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Newly developed bioluminescence sensors pave way for drug discovery

Canadian researchers, working in partnership with Brazilian colleagues, have developed 13 bioluminescence sensors for use in testing the effectiveness of new medical drugs in the laboratory.

2 Mar 2019

Researchers discover origin of resistance to lung cancer

For treating cancer, drugs based on molecules known as tyrosine kinase inhibitors are sometimes used. One such tyrosine kinase inhibitor, called osimertinib, has been used to treat EGFR-mutated lung cancer with a certain degree of efficacy.

25 Feb 2019

Researchers engineer 'antibody-like' T cell receptors to combat deadly virus

Researchers have engineered "antibody-like" T cell receptors that can specifically stick to cells infected with cytomegalovirus, or CMV, a virus that causes lifelong infection in more than half of all adults by age 40.

23 Feb 2019

Novel MRI sensor can peer deep into the brain to detect intracellular calcium activity

Calcium is a critical signaling molecule for most cells, and it is especially important in neurons. Imaging calcium in brain cells can reveal how neurons communicate with each other; however, current imaging techniques can only penetrate a few millimeters into the brain.

22 Feb 2019

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

An increase in the incidence and mortality rate of cancer has been noted worldwide, especially for lung cancer.

22 Feb 2019

Novel ratiometric fluorescent probe for studying cellular activity of anticancer drug

NUS chemists have developed a novel ratiometric fluorescent probe for studying cellular activity of the clinically important anticancer drug cisplatin for next generation drug development.

21 Feb 2019

Intense exercise, fasting and hormones can enhance waste-protein removal, study shows

The body's ability to adapt to changing conditions and shifting physiologic demands is essential to survival. To do so, each cell must be able to dispose of damaged or unnecessary proteins--a quality-control mechanism critical for cellular performance and for the health of the entire organism.

21 Feb 2019

New intracellular delivery system using gold nano-stars

Researchers from Russian Academy of Sciences developed a new method for star-shaped nanoparticles synthesis based on laser irradiation.

21 Feb 2019

New, versatile technique for remote control of transplanted cells in Parkinson's

Neurodegenerative conditions such as Parkinson’s disease are a major public health issue, especially given the ageing population in Europe and beyond. Parkinson’s now affects more than 1 900 people per 100 000 among those aged 80 and older.

20 Feb 2019

Customizing the Cellular Microenvironment to Improve Physiological Relevance

An interview with Marie-Charlotte Manus, discussing a new technology called PRIMO that improves the physiological relevance of cells in culture.

From Alveole 18 Feb 2019

Moffitt researchers shed light on how CAR T cells function mechanistically

The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient's own immune system to target cancer cells.

15 Feb 2019

New research explains presence of ‘natural’ magnetism in human cells

Although magnetic nanoparticles are being used more and more in cell imaging and tissue bioengineering, what happens to them within stem cells in the long term remained undocumented.

13 Feb 2019

Human brain protein linked with autism has an effect on fruit fly behavior

A mutant gene that encodes a brain protein in a child with autism has been placed into the brains of fruit flies. Fruit flies hosting that gene produce the variant human brain protein and show abnormal behaviors of fear, repetitive activity and altered social interaction, reminiscent of autism impairments.

12 Feb 2019

Novel protein sensor allows researchers to observe nicotine's movements in cells

When a person takes a puff on a cigarette, nicotine floods into the brain, latching onto receptors on the surface of neurons and producing feelings of happiness. But nicotine does not simply stay on the surface of cells--the drug actually permeates into neural cells and alters them from the inside out.

8 Feb 2019

New simulations offer insights on vital atomic-scale drug-cardiac cells interactions

To unravel the mysterious mechanisms of drug potency for the treatment of cardiac arrhythmias, a group of researchers at UC Davis have developed novel simulations that provide insights on vital atomic-scale drug-cardiac cells interactions.

8 Feb 2019

Research opens up new therapeutic area to better manage chronic inflammatory diseases

Atherosclerosis is a disease defined by the accumulation of fatty deposits called plaques inside the arteries. It is a leading cause of heart attacks and strokes.

4 Feb 2019

Researchers unravel path of metallodrug in a breast cancer cell

Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic molecule as an antitumor drug.

4 Feb 2019

Discovery of proteins that control mucin secretion reveals clues to treating colon, airway diseases

Cells produce mucins at a constant rate, and when exposed to an allergen or pathogen, they produce more mucin in a rapid burst. Both the constant and rapid mucin secretion is controlled by calcium.

1 Feb 2019

Study opens new avenue for treating ulcerative colitis or Crohn's disease

An international study led by the Complutense University of Madrid (UCM) and the National Centre for Cardiovascular Research (CNIC) has found that Lactobacillus bacteria present in the intestinal microbiota interact with immune system cells to strengthen the intestinal barrier.

31 Jan 2019

Researchers identify new therapeutic targets for kidney fibrosis

Chronic kidney disease is a global health concern, affecting about 10 percent of the world's population--and increasing in prevalence. A final, common pathway in chronic kidney disease is fibrosis.

29 Jan 2019

Intracellular News and Research

Newly developed bioluminescence sensors pave way for drug discovery

Researchers discover origin of resistance to lung cancer

Researchers engineer 'antibody-like' T cell receptors to combat deadly virus

Novel MRI sensor can peer deep into the brain to detect intracellular calcium activity

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

Novel ratiometric fluorescent probe for studying cellular activity of anticancer drug

Intense exercise, fasting and hormones can enhance waste-protein removal, study shows

New intracellular delivery system using gold nano-stars

New, versatile technique for remote control of transplanted cells in Parkinson's

Customizing the Cellular Microenvironment to Improve Physiological Relevance

Moffitt researchers shed light on how CAR T cells function mechanistically

New research explains presence of ‘natural’ magnetism in human cells

Human brain protein linked with autism has an effect on fruit fly behavior

Novel protein sensor allows researchers to observe nicotine's movements in cells

New simulations offer insights on vital atomic-scale drug-cardiac cells interactions

Research opens up new therapeutic area to better manage chronic inflammatory diseases

Researchers unravel path of metallodrug in a breast cancer cell

Discovery of proteins that control mucin secretion reveals clues to treating colon, airway diseases

Study opens new avenue for treating ulcerative colitis or Crohn's disease

Researchers identify new therapeutic targets for kidney fibrosis

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