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Prime editing enables more precise correction of genetic problems than traditional CRISPR

The latest gene editing technology, prime editing, expands the "genetic toolbox" for more precisely creating disease models and correcting genetic problems, scientists say.

30 Mar 2021

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

A study conducted at the University of Campinas in the state of São Paulo, Brazil, shows that compounds produced by gut microbiota (bacteria and other microorganisms) during fermentation of insoluble fiber from dietary plant matter do not affect the ability of the novel coronavirus SARS-CoV-2 to enter and replicate in cells lining the intestines.

30 Mar 2021

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells.

30 Mar 2021

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care.

30 Mar 2021

Adverse childhood experiences linked to adolescents' delinquent behaviors

About 61% of Americans have had at least one Adverse Childhood Experience (ACE), experts' formal term for a traumatic childhood event.

30 Mar 2021

Determination of vaccine-elicited SARS-CoV-2 antibodies in breastmilk

A new study has analyzed the levels of SARS-CoV-2 antibodies elicited by the novel COVID-19 vaccines in breastmilk.

30 Mar 2021

Strengths-based approach may attribute to positive outcomes in children with autism spectrum disorder

One of the biggest longitudinal research studies of its kind in the world led by The Hospital for Sick Children (SickKids) and the Centre for Addiction and Mental Health (CAMH) suggests that positive outcomes for children with autism spectrum disorder (ASD) are more common than previously thought.

30 Mar 2021

Gestational exposure to environmental toxicants linked to autistic-like behaviors in children

A new study by Simon Fraser University's Faculty of Health Sciences researchers - published today in the American Journal of Epidemiology - found correlations between increased expressions of autistic-like behaviors in pre-school aged children to gestational exposure to select environmental toxicants, including metals, pesticides, polychlorinated biphenyls (PCBs), phthalates, and bisphenol-A (BPA).

30 Mar 2021

Study shows how innate valence is encoded

Since the beginning of the pandemic, a loss of smell has emerged as one of the telltale signs of COVID-19. Though most people regain their sense of smell within a matter of weeks, others can find that familiar odors become distorted.

30 Mar 2021

New study reports increased spread of B.1.1.7 variant in Houston, Texas

Research led by Jimmy Gollihar from the CCDC Army Research Laboratory-South in Austin, Texas found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.7 —first detected last fall in England — increased in Houston, Texas. The B.1.1.7 variant is rapidly spreading with a case doubling time of 6.9 days.

29 Mar 2021

Parents report lower rates of child car seat use in ride-share

A national survey of parents revealed that most parents who used ride-share services did so with their children, but only half of the respondents reported that children who were 8 years or younger traveled in the recommended child car seats or booster seats when in ride-share vehicles.

29 Mar 2021

Apes mount a much stronger early immune response compared to African and Asian monkeys

A new study out of the University of Chicago and the University of Illinois Urbana-Champaign in humans, chimpanzees, rhesus macaques and baboons has found key differences in early gene expression in response to pathogen exposure, highlighting the importance of choosing the right animal model for the right questions.

29 Mar 2021

Restricting excessive consumption of added sugars may reduce NAFLD risk in children

A review of more than 20 studies by researchers at Arizona State University and the Translational Genomics Research Institute, an affiliate of City of Hope, suggests that nonalcoholic fatty-liver disease (NAFLD) is a growing dietary problem for children across the globe.

29 Mar 2021

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

A team of researchers led by UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital (GOSH) has found that metformin - a drug commonly used to treat Type 2 diabetes - can successfully reduce symptoms associated with tuberous sclerosis complex (TSC), including reduction in the frequency of seizures and the size of brain tumors.

29 Mar 2021

How has the COVID-19 pandemic impacted birth statistics in the U.S.?

A new study examines national-level changes in fertility, preterm birth and other obstetric outcomes, in the U.S., over the period of the pandemic throughout 2020.

29 Mar 2021

It’s not just QAnon. Democrats and independents also want to recall California’s governor.

California Gov. Gavin Newsom is framing the burgeoning effort to remove him from office as a fringe Republican movement backed by right-wing extremists, Trump supporters and QAnon conspiracy theorists.

29 Mar 2021

New study provides the most comprehensive reviews of advancements in contact lenses

A newly-published paper represents one of the most comprehensive reviews of advancements to come in contact lenses, catapulting the commonly-used medical device to applications well beyond refractive error correction.

29 Mar 2021

Large U.S. study identifies sociodemographic and clinical factors associated with SARS-CoV-2 testing and positivity

The massive and continuing outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), throughout the world, has led to a staggering toll of over 549,000 deaths in the USA, among over 30 million cases. A new preprint research paper posted to the medRxiv* server discusses the factors related to the chances of testing positive for this virus.

29 Mar 2021

Mimicking stress signals can protect the brain and retina from aging

How do different parts of the body communicate? Scientists at St. Jude are studying how signals sent from skeletal muscle affect the brain.

27 Mar 2021

Latino Californians are among hardest hit by COVID-19

The COVID-19 surge of summer through winter 2020‒2021 devastated all population groups. Yet when the death rates of Latinos are compared to non-Hispanic white (NHW) rates in every age group, there is a significant disparity between the two: Latino death rates are from two to seven times higher than NHW rates.

26 Mar 2021

Children News and Research

Prime editing enables more precise correction of genetic problems than traditional CRISPR

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

Adverse childhood experiences linked to adolescents' delinquent behaviors

Determination of vaccine-elicited SARS-CoV-2 antibodies in breastmilk

Strengths-based approach may attribute to positive outcomes in children with autism spectrum disorder

Gestational exposure to environmental toxicants linked to autistic-like behaviors in children

Study shows how innate valence is encoded

New study reports increased spread of B.1.1.7 variant in Houston, Texas

Parents report lower rates of child car seat use in ride-share

Apes mount a much stronger early immune response compared to African and Asian monkeys

Restricting excessive consumption of added sugars may reduce NAFLD risk in children

Type 2 diabetes drug can successfully reduce symptoms associated with tuberous sclerosis complex

How has the COVID-19 pandemic impacted birth statistics in the U.S.?

It’s not just QAnon. Democrats and independents also want to recall California’s governor.

New study provides the most comprehensive reviews of advancements in contact lenses

Large U.S. study identifies sociodemographic and clinical factors associated with SARS-CoV-2 testing and positivity

Mimicking stress signals can protect the brain and retina from aging

Latino Californians are among hardest hit by COVID-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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