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Phase 3 study of tanezumab in patients with osteoarthritis pain meets all three co-primary endpoints

Pfizer Inc. and Eli Lilly and Company today announced that a 16-week Phase 3 study in patients with osteoarthritis pain evaluating subcutaneous administration of tanezumab, an investigational humanized monoclonal antibody, met all three co-primary endpoints.

19 Jul 2018

Gene regulator associated with protein pileup in exfoliation glaucoma

In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes.

19 Jul 2018

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

The U.S. Food and Drug Administration today approved Kisqali (ribociclib) in combination with an aromatase inhibitor for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, as initial endocrine-based therapy.

19 Jul 2018

Why men may recover more quickly from influenza infections than women

Men may recover more quickly from influenza infections because they produce more of a key lung-healing protein, a study from scientists at Johns Hopkins Bloomberg School of Public Health suggests.

17 Jul 2018

Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast cancer

Phase 1b clinical trial results published in JAMA Oncology show promise for the combination of tucatinib with T-DM1 against heavily pretreated HER2-positive breast cancer.

11 Jul 2018

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

A Ludwig Cancer Research study explains why a particular mutation in the epidermal growth factor receptor, a cell surface protein, results in more aggressive tumors and poorer overall survival of patients diagnosed with the brain cancer glioblastoma multiforme.

10 Jul 2018

Researchers use gene therapy to cure obesity and type 2 diabetes in mice

A research team from the UAB led by Professor Fatima Bosch has managed to cure obesity and type 2 diabetes in mice using gene therapy.

9 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

Researchers at The University of Kansas Cancer Center have launched a clinical trial that eliminates radiation from the treatment protocol for an invasive type of breast cancer that accounts for one-fifth of all breast cancer patients.

30 Jun 2018

Researchers discover novel function of fibroblast growth factor 2 for spermatogonial stem cell

A research team found a novel function of fibroblast growth factor 2, a self-renewal factor for spermatogonial stem cell which is the origin of the sperm production.

30 Jun 2018

Mice study opens new avenues to develop therapies for growth disorders

Maintaining equal growth rates in opposing limbs is crucial for animals to achieve a symmetrical adult form; what happens if something goes wrong with one limb during development?

27 Jun 2018

Study reveals new way to inhibit capillary leakage in sepsis

Leakage from the blood capillaries is a key mechanism leading to septic shock and multiorgan failure, which affect millions of patients annually worldwide. However, there is no effective way to inhibit the vessel leakiness. A new study by scientists at the University of Helsinki and Wihuri Research Institute demonstrates that vascular leakage can be inhibited by targeting vascular integrins.

25 Jun 2018

Researchers invent medical device for proliferation, differentiation of neural stem cells

The research team of Hong Kong Baptist University invented a medical device with a specific nanotechnology layer for the proliferation and differentiation of neural stem cells in vitro.

20 Jun 2018

Study: Effects of in vitro fertilization depend on genetic variation inherited from parents

In vitro fertilization affects the regulatory region of genes essential for placental and embryonic growth, as well as the birth weight.

19 Jun 2018

Scientists discover genetic causes underlying group of related infant cancers

The genetic causes of a group of related infant cancers have been discovered by scientists at the Wellcome Sanger Institute, the University of Wuerzburg and their collaborators.

18 Jun 2018

Vitamin D level in girls associated with muscle strength

Girls are stronger with higher levels of vitamin D, but the association was not found in boys. These are the results from a new large study from the Odense Child Cohort, recently published in the Journal of Clinical Endocrinology and Metabolism.

14 Jun 2018

Hydrogel releases nerve-protecting agent to restore breathing in animal models

One of the most severe outcomes of spinal cord injury from car accidents, sports impacts, or other neck trauma, is losing the ability to control breathing, with patients often requiring artificial ventilation for the rest of their lives.

12 Jun 2018

Experimental drug shows potential to improve bladder function after spinal cord injury

An experimental drug that blocks abnormal neural communication after spinal cord injury could one day be the key to improving quality of life by improving bladder function, new research suggests.

5 Jun 2018

Scientists uncover 'Achilles heel' in deadly form of brain cancer

Scientists at Virginia Commonwealth University believe they have uncovered an "Achilles heel" of glioblastoma multiforme, the most common and deadly form of brain cancer.

5 Jun 2018

New guideline for HER2 testing in breast cancer benefits patients and clinicians

Published today, a Focused Update to the American Society of Clinical Oncology/College of American Pathologists guideline for human epidermal growth factor receptor 2 (HER2) testing in breast cancer brings new levels of clarity that will benefit patients and clinical teams alike.

31 May 2018

Growth Factor News and Research

Phase 3 study of tanezumab in patients with osteoarthritis pain meets all three co-primary endpoints

Gene regulator associated with protein pileup in exfoliation glaucoma

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

Why men may recover more quickly from influenza infections than women

Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast cancer

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

Researchers use gene therapy to cure obesity and type 2 diabetes in mice

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

Researchers discover novel function of fibroblast growth factor 2 for spermatogonial stem cell

Mice study opens new avenues to develop therapies for growth disorders

Study reveals new way to inhibit capillary leakage in sepsis

Researchers invent medical device for proliferation, differentiation of neural stem cells

Study: Effects of in vitro fertilization depend on genetic variation inherited from parents

Scientists discover genetic causes underlying group of related infant cancers

Vitamin D level in girls associated with muscle strength

Hydrogel releases nerve-protecting agent to restore breathing in animal models

Experimental drug shows potential to improve bladder function after spinal cord injury

Scientists uncover 'Achilles heel' in deadly form of brain cancer

New guideline for HER2 testing in breast cancer benefits patients and clinicians

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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