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New TSRI study may provide chance to target tumors before metastasis

New research from The Scripps Research Institute may give scientists a chance to target tumors before they metastasize.

9 Feb 2018

Scientists synthesize new multifunctional compound that has anti-tumor properties

A research team of the UNN Faculty of Chemistry led by Professor Alexei Fedorov has developed and synthesized a new multifunctional compound that possesses anti-tumor properties that are due to several independent effects.

2 Feb 2018

Geneva researchers highlight new way to control tumor progression

For a tumor to grow, it must develop blood vessels that supply nutrients and oxygen. Preventing tumor vascularization is therefore an interesting anti-tumor therapy that has been explored over the last ten years.

2 Feb 2018

Scientists discover new target for anti-angiogenic tumor therapy

Actively growing tumors have a high demand for oxygen and nutrients. Therefore, they stimulate the growth of blood vessels.

23 Jan 2018

Researchers block common siren call of glioblastoma and metastatic breast cancer

Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

23 Jan 2018

Scientists take tissue-engineering approach to improve healing related to skeletal system

"Take a knee." "On bended knee." A "knee-slapper." "The bee's knees." The knee certainly carries a lot of weight in the English language, just as it does in the body. As the largest and one of the most complicated joints, the knee is also one of the most easily injured.

23 Jan 2018

FDA grants approval for first drug to treat inherited breast cancer

The U.S. Food and Drug Administration today expanded the approved use of Lynparza (olaparib tablets) to include the treatment of patients with certain types of breast cancer that have spread (metastasized) and whose tumors have a specific inherited (germline) genetic mutation, making it the first drug in its class (PARP inhibitor) approved to treat breast cancer, and it is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a "BRCA" gene mutation.

15 Jan 2018

Administration of two proteins shown to counteract neurodegeneration in Parkinson's disease

A combination therapy made up of two neurotrophic factors can reduce the degenerative effects of Parkinson’s disease, shows new research.

15 Jan 2018

Synergy between two neurotrophic factors exerts beneficial effect in early phase of Parkinson’s disease

Parkinson's disease is currently the second most widespread neurogenerative pathology. Current therapies are mainly of a replacement type and pose problems in the long term, so the challenge is to establish an early diagnosis and develop neuroprotective and neurorestorative therapies that will allow the symptoms of the disease to be slowed down or even reversed.

12 Jan 2018

U.S. FDA approves first drug for patients with germline BRCA-mutated metastatic breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has approved LYNPARZA (olaparib) for use in patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer who have been previously treated with chemotherapy in the neoadjuvant, adjuvant or metastatic setting.

12 Jan 2018

UC scientists identify protein that acts as mediator of HER2-driven breast cancer

Researchers at the University of Cincinnati College of Medicine have identified for the first time that the estrogen receptor-binding protein MED1 is a critical mediator of HER2-driven breast cancer, identifying it as a potential therapeutic target.

9 Jan 2018

New drugs and screening techniques reduce breast cancer mortality rates, research shows

In the last few decades, dozens of new breast cancer drugs -- from chemotherapies to targeted compounds -- have become available for clinical use, and mammogram technology has gone from film to digital. But are the changes making a difference in how many women die of breast cancer?

9 Jan 2018

Researchers pinpoint mechanism for conversion of white fat into brown fat

An international team of researchers led from Karolinska Institutet have, in experiments on mice, pinpointed a mechanism for the conversion of energy-storing white fat into energy-expending brown fat.

5 Jan 2018

Study suggests potential means of stalling or even reversing diabetes-related blindness

Johns Hopkins researchers have discovered a cell signaling pathway in mice that triggers vision loss in patients with diabetic retinopathy and retinal vein occlusion – diseases characterized by the closure of blood vessels in the retina, leading to blindness.

3 Jan 2018

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

A drug developed for diabetes could be used to treat Alzheimer's after scientists found it "significantly reversed memory loss" in mice through a triple method of action.

2 Jan 2018

Study suggests new target to treat prostate cancer

Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.

22 Dec 2017

Tumor growth traits can influence response to cancer drugs, study finds

Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi School of Engineering finds that tumor growth properties can influence response to cancer drugs.

21 Dec 2017

Researchers identify novel mechanism that protects from brain tumor

A group of researchers at the Spanish National Cancer Research Centre have identified a protein called RanBP6 as a new regulator of EGFR. In a paper published in Nature Communications they show how silencing of RanBP6 promoted glioma growth, by upregulating EGFR expression.

18 Dec 2017

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Understanding how cancer cells are able to metastasize -- migrate from the primary tumor to distant sites in the body -- and developing therapies to inhibit this process are the focus of many laboratories around the country.

18 Dec 2017

Excessive copper in diabetes impedes ability to make new blood vessels

It's a metal we worry thieves will steal from our air conditioners or power lines, but inside our bodies too much copper can result in a much larger loss.

18 Dec 2017

Growth Factor News and Research

New TSRI study may provide chance to target tumors before metastasis

Scientists synthesize new multifunctional compound that has anti-tumor properties

Geneva researchers highlight new way to control tumor progression

Scientists discover new target for anti-angiogenic tumor therapy

Researchers block common siren call of glioblastoma and metastatic breast cancer

Scientists take tissue-engineering approach to improve healing related to skeletal system

FDA grants approval for first drug to treat inherited breast cancer

Administration of two proteins shown to counteract neurodegeneration in Parkinson's disease

Synergy between two neurotrophic factors exerts beneficial effect in early phase of Parkinson’s disease

U.S. FDA approves first drug for patients with germline BRCA-mutated metastatic breast cancer

UC scientists identify protein that acts as mediator of HER2-driven breast cancer

New drugs and screening techniques reduce breast cancer mortality rates, research shows

Researchers pinpoint mechanism for conversion of white fat into brown fat

Study suggests potential means of stalling or even reversing diabetes-related blindness

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

Study suggests new target to treat prostate cancer

Tumor growth traits can influence response to cancer drugs, study finds

Researchers identify novel mechanism that protects from brain tumor

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Excessive copper in diabetes impedes ability to make new blood vessels

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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