Protein C News and Research

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Scientists propose innovative method to test the effectiveness of coronavirus medicines

South Ural State University scientists have proposed an innovative method for testing the effectiveness of medicines for coronavirus. According to the researchers, it is necessary to focus on the maximum coincidence of the ligand and the receptor. The results of the work have been published in the highly-rated journal "Molecules"(Q1).

18 Aug 2021

Fetal membranes can heal after injury, study shows

Scientists from Queen Mary University of London and UCL have shown that fetal membranes are able to heal after injury in a new study.

18 Aug 2021

A spike-derived epitope YLQ induces robust polyfunctional cytotoxic T cell responses in COVID-19 recovered individuals

The findings reveal that the dominant spike-derived epitope induces polyfunctional CD8+ T cell response in coronavirus disease 2019 (COVID-19) recovered individuals. The study is currently available on the bioRxiv* preprint server.

18 Aug 2021

Increased chemosensory dysfunction with D614G mutation of SARS-CoV-2

A study, available on the pre-print server medRxiv, has determined the underlying molecular mechanisms of how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially the G614 strain, leads to olfactory dysfunction causing anosmia.

18 Aug 2021

Specificity of serological assays against SARS-CoV-2 in patients with parasitic infections

A new study available on the pre-print server medRxiv* aims to assess the specificity of the serological assays of SARS-CoV-2 antibodies among patients known to have a tissue-borne parasitic infection or those who reside in areas where the virus is endemic.

18 Aug 2021

Designing antimalarials with multiple targeting mechanisms of action

Malaria remains a serious global health threat. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance.

18 Aug 2021

P681R spike mutation enhances replication efficiency of SARS-CoV-2 delta variant

A team of scientists from the University of Texas, USA, has recently revealed that the P681R spike mutation is responsible for increased infectivity of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The P681R spike mutation increases the replication of the delta variant by increasing the dissociation of S1 and S2 subunits at the furin cleavage site. The study is currently available on the bioRxiv* preprint server.

18 Aug 2021

Naive B cells could be useful for predicting vaccination response in immunocompromised

A recent study conducted at the Medical University of Graz, Austria, has revealed that the number of naïve B cells in the blood could independently predict the magnitude of immune response induced by coronavirus disease 2019 (COVID-19) vaccines in immunocompromised patients. The study is currently available on the medRxiv* preprint server.

17 Aug 2021

Researchers receive $26.5 million NIH grant to pursue a new strategy for curing HIV

Over the last 40 years, HIV has shifted from a deadly and mysterious virus to one that can be controlled with daily drugs. But attempts to completely eliminate the virus from the bodies of people living with HIV, curing them for good, have failed.

17 Aug 2021

Blue light can activate key signaling pathway that plays role in embryonic development and cancer

Blue light is illuminating new understanding of a key signaling pathway in embryo development, tissue maintenance and cancer genesis.

17 Aug 2021

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Researchers at the Children's Hospital Colorado Breathing Institute, the largest pediatric cystic fibrosis (CF) clinical care center in the U.S., participated in the pivotal international multi-center Phase 3 clinical trial, sponsored by Vertex Pharmaceuticals Incorporated, leading to FDA approval of TRIKAFTA (elexacaftor/tezacaftor/ivacaftor), a highly effective CF treatment, for patients ages 6 through 11 who have at least one copy of the F508del mutation.

17 Aug 2021

Protein implicated in tumor growth may protect against neurodegenerative diseases

Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease.

17 Aug 2021

Making the nanobody big again for Cryo-EM

Researchers describe the method that allows high-resolution structure determination of small proteins by single-particle cryo-EM using a Legobody.

17 Aug 2021

Data reinforces SAB-185’s potential to neutralize SARS-CoV-2 variants

A study, available on the pre-print server bioRxiv*, evaluated the neutralizing capacity of a fully human polyclonal antibody (SAB-185) against the Delta, Kappa, and Lambda variants using a lentiviral-based pseudovirus assay.

17 Aug 2021

How delta and kappa variants of SARS-CoV-2 evade the immune system

A new study, available on the bioRxiv* preprint server, describes the neutralizing ability of the monoclonal antibodies against the variants and the difference of the ACE2 binding affinity found in the variants.

17 Aug 2021

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Now, a new study posted to the bioRxiv* preprint server focuses on functional immune memory to SARS-CoV-2, up to nine months in a Southeast Asian cohort, in the absence of re-infection.

16 Aug 2021

Vaccinating previously infected induces more potent antibodies less susceptible to escape from SARS-CoV-2 variants

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, which has claimed more than 4.3 million lives worldwide. Even after implementing various measures, such as vaccination and social restrictions, SARS-CoV-2 and its variants of concern (VoC) leave the world's public health systems and economies in turmoil.

16 Aug 2021

Tool for defining new SARS-CoV-2 spike nucleotide sequences to Pango lineage sets

In a recent study, a group of researchers determined the degree to which Pango lineages are distinguishable using spike-only nucleotide sequences.

16 Aug 2021

Analysis of landmark vitamin C study challenges the WHO's recommended daily amounts

It was wartime and food was scarce. Leaders of England's effort to wage war and help the public survive during World War II needed to know: Were the rations in lifeboats adequate for survival at sea? And, among several experiments important for public as well as military heath, how much vitamin C did a person need to avoid the deadly disease scurvy?

16 Aug 2021

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

A new study has shown that treating type 1 diabetes-prone mice with the small protein MOTS-c prevented the immune system from destroying insulin-producing pancreatic cells, effectively preventing the onset of the autoimmune disease.

16 Aug 2021

Protein C News and Research

Scientists propose innovative method to test the effectiveness of coronavirus medicines

Fetal membranes can heal after injury, study shows

A spike-derived epitope YLQ induces robust polyfunctional cytotoxic T cell responses in COVID-19 recovered individuals

Increased chemosensory dysfunction with D614G mutation of SARS-CoV-2

Specificity of serological assays against SARS-CoV-2 in patients with parasitic infections

Designing antimalarials with multiple targeting mechanisms of action

P681R spike mutation enhances replication efficiency of SARS-CoV-2 delta variant

Naive B cells could be useful for predicting vaccination response in immunocompromised

Researchers receive $26.5 million NIH grant to pursue a new strategy for curing HIV

Blue light can activate key signaling pathway that plays role in embryonic development and cancer

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Protein implicated in tumor growth may protect against neurodegenerative diseases

Making the nanobody big again for Cryo-EM

Data reinforces SAB-185’s potential to neutralize SARS-CoV-2 variants

How delta and kappa variants of SARS-CoV-2 evade the immune system

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Vaccinating previously infected induces more potent antibodies less susceptible to escape from SARS-CoV-2 variants

Tool for defining new SARS-CoV-2 spike nucleotide sequences to Pango lineage sets

Analysis of landmark vitamin C study challenges the WHO's recommended daily amounts

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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