Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

Mass-spectrometry and PCR testing identifies various targets related to SARS-CoV-2 VOCs

New research posted to the medRxiv* preprint server suggests that the Agena MassARRAY SARS-CoV-2 Panel PCR test effectively detects a variety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

9 Dec 2021

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Continued replication of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) under selective pressure from natural and vaccine-induced immunity has led to the emergence of variants of concern (VOCs) with increased transmissibility or virulence.

8 Dec 2021

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Researchers from the United States, in their recent study published on the preprint server medRxiv*, have evaluated the humoral responses to third vaccine dose in nursing home residents and healthcare workers (HCW) and found that that second booster (or third vaccine dose) significantly increased anti-spike, anti-receptor binding domain (RBD), and neutralization titers in almost all nursing home residents and HCW to considerably higher levels than what was attained after the completion of the initial two-dose vaccine series.

8 Dec 2021

Study identifies several proteins that protect against disease development

Inflammatory processes are associated with a large range of human diseases, including rheumatic diseases and allergies. Protein biomarkers are measurable molecules that can have a prognostic value in patients, be used to diagnose disease, or indicate severity of disease.

8 Dec 2021

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

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8 Dec 2021

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

A collaborative team from the School of Medicine at the University of Cardiff, Wales and a range of US institutions used the UK's national synchrotron, Diamond Light Source, to help reveal the details of how a protein in the blood is attracted to a key component of Adenovirus based vaccines.

8 Dec 2021

Researchers identify a molecular culprit for COVID-19's seasonal nature

Not to pile on, but winter is coming and the COVID-19 pandemic is about to get worse. Not necessarily because of omicron – scientists are still working that one out – but because there’s more evidence than ever that COVID-19 is a seasonal disease.

8 Dec 2021

Earlier screening for rare genetic mutation could lead to faster treatment for heart failure in Black Americans

Researchers have linked a rare genetic mutation found mostly in Black Americans and other people of African descent to an earlier onset of heart failure and a higher risk of hospitalization.

8 Dec 2021

New hormone may play a key role in the development of type 1 and type 2 diabetes

A newly discovered hormone named fabkin helps regulate metabolism and may play an important role in the development of both type 1 and type 2 diabetes, according to research led by the Sabri Ülker Center for Metabolic Research at Harvard T.H. Chan School of Public Health.

8 Dec 2021

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

In a new study, scientists have computationally predicted the structure of the Omicron spike RBD from available sequences and explored the dynamics of antigen-antibody interactions.

8 Dec 2021

Researchers discover mechanism for congenital disorders of glycosylation

Greenwood Genetic Center researchers are reporting the discovery of a mechanism that contributes to the tissue phenotypes seen in PMM2-CDG, the most common of the congenital disorders of glycosylation (CDGs).

8 Dec 2021

Keto diet does not appear to work well for women

Scientists from UC Riverside are studying how the popular keto and intermittent fasting diets work on a molecular level, and whether both sexes benefit from them equally.

8 Dec 2021

Characterization of the baseline SARS-CoV-2 S-reactive B cell repertoire

Researchers from the University Of Amsterdam have identified several oddities in unvaccinated individuals' antibody response to the spike protein.

8 Dec 2021

Study identifies ORF8 protein as a key COVID-19 causing factor

New study suggests that the SARS-CoV-2 ORF8 protein is the underlying cause behind severe COVID-19 infection.

8 Dec 2021

Interactions between RNA viruses and human RNA-binding proteins

During the virus's attempt to use the host cell to replicate, host proteins interact heavily with the viral genome. Researchers have been investigating these interactions.

8 Dec 2021

SARS-CoV-2 antibody profiles in vaccinated and convalescent macaques compared to humans

New findings suggest that Macaque monkeys may not be the ideal model when testing for SARS-CoV-2.

8 Dec 2021

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

A team of researchers set out to build a full-length, membrane-embedded spike to study its conformational dynamics at the atomic level using molecular dynamics simulations to understand better how this important component of the virus machinery works.

8 Dec 2021

Breastmilk T cell repertoire is enriched for SARS-CoV-2 Spike-specificity after maternal mRNA vaccination

New study demonstrates that it is possible one day that breastmilk samples will be used to characterize broad mucosal immunity after vaccination.

8 Dec 2021

Brain injury markers associated with dysregulated immunological responses in COVID-19

Study shows that during hospitalization, patients with COVID-19 demonstrated elevated NfL and GFAP in a severity-dependant manner, as well as evidence of ongoing active brain injury 4 months later.

8 Dec 2021

Protein News and Research

Further Reading

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

Mass-spectrometry and PCR testing identifies various targets related to SARS-CoV-2 VOCs

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Study identifies several proteins that protect against disease development

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

Researchers identify a molecular culprit for COVID-19's seasonal nature

Earlier screening for rare genetic mutation could lead to faster treatment for heart failure in Black Americans

New hormone may play a key role in the development of type 1 and type 2 diabetes

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

Researchers discover mechanism for congenital disorders of glycosylation

Keto diet does not appear to work well for women

Characterization of the baseline SARS-CoV-2 S-reactive B cell repertoire

Study identifies ORF8 protein as a key COVID-19 causing factor

Interactions between RNA viruses and human RNA-binding proteins

SARS-CoV-2 antibody profiles in vaccinated and convalescent macaques compared to humans

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

Breastmilk T cell repertoire is enriched for SARS-CoV-2 Spike-specificity after maternal mRNA vaccination

Brain injury markers associated with dysregulated immunological responses in COVID-19

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