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Study: aPKC inhibitors may provide new therapeutic option for blinding eye diseases

Many eye diseases, including diabetic retinopathy and macular degeneration, exhibit increased permeability of blood vessels in the macular (central) portion of the retina leading to abnormal fluid accumulation and vision loss.

14 Sep 2018

Endocrine Society announces winners of prestigious 2019 Laureate Awards

The Endocrine Society today announced it has chosen 13 leading endocrinologists as winners of its prestigious 2019 Laureate Awards, the top honors in the field.

6 Sep 2018

Lymph node structural cells exert control over T cell responses

Until now, the study of the immune system has focused almost exclusively on white blood cells, and T cells in particular, as the body’s major infection fighters.

6 Sep 2018

Researchers find how NF2 gene mutations lead to out-of-control cellular proliferation

A team of Massachusetts General Hospital Cancer Center researchers has determined one way that mutations in a gene involved in a rare, hereditary cancer syndrome lead to out-of-control cellular proliferation.

29 Aug 2018

Scientists reveal how immune system strives to protect the lungs of infants with flu

The immune system appears to put a premium on maintaining lung function in infants infected with the influenza virus by mounting a rapid response to repair damaged cells, according to research led by St. Jude Children’s Research Hospital. The findings appear today in the scientific journal Immunity.

29 Aug 2018

Research solves mystery on nature of EGFR signaling and how it drives development

What do cancer and the growing legs of a fruit fly have in common? They can both be influenced by a single molecule, a protein that tends to call the shots inside of embryos as they develop into living, breathing animals.

28 Aug 2018

Additional inhibitor could be key to helping anti-VEGF therapies overcome resistance in glioblastoma

Adding another inhibitor to therapies that cut off a tumor's access to blood vessels could be the key to helping those therapies overcome resistance in glioblastoma, a deadly form of brain cancer.

27 Aug 2018

'Plastic antibodies' effectively target and eliminate tumor cells

A joint research team from Russia and the U.K. has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs, or "plastic antibodies." NanoMIPs are synthetic polymers that can function as antibodies, selectively binding to target proteins on the surface of cancer cells.

23 Aug 2018

Scientists design biomaterial that stimulates growth of blood vessels in teeth after root canal

A root canal ranks high on most people's list of dreaded dental procedures. Although the lengthy and sometimes painful surgery relieves the agony of an infection, a root canal results in a dead tooth with no living soft tissue, or dental pulp, inside.

22 Aug 2018

Researchers identify genes responsible for inherited breast cancer in Nigerian women

For the first time, DNA contributed by Sub-Saharan African women has been thoroughly evaluated with innovative genomics technology in an effort to understand the genetic bases for breast cancer in African populations.

22 Aug 2018

Study unravels cellular and molecular mechanisms behind dermal condensate formation

Hair growth is regulated by a small cluster of hair-specific fibroblasts, the dermal papilla. But exactly how dermal papilla forms has remained elusive until now.

20 Aug 2018

Immune cell found to play important role in photosensitivity

Researchers at Hospital for Special Surgery have discovered that a type of immune cell known as Langerhans appears to play an important role in photosensitivity, an immune system reaction to sunlight that can trigger severe skin rashes.

16 Aug 2018

UIC researchers receive NIH funding to develop a better way to regenerate bone or tissues

University of Illinois at Chicago researchers have received approximately $2 million in funding from the National Institutes of Health to develop a better way to regenerate bone or tissues that have been lost to disease or injury.

14 Aug 2018

Scientists discover key vulnerability of mixed lineage leukemia

Childhood leukemia is a diagnosis that no family ever wants to endure. While the treatment of most types of leukemia has improved steadily over the years, a few specific types remain very difficult to treat.

13 Aug 2018

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

A biochemistry instructor curious about an enzyme discovered in the damaged neurons of people with multiple sclerosis made a leap toward a potential cure for countless neurodegenerative ills.

7 Aug 2018

Researchers uncover new mechanisms underlying common kidney cancer in children

Connecting two previously unrelated insights about the formation of pediatric kidney cancer, researchers at UT Southwestern Medical Center have uncovered the means by which the cancer continues to grow, providing potential targets for more effective treatments in the future.

2 Aug 2018

European Commission approves Pfizer’s first oncology biosimilar

Pfizer Inc. today announced the European Commission has approved TRAZIMERA, a biosimilar to Herceptin (trastuzumab), for the treatment of human epidermal growth factor overexpressing breast cancer and HER2 overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma.

31 Jul 2018