Pathogen News and Research

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Understanding endemic and novel zoonotic spillovers from rodent trapping studies

The global impact of novel zoonotic pathogen spillovers has been highlighted through the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the rapid outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. In the past, similar effects were recorded during the HIV/AIDs and Spanish Influenza pandemics.

24 Jan 2023

Transient gut infection influences hosts’ adaptation to nutrient restriction

Transient gut infection not only promotes white adipose tissue expansion and host weight gain but also optimizes host metabolism for carbohydrates.

23 Jan 2023

Exploring the clinical impact of co-detections of other respiratory viruses in US children hospitalized for COVID-19

Researchers recently assessed the clinical impact and epidemiology of viral co-detections in children in the United States of America (USA) during the coronavirus disease 2019 (COVID-19) pandemic.

23 Jan 2023

State-of-the-art Biocontainment Unit opened at MedStar Washington Hospital Center

MedStar Washington Hospital Center has opened a state-of-the-art Biocontainment Unit that will be used primarily for observation and flexed for respiratory isolation and further flexed to care for patients with highly infectious diseases.

19 Jan 2023

Comprehensive analysis of genome sequences unravels the elusive origins of bubonic plague

Seeking to better understand more about the origins and movement of bubonic plague, in ancient and contemporary times, researchers at McMaster University, University of Sydney and the University of Melbourne, have completed a painstaking granular examination of hundreds of modern and ancient genome sequences, creating the largest analysis of its kind.

19 Jan 2023

Study sheds new light on how the B cell academy mounts a diverse immune response

Cells jostling for a spot in a germinal center face a cutthroat admissions process. Formed after exposure to a pathogen or vaccine, germinal centers act as a kind of immune system training academy, helping B cells refine their response to the threat.

18 Jan 2023

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

A new study describes that tight transmission bottlenecks restrict the evolution of SARS-CoV-2 in the transmission chain. SARS-CoV-2 is the causative pathogen of the COVID-19 pandemic.

18 Jan 2023

Exploring a novel amplicon-based mpox virus sequencing strategy

Researchers described the development of a sequencing strategy based on amplicons for mpox detection.

18 Jan 2023

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

A promising approach to control Staphylococcus aureus bacterial colonization in people - using a probiotic instead of antibiotics - was safe and highly effective in a Phase 2 clinical trial.

17 Jan 2023

Researchers report on the largest cohort of patients tested using plasma mcfDNA sequencing for pathogen detection

Researchers identified a wide variety of pathogenic organisms using plasma mcfDNA sequencing.

16 Jan 2023

The trajectory of CD4+ T cell responses to mRNA vaccines in older individuals

Researchers investigated how age-related T-cell defects impacted the effectiveness of mRNA-based COVID-19 vaccines.

16 Jan 2023

Researchers analyze the ancestry components in modern and historic VARV genomes

A recent study published in Microbial Genomics analyzed the molecular evolution of the variola virus (VARV)

13 Jan 2023

The impact of early life microbial colonization and respiratory diseases on the respiratory microbiome

Researchers reviewed the impact of the interactions between the respiratory microbiota and the immune system.

13 Jan 2023

New research identifies natural compounds with pan-SARS-CoV-2 inhibitory activity

Scientists have recently conducted a cell-based high-content screening of over 300 natural compounds and identified three compounds with potent antiviral activities against SARS-CoV-2 and its variants.

12 Jan 2023

What is the impact of antibiotic exposure on the risk of inflammatory bowel disease?

Researchers evaluated the impact of antibiotic usage on IBD development risk among individuals aged ten years and above.

12 Jan 2023

Waning immunity hypothesis may explain mumps resurgence in the United States

Researchers investigated the putative mechanism(s) of vaccine failure underlying the resurgence of mumps in the United States (US).

11 Jan 2023

Wellcome Sanger Institute launches new initiative to better understand respiratory viruses

A new initiative to better understand respiratory viruses has been launched today (10 January 2023) by the Wellcome Sanger Institute.

10 Jan 2023

What is the long-term cognitive impact of COVID-19, and what are its predictors?

Scientists have described demographic and clinical predictors of cognitive dysfunction and self-perceived cognitive difficulties in COVID-19 survivors one-year after infection.

9 Jan 2023

COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants

In a recent study posted to bioRxiv*, researchers designed a nanoparticle (NP)-conjugated toll-like receptor 9 (TLR9) agonist to improve the adjuvanticity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

8 Jan 2023

New model for detecting and estimating pathogen variant dynamics and risk

A recent study posted to the medRxiv* preprint server developed a hierarchical modeling method to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant fitness advantage and prevalence.

8 Jan 2023

Pathogen News and Research

Understanding endemic and novel zoonotic spillovers from rodent trapping studies

Transient gut infection influences hosts’ adaptation to nutrient restriction

Exploring the clinical impact of co-detections of other respiratory viruses in US children hospitalized for COVID-19

State-of-the-art Biocontainment Unit opened at MedStar Washington Hospital Center

Comprehensive analysis of genome sequences unravels the elusive origins of bubonic plague

Study sheds new light on how the B cell academy mounts a diverse immune response

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

Exploring a novel amplicon-based mpox virus sequencing strategy

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

Researchers report on the largest cohort of patients tested using plasma mcfDNA sequencing for pathogen detection

The trajectory of CD4+ T cell responses to mRNA vaccines in older individuals

Researchers analyze the ancestry components in modern and historic VARV genomes

The impact of early life microbial colonization and respiratory diseases on the respiratory microbiome

New research identifies natural compounds with pan-SARS-CoV-2 inhibitory activity

What is the impact of antibiotic exposure on the risk of inflammatory bowel disease?

Waning immunity hypothesis may explain mumps resurgence in the United States

Wellcome Sanger Institute launches new initiative to better understand respiratory viruses

What is the long-term cognitive impact of COVID-19, and what are its predictors?

COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants

New model for detecting and estimating pathogen variant dynamics and risk

Best practices - optimize qPCR processes for pathogen detection eBook

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