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Gut microbiome dynamics reveal key factors influencing Enterobacteriaceae colonization

Analysis of gut microbiomes reveals co-colonization patterns and potential therapeutic targets against Enterobacteriaceae, addressing global health challenges.

14 Jan 2025

Long reads can revolutionize genetic diagnosis of rare diseases

The cause of rare diseases is increasingly being detected through genome sequencing, which involves reading the entire human DNA by first breaking it into small pieces-short reads.

13 Jan 2025

Scientists discover why cancer cells die differently after radiotherapy

Scientists at Children's Medical Research Institute have solved a big mystery in cancer research – why cells die in different ways following radiotherapy.

13 Jan 2025

New test could predict lung cancer outcomes using tumor DNA

Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to detect circulating tumor DNA can predict lung cancer outcome in a Cancer Research UK-funded study.

13 Jan 2025

Short-chain fatty acids propionate and butyrate directly modify chromatin to regulate gene expression

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer and normal cellular processes.

13 Jan 2025

World’s largest proteomics study launched by UK Biobank

UK Biobank has today announced the launch of the world's most comprehensive study of the proteins circulating in our bodies, which will transform the study of diseases and their treatments.

9 Jan 2025

New test predicts lung cancer survival better than current standards

Researchers at the Francis Crick Institute, the UCL Cancer Institute and UCLH have shown that a test called ORACLE can predict lung cancer survival at the point of diagnosis better than currently used clinical risk factors.

9 Jan 2025

Unraveling the molecular mechanisms of disease-causing mutations

Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the journal Nature. Unstable proteins are more likely to misfold and degrade, causing them to stop working or accumulate in harmful amounts inside cells.

9 Jan 2025

Stanford researchers develop AI model to enhance cancer prognosis predictions

The melding of visual information (microscopic and X-ray images, CT and MRI scans, for example) with text (exam notes, communications between physicians of varying specialties) is a key component of cancer care.

8 Jan 2025

New AI method predicts gene activity in human cells

Using a new artificial intelligence method, researchers at Columbia University Vagelos College of Physicians and Surgeons can accurately predict the activity of genes within any human cell, essentially revealing the cell's inner mechanisms.

8 Jan 2025

Mutation in ASXL1 gene triggers chain reaction leading to blood disorders

Scientists at La Jolla Institute for Immunology (LJI) have discovered how a mutated gene kicks off a dangerous chain of events during blood cell production.

8 Jan 2025

UCD researchers discover gene mutation linked to vision problems in zebrafish

Researchers in University College Dublin (UCD) have discovered that a mutation in a gene called emc1 causes major vision problems in zebrafish.

8 Jan 2025

AI-based method predicts progression of autoimmune diseases

Autoimmune diseases, where the immune system mistakenly attacks the body's own healthy cells and tissues, often have a preclinical stage before diagnosis that's characterized by mild symptoms or certain antibodies in the blood.

7 Jan 2025

Study finds microRNA target to combat breast cancer treatment resistance

A new University of Cincinnati Cancer Center study has identified a particular strand of microRNA as a promising new target for overcoming breast cancer treatment resistance and improving outcomes.

7 Jan 2025

Does smoking increase chronic kidney disease risk?

Researchers determine whether smoking increases the risk of chronic kidney disease.

7 Jan 2025

How loneliness and social isolation impact your health at the molecular level

This research identifies proteins linking social relationships to cardiovascular disease and mortality, offering insights for disease prediction and prevention.

7 Jan 2025

Decades of research push cytomegalovirus vaccine closer to reality

Researchers review decades of progress in human cytomegalovirus (HCMV) vaccine development, emphasizing challenges, innovative platforms, and the critical need for effective prevention strategies.

6 Jan 2025

AI-based SCORPIO tool offers better cancer immunotherapy predictions

Doctors around the world may soon have access to a new tool that could better predict whether individual cancer patients will benefit from immune checkpoint inhibitors - a type of immunotherapy - using only routine blood tests and clinical data.

6 Jan 2025

Y chromosome’s unexpected impact on aging and disease in men

Loss of the Y chromosome (LOY) in men, a dynamic mutation linked to aging, impairs immune function and increases risks of cancer, Alzheimer’s, and cardiovascular diseases, making it a promising biomarker and therapeutic target.

5 Jan 2025

Bacteria in Lake Mendota evolve in cycles following seasonal shifts

Like Bill Murray in the movie "Groundhog Day," bacteria species in a Wisconsin lake are in a kind of endless loop that they can't seem to shake. Except in this case, it's more like Groundhog Year.

3 Jan 2025