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Genetic mutation in esophageal cancer found to have dual effects

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer.

3 Jan 2025

Study identifies novel IgAN loci through pleiotropy

IgA nephropathy (IgAN) is a prevalent form of primary glomerulonephritis characterized by the deposition of IgA in the glomerular mesangium, leading to a spectrum of histopathological lesions and a variable clinical course that can progress to end-stage renal disease in a significant proportion of patients.

2 Jan 2025

New nanopore-based tool enables single molecule disease detection

UC Riverside scientists have developed a nanopore-based tool that could help diagnose illnesses much faster and with greater precision than current tests allow, by capturing signals from individual molecules.

2 Jan 2025

Study provides new insights into the genetic underpinnings of pediatric cancers

Largescale changes in the genome inherited from parents are significant risk factors for pediatric solid tumors, such as Ewing sarcoma, neuroblastoma, and osteosarcoma, according to a new study.

2 Jan 2025

Scientists launch public resource to classify cancer subtypes for better diagnosis

A multi-institutional team of scientists has developed a free, publicly accessible resource to aid in classification of patient tumor samples based on distinct molecular features identified by The Cancer Genome Atlas (TCGA) Network.

2 Jan 2025

Histone markers predict human age with accuracy comparable to DNA methylation clocks

Researchers unveil histone-based age predictors, offering a new window into epigenetic aging and its shared patterns across tissues.

2 Jan 2025

KFF Health News' 'What the Health?': Francis Collins on supporting NIH and finding common ground

This week, KFF Health News' "What the Health?" presents a conversation with Francis Collins, former National Institutes of Health director and White House science adviser.

2 Jan 2025

Study reveals how fatty liver disease leads to liver cancer

Scientists at University of California San Diego School of Medicine have shed new light on the development of liver cancer, the sixth most frequently diagnosed cancer and fourth leading cause of cancer deaths worldwide.

2 Jan 2025

AI models struggle in real-world medical conversations

Artificial intelligence tools such as ChatGPT have been touted for their promise to alleviate clinician workload by triaging patients, taking medical histories and even providing preliminary diagnoses.

2 Jan 2025

Unraveling retrotransposon mechanisms in centromere insertion

A joint research group team led by Sayuri Tsukahara and Tetsuji Kakutani of the University of Tokyo has clarified a mechanism of how retrotransposons, genetic elements that can "jump around" chromosomes and are known drivers of evolution, preferentially insert in the centromere.

1 Jan 2025

Scientists pinpoint regions and species fueling coronavirus evolution in bats

Study uncovers the evolution, transmission, and geographic spread of bat coronaviruses in China, revealing key insights into hotspots and the origins of SARS-CoV-2.

1 Jan 2025

Fruit flies steal bacterial defense to survive parasitic wasps

In the continual arms race between parasites and their hosts, innovation was thought to be the key to a successful attack or defense that one-ups the competition.

24 Dec 2024

Study unveils NAD's link to aging and disease development

UiB researchers are behind a new discovery that tells us how associated neurodegenerative diseases might develop.

23 Dec 2024

New research project aims to uncover molecular factors behind malaria’s deadliest strain

Nearly half the world's population lives in regions where malaria is endemic, with the parasite Plasmodium falciparum accounting for approximately 95% of malaria-related deaths globally.

20 Dec 2024

New insights into glioblastoma resistance to temozolomide

In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used as the front-line medicine in its treatment.

19 Dec 2024

Study uncovers a previously unknown genetic link to autism spectrum disorder

New research published in The American Journal of Human Genetics has identified a previously unknown genetic link to autism spectrum disorder (ASD). The study found that variants in the DDX53 gene contribute to ASD, providing new insights into the genetic underpinnings of the condition.

19 Dec 2024

Syphilis family traced to Pre-Columbian Americas

In spring 1495, the Italian campaign of Charles VIII of France was interrupted by an intense outbreak of an apparently unknown illness – a disease of high mortality that quickly engulfed the whole of Europe and left its survivors with life changing impairments to their bodies and minds.

18 Dec 2024