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Tocilizumab fails to affect COVID-19 disease outcomes in Boston trial

Researchers from the various Massachusetts hospitals performed the Boston Area COVID-19 Consortium (BACC) Bay Tocilizumab Trial using tocilizumab administered early in the disease course to determine if early IL-6 receptor blockade limits progression of COVID-19 to hypoxemic respiratory failure or death. Their work is published in the prestigious New England Journal of Medicine.

25 Oct 2020

Moffitt researchers find immune-oncologic differences in prostate tumors of African American men

Prostate cancer is the most common type of cancer among American men after skin cancer, but the disease does not affect all races equally.

21 Oct 2020

New smart surface pulls critical COVID-19 marker from the blood

When COVID-19 attacks, the immune system produces a cytokine, or protein, called Interleukin-6 (IL-6), whose concentrations can offer vital information about a patient's level and stage of infection.

20 Oct 2020

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Since the beginning of the COVID-19 pandemic, researchers have noted that women are generally less severely affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to the exploration into estrogen and androgens' role in the hyperinflammatory clinical phenotypes of COVID-19. A recent study published on the preprint server bioRxiv shows that drugs targeting androgens and TMPRSS2 inhibitors may potentially combat the pandemic.

20 Oct 2020

Scientists discover key enzyme involved in the development of autoimmune diseases

Scientists affiliated with the Center for Research on Inflammatory Diseases (CRID http://crid.fmrp.usp.br), hosted by the University of São Paulo (USP) in Brazil, have discovered that an enzyme involved in key metabolic processes also plays a role in immune cell differentiation and hence in the development of autoimmune diseases.

19 Oct 2020

Scientists receive £265,000 to investigate link between vascular dementia and heart disease

Scientists from the University of Sheffield and University of Manchester have been awarded £265,000 from the British Heart Foundation, to investigate the links between vascular dementia and heart disease, and test whether a drug currently used to treat arthritis could also be used as a treatment for vascular dementia.

16 Oct 2020

Certain live-attenuated vaccines can prevent severe complications of COVID-19

COVID-19 continues to wreak havoc globally, with over one million deaths to date. Yet what if an existing vaccine could make COVID-19 less deadly? A study just published put the theory to test, with promising results.

15 Oct 2020

Anti-inflammatory drugs may hold the potential to alleviate Parkinson's disease, study suggests

Around 15% of Parkinson's disease cases are related to a known genetic background, out of which mutations in the Parkin and PINK1 genes are among the most frequent ones.

14 Oct 2020

Characterization of prognostic markers to predict COVID-19 severity

A team of scientists from the United Kingdom has revealed that markers of endothelial cell injury are associated with severe and fatal outcome of coronavirus disease 2019 (COVID-19). The study is currently available on the medRxiv* preprint server.

14 Oct 2020

STAT3 deficiency reduces emotional reactivity, shows study

Numerous scientific studies indicate that inflammatory processes play a key role in the development of psychiatric disorders.

14 Oct 2020

New blood test can accurately predict severe form of Infection in Covid-19 Patients

Scientists have developed, for the first time, a score that can accurately predict which patients will develop a severe form of Covid-19.

14 Oct 2020

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

Natural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have been developed into a novel form of immunotherapy to treat patients with cancer.

13 Oct 2020

New therapy may help treat or prevent multiple sclerosis

Multiple sclerosis, an autoimmune disease of the central nervous system that affects millions worldwide, can cause debilitating symptoms for those who suffer from it.

13 Oct 2020

Higher HMBGB1 levels associated with obesity, inflammation, and cardiovascular disease in younger black adults

A "danger molecule" is higher in the blood of younger black adults than whites, females than males and increases with weight and age, researchers report in the first large, longitudinal study associating circulating HMGB1 levels with obesity, inflammation promoters and early indicators of cardiovascular risk in humans.

9 Oct 2020

Novel feed ingredient can reduce effects of coccidiosis in broiler chickens

Broiler chicken producers the world over are all too familiar with coccidiosis, a parasite-borne intestinal disease that stalls growth and winnows flocks.

8 Oct 2020

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system.

6 Oct 2020

Study confirms SARS-CoV-2 spike glycoprotein promotes a hyper-inflammatory immune response

A group of researchers from Australia and China recently demonstrated how SARS-CoV-2 spike glycoprotein subunit 1 can induce a pro-inflammatory signaling pathway (leading to cytokines deployment and epithelial damage in human bronchial epithelial cells), but also highlighted the potential of peptide-based antivirals in tackling this novel coronavirus.

5 Oct 2020

Interleukin 2 News and Research

Tocilizumab fails to affect COVID-19 disease outcomes in Boston trial

Moffitt researchers find immune-oncologic differences in prostate tumors of African American men

New smart surface pulls critical COVID-19 marker from the blood

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Scientists discover key enzyme involved in the development of autoimmune diseases

Scientists receive £265,000 to investigate link between vascular dementia and heart disease

Certain live-attenuated vaccines can prevent severe complications of COVID-19

Anti-inflammatory drugs may hold the potential to alleviate Parkinson's disease, study suggests

Characterization of prognostic markers to predict COVID-19 severity

STAT3 deficiency reduces emotional reactivity, shows study

New blood test can accurately predict severe form of Infection in Covid-19 Patients

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

New therapy may help treat or prevent multiple sclerosis

Higher HMBGB1 levels associated with obesity, inflammation, and cardiovascular disease in younger black adults

Novel feed ingredient can reduce effects of coccidiosis in broiler chickens

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Study confirms SARS-CoV-2 spike glycoprotein promotes a hyper-inflammatory immune response

Lung tissue in fatal COVID-19 shows broad cell tropism and extensive damage

Wearable device tracks biomarkers in sweat associated with inflammatory bowel disease

Auto-antibodies may explain why some people develop severe COVID-19

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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