Efficacy News and Research

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LVIS stent-assisted coiling effectively treats wide-necked intracranial aneurysms

Intracranial aneurysms are weakened, bulging areas of cerebral arteries that can rupture, causing subarachnoid hemorrhage and, in turn, significant disability or death.

11 Aug 2026

Comprehensive BMJ review identifies most effective bipolar disorder treatments

The most comprehensive review to date has identified the most effective bipolar disorder treatments across different age groups and mood phases. It was published today in The BMJ.

11 Aug 2026

Bright-light therapy may reduce attention lapses during night work

Light therapy may improve alertness and attention/reaction time during simulated night shifts, with the strongest benefits appearing after light exposure. Effects on executive function were smaller and largely limited to treatment, while substantial study heterogeneity and limited real-world evidence warrant caution.

11 Aug 2026

Single-dose psilocybin shows promise for treatment-resistant depression in NHS trial

A single 25-mg dose of psilocybin with psychological support was feasible to deliver within an NHS setting and produced large preliminary reductions in depressive symptoms among adults with treatment-resistant depression. The Phase 2 feasibility trial also found the treatment was generally well tolerated, although functional unblinding and expectancy effects mean larger, longer efficacy studies are needed.

10 Aug 2026

New drug delivers promising survival gains in pancreatic cancer

About 90% of people with pancreatic cancer have pancreatic ductal adenocarcinoma (PDAC), which is driven by an activating mutation in the KRAS gene.

9 Aug 2026

Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma

The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent key drivers of hepatocellular carcinoma (HCC) progression. mTOR-mediated ferroptosis suppression has been implicated in HCC resistance to chemotherapy.

7 Aug 2026

Plant-based nanoemulsion offers greener approach to pest control

In an effort to develop more environmentally friendly alternatives to synthetic insecticides, researchers from Kyushu University have developed and tested a new insecticide made from compounds derived from garlic and spearmint.

7 Aug 2026

Researchers find a new genetic vulnerability in acute myeloid leukemia

A study published in Nature Cell Biology reports a new vulnerability in acute myeloid leukemia (AML) that might lead to novel therapies to treat this cancer while minimizing harm to normal cells.

7 Aug 2026

Scientists map key differences in stem cell potency for treating knee osteoarthritis

Knee osteoarthritis (KOA) affects more than 1 in 10 people over 40 years of age, impairing patients' mobility and quality of life.

7 Aug 2026

Genetic analysis of 1 million people points to FNIP1 as a promising metabolic target

Mega-scale exome sequencing of 1,032,116 people identified 59 independent genes linked to the TG:HDL ratio, including 44 rare-coding associations not detected in the previous largest analysis. Ultra-rare FNIP1 loss-of-function variants were associated with favorable fat distribution, lower liver fat and glycemia, and around 60% lower odds of a composite cardiometabolic disease outcome.

7 Aug 2026

D-serine promotes gastric cancer growth by suppressing tumor immunity

Researchers from Keio University have found that D-serine increases the growth of gastric cancer by creating an immunosuppressive and anti-inflammatory tumor microenvironment.

6 Aug 2026

Combining genetics and AI to discover new osteoarthritis drugs

Osteoarthritis (OA) is a chronic, painful joint disease and a leading cause of disability. Despite its prevalence, therapies for osteoarthritis are limited and focus on symptom management.

6 Aug 2026

Study identifies a novel direct drug target for head and neck squamous cell carcinoma

Chemotherapy remains a cornerstone of treatment for head and neck cancers, the seventh-most common cancer type worldwide.

6 Aug 2026

Circular RNAs offer new pathways to reduce cancer therapy side-effects

A new review highlights the growing importance of circular RNAs (circRNAs) in addressing one of the most pressing challenges in modern oncology: treatment-related toxicity.

6 Aug 2026

GLP-1 drug tirzepatide associated with lower risk of major cardiovascular events

Adding the GLP-1 receptor agonist drug tirzepatide (marketed as Mounjaro) to standard care for patients with type 2 diabetes and heart disease is associated with a lower risk of a major cardiovascular event, such as a heart attack or stroke, finds a study published by The BMJ today.

5 Aug 2026

Long-acting HIV prevention tools could help close the gap before a vaccine arrives

A review of non-vaccine HIV interventions highlights the strong preventive effects of long-acting PrEP, sustained ART, U=U, vertical transmission programs, and voluntary medical male circumcision. Gene editing and multispecific antibodies may expand future options, but safety, cost, access, adherence, and implementation barriers remain.

5 Aug 2026

Global surveys reveal little progress in tobacco risk awareness over two decades

Across 46 countries, adults who smoked showed high awareness that tobacco causes lung cancer but substantially lower knowledge of cardiovascular and secondhand smoke harms. Knowledge changed little overall across two decades, supporting stronger health warnings, mass media campaigns and enforced smoke-free policies.

5 Aug 2026

Scientists unmask immune cells that supercharge the fight against cancer

A little‑known group of hard-to-find immune cells could help transform cancer treatment, scientists at the University of Manchester’s Cancer Research UK Manchester Institute, have found.

5 Aug 2026

Mouse study shows how liraglutide briefly rewires gut bacterial communities

Researchers treated male high-fat-fed mice with liraglutide for 14 days, then tracked fecal bacterial communities after a 7-day washout using 16S rRNA sequencing. Liraglutide shifted the microbiome toward Lactobacillus- and Leptogranulimonas-related taxa while reducing several fermentative taxa, but most changes moved back toward baseline after treatment stopped.

4 Aug 2026

Large US trial supports silver diamine fluoride for severe early childhood caries

A phase 3 randomized trial of 830 young children with severe early childhood caries found that 38% silver diamine fluoride arrested 54.0% of eligible cavitated dentin lesions at six months, compared with 22.5% after placebo. The noninvasive treatment showed clinically meaningful efficacy, but about half of the lesions remained active, supporting close monitoring and additional preventive care.

3 Aug 2026

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Efficacy News and Research

LVIS stent-assisted coiling effectively treats wide-necked intracranial aneurysms

Comprehensive BMJ review identifies most effective bipolar disorder treatments

Bright-light therapy may reduce attention lapses during night work

Single-dose psilocybin shows promise for treatment-resistant depression in NHS trial

New drug delivers promising survival gains in pancreatic cancer

Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma

Plant-based nanoemulsion offers greener approach to pest control

Researchers find a new genetic vulnerability in acute myeloid leukemia

Scientists map key differences in stem cell potency for treating knee osteoarthritis

Genetic analysis of 1 million people points to FNIP1 as a promising metabolic target

D-serine promotes gastric cancer growth by suppressing tumor immunity

Combining genetics and AI to discover new osteoarthritis drugs

Study identifies a novel direct drug target for head and neck squamous cell carcinoma

Circular RNAs offer new pathways to reduce cancer therapy side-effects

GLP-1 drug tirzepatide associated with lower risk of major cardiovascular events

Long-acting HIV prevention tools could help close the gap before a vaccine arrives

Global surveys reveal little progress in tobacco risk awareness over two decades

Scientists unmask immune cells that supercharge the fight against cancer

Mouse study shows how liraglutide briefly rewires gut bacterial communities

Large US trial supports silver diamine fluoride for severe early childhood caries

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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