacy in heart repair, improving function in primates and a human patient, with trials ahead.

30 Jan 2025

Cancer-fighting virus T-VEC helps shrink tough-to-treat skin tumors

Talimogene laherparepvec (T-VEC) demonstrates efficacy in cutaneous BCC, enhancing resectability and altering immune cell composition with low adverse events.

30 Jan 2025

The key to healthy aging? Exercise might be the answer

Researchers explore the health benefits of physical activity in the elderly.

30 Jan 2025

New compound Z526 combats cancer-associated cachexia in preclinical models

In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

29 Jan 2025

New treatment identified for peripheral nerve sheath tumors

A multicenter collaboration led by the Bellvitge Biomedical Research Institute (IDIBELL) - Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research Institute (IGTP) identified a potential new treatment for an aggressive sarcoma arising in the nerves.

28 Jan 2025

Exercise improves brain insulin sensitivity and lowers dementia risk in older adults with prediabetes

Researchers explore the impact of exercise on the short-term regulation of insulin pathways in brain circuits.

28 Jan 2025

New brain biomarker identifies pain sensitivity and may predict chronic pain risk

A novel biomarker signature combining PAF and CME predicts chronic pain risk, linking brain activity to individual pain sensitivity and treatment strategies.

28 Jan 2025

Fewer anesthesiology residents applying to US pain medicine fellowships

The study highlights a concerning 45% decline in pain medicine fellowship applications, pointing to workforce issues and gender disparities in anesthesiology.

28 Jan 2025

HMB supplement trial explores new treatment for chronic liver disease

A dietary supplement used to build muscle – or prevent muscle loss as a result of ageing or illness – is to be trialled as a potential treatment for chronic liver disease.

28 Jan 2025

Study reveals the importance of physical activity for healthy aging

Can physical activity extend the lifespans of older adults? A review article published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.231336 summarizes the considerable evidence supporting the important role physical activity plays in preventing or reducing the effects of diseases and discusses how to prescribe effective exercise for older adults.

27 Jan 2025

Ross procedure offers durable results in young patients

Young patients who have undergone the Ross procedure for aortic valve disease have shown excellent long-term survival, the majority without the need for additional surgery two decades later.

27 Jan 2025

Online app supports weight loss through protein and fiber tracking

Many people struggle to maintain a healthy weight, and choosing the optimal meals for weight loss can be challenging.

24 Jan 2025

Research could lead to better medicines and new tools in synthetic biology

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their function, shaping their structure and interactions.

24 Jan 2025

Boosting BCL6 may counteract muscle loss from GLP-1 medications

About one in eight adults in the United States has tried or currently uses a GLP-1 medication, and a quarter of those users cite weight loss as their main goal.

23 Jan 2025

New diagnostic device could enable at-home early bladder cancer detection

Innovative fluorescence-based diagnostic system identifies early-stage bladder cancer with 90% accuracy, utilizing untreated urine samples for at-home testing.

23 Jan 2025

Researchers develop mRNA-based blood clots to treat osteoarthritis

University of Wisconsin–Madison researchers have developed a promising technique for treating osteoarthritis using therapeutic blood clots activated by messenger RNA.

22 Jan 2025

KTU develops adaptive rehabilitation system for personalized recovery

In today's healthcare environment, there is an increasing focus on improving the efficiency of rehabilitation processes, given the rising number of injuries and the need to return to active life more quickly.

22 Jan 2025

Turmeric and curcumin may reduce muscle damage, inflammation after exercise

The turmeric plant, a member of the ginger family, has been used as a spice or food dye in cooking for thousands of years.

22 Jan 2025

Muscle fat infiltration predicts heart disease risk better than BMI, study finds

Skeletal muscle fat infiltration (IMAT) is linked to coronary microvascular dysfunction and increased cardiovascular risk, independent of BMI and traditional risk factors.

21 Jan 2025