immunity News and Research

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Adenine base editors show potential to correct X-CGD-causing mutations

A collaborative effort between investigators at the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) and Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder characterized by high susceptibility to infections.

16 Oct 2024

Distinct immune profiles linked to adverse reactions from immunotherapy

Distinct immune "signatures" in patients who develop adverse events while taking immunotherapy for cancer may help oncologists identify patients at risk and treat them early to prevent serious side effects, suggests a study by researchers from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

15 Oct 2024

New study reveals mechanism of inflammation in lupus

Immune cells called monocytes produce a key inflammatory protein called interleukin-1 beta (IL-1β) through an unconventional pathway in patients with systemic lupus erythematosus, commonly referred to as lupus, according to a new study by Weill Cornell Medicine investigators.

15 Oct 2024

New insights into pain mechanisms related to viral infections

An article published in the journal Brain, Behavior, and Immunity reports the findings of a study by researchers based in Brazil, the United States and South Korea who set out to understand how viral infections cause pain and to contribute to the search for novel ways of relieving it.

15 Oct 2024

Naloxone use by non-medical bystanders on the rise, but not fast enough

Use of a lifesaving drug to reverse opioid drug overdoses is growing, but not fast enough. That's according to new research in JAMA Network Open from The Ohio State University College of Medicine, College of Public Health and the National Registry of Emergency Medical Technicians.

14 Oct 2024

De novo antibody protein sequencing reveals novel functional and neutralizing antibodies post-SARS-CoV-2 vaccination

Rapid Novor has published a study that highlights the power of combining de novo antibody protein sequencing with conventional proteomics to uncover functional and neutralizing antibodies in human plasma following SARS-CoV-2 vaccination.

From Rapid Novor Inc 14 Oct 2024

Gaza aims for 90% vaccination coverage in second round of polio campaign

The second round of an emergency polio vaccination campaign is scheduled to start on 14 October 2024 in Gaza, to vaccinate an estimated 591,700 children under ten years of age with a second dose of the novel oral polio vaccine type 2 (nOPV2) vaccine.

14 Oct 2024

Chronic stress disrupts gut microbiota, promoting colorectal cancer growth

Cutting-edge research has uncovered how chronic stress disrupts the balance of gut microbiota to speed up the progression of colorectal cancer (CRC), opening new avenues for CRC prevention and treatment.

13 Oct 2024

How gut microbiome and fiber diversity shape chronic disease outcomes

Review explores how different types of dietary fibers interact with the gut microbiome, influencing chronic disease risks like obesity, cancer, and cardiometabolic conditions, while emphasizing the need for personalized dietary interventions.

13 Oct 2024

Researchers uncover mechanism of protein GBP1 in immune defense

The protein GBP1 is a vital component of our body's natural defence against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now.

12 Oct 2024

Researchers develop innovative mouse model for studying cancer immunotherapy

Immunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells - by using engineered antibodies - or by simply providing it with new cells, pre-equipped to search and destroy cancer.

12 Oct 2024

Heat stress impacts development of babies during critical early years

Exposure to high levels of heat may both impact the growth of fetuses during pregnancy and infants up to the age of two, a new analysis suggests.

8 Oct 2024

FAU researchers highlight new vaccination barriers

Vaccines to prevent common and serious infectious diseases have had a greater impact on improving human health than any other medical advance of the 20th century, surpassing even sanitation and potable water. From the global eradication of smallpox in 1980 to the unprecedented development of effective and safe mRNA vaccines for COVID-19, vaccinations have played crucial roles in preventing millions of premature deaths and hospitalizations in adults and children.

8 Oct 2024

UMass Amherst researcher receives $2.2 million grant to study tuberculosis response

The National Institutes of Health recently awarded $2.2 million to Alissa Rothchild, assistant professor in the Department of Veterinary and Animal Sciences at the University of Massachusetts Amherst and an expert in tuberculosis (TB) immunology, to study the very first cells that respond to Mycobacterium tuberculosis (Mtb), the bacteria causing TB.

7 Oct 2024

Innovative immunotherapy harnesses natural killer T cells to combat solid tumors

In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.

7 Oct 2024

Antigenic mapping sheds light on SARS-CoV-2 immunity differences

A person's immune response to variants of SARS-CoV-2, the virus that causes COVID-19, depends on their previous exposure - and differences in the focus of immune responses will help scientists understand how to optimise vaccines in the future to provide broad protection.

7 Oct 2024