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ASU researchers uncover crucial step in telomerase enzyme catalytic cycle

Can we stay young forever, or even recapture lost youth? Research from the laboratory of Professor Julian Chen in the School of Molecular Sciences at Arizona State University recently uncovered a crucial step in the telomerase enzyme catalytic cycle.

27 Feb 2018

Researchers develop new tool that provides 3D view of metabolic processes

An international team of researchers has developed a computational resource that provides a 3D view of genes, proteins and metabolites involved in human metabolism.

27 Feb 2018

Combined analysis makes risk prediction for colorectal cancer more precise

If first-degree relatives are affected by colorectal cancer, this indicates a person's own elevated risk of developing bowel cancer. The same holds true for people who have large numbers of genetic risk markers in their genome.

26 Feb 2018

Scientists reveal new insights into mechanism of gene regulation by 'magic spot'

Using an innovative crystallization technique for studying three-dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the "magic spot"--a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

24 Feb 2018

Study reveals functional dynamics of ion channels

Most ion channels are very selective about the ions, which may or may not pass through them. They may be conductive for potassium ions and non-conductive for sodium ions or vice versa.

19 Feb 2018

Scientists design new triple labeling technique to analyze stem cell division

A joint team of scientists from Russia and the United States designed a method for marking dividing stem cells with three different labels.

8 Feb 2018

Exploring the Future of Breast Cancer Risk Assessment

An interview with Dr Gareth Evans about the future of breast cancer screening and the implementation of single nucleotide polymorphism (SNP) profiling.

1 Feb 2018

Groundbreaking study broadens spectrum of cryopyrin-associated periodic syndromes

A research team from the University of Helsinki, Helsinki University Hospital and Folkhälsan Institute of Genetics in Helsinki, Finland, have identified a new genetic mutation that alters the function of cryopyrin and leads to a life-long periodic inflammation of the cornea, the transparent window of the human eye. Patients who carry the mutation also develop corneal opacities that compromise vision.

29 Jan 2018

Scientists aim to decipher language of DNA

Yes, DNA has its own language and scientists want to understand it to apply personalized therapeutic solutions based on the analysis of the individual's genomic biomarkers and their regulation.

24 Jan 2018

Genetic study identifies six new gene regions associated with type 1 diabetes in children

This article outlines a recent study which identified six novel gene regions in children who are at risk of type 1 diabetes.

17 Jan 2018

Scientists identify six new gene regions that may help treat type 1 diabetes

Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating or even preventing it.

17 Jan 2018

Novel polygenic hazard score captures age variations of aggressive prostate cancer

An international team, led by researchers at the University of California San Diego School of Medicine, has developed and validated a genetic tool for predicting age of onset of aggressive prostate cancer, a disease that kills more than 26,000 American men annually.

12 Jan 2018

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

Research led by Ludwine Messiaen, Ph.D., professor of genetics at the University of Alabama at Birmingham, shows that missense mutations in a cluster of just five codons in the NF1 gene are an important risk factor for severe symptoms of the genetic disease neurofibromatosis type 1.

28 Dec 2017

$Study uncovers genomic targets in refractory neuroblastoma$

Study uncovers genomic targets in refractory neuroblastoma

Neuroblastoma (NB) is the most common solid tumor found in children. It starts in some very early forms of nerve cells found in the embryo or fetus.

28 Dec 2017

Inherited gene variation may be to blame for poor survival of patients with early-onset breast cancer

A new study led by scientists at the University of Southampton has found that inherited variation in a particular gene may be to blame for the lower survival rate of patients diagnosed with early-onset breast cancer.

14 Dec 2017

Researchers reveal pathological mechanisms in congenital myotonic dystrophy

Myotonic dystrophy (DM) is the most common form of genetic muscular dystrophy that begins in adulthood. DM is characterized by progressive muscle wasting and weakness. People with this disorder often have prolonged muscle contractions (myotonic) and are not able to relax certain muscles after use.

12 Dec 2017

Simple molecular test may help predict presence of high-grade pancreatic cancers

A report in The Journal of Molecular Diagnostics, describes a new simple molecular test to detect chromosomal abnormalities -- biomarkers known as telomere fusions--in pancreatic tumor specimens and pancreatic cyst fluids.

8 Dec 2017

Genetic susceptibility to BD can increase suicide risk among people exposed to traumatic stress

Genetic susceptibility to bipolar disorder can increase the risk for suicide attempt, but only among those who also have experienced traumatic stress, reports a study published in the December 2017 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

4 Dec 2017

Study focuses on improving pharmacokinetic properties of therapeutic aptamers

Designing new therapeutic DNA aptamers with diverse side chains can improve their ability to interact with targets, and a new study describes characteristics of these side chains that may determine how long the aptamers remain in the bloodstream.

30 Nov 2017

Research findings will help identify genetic causes of brain disorders

New findings will help to identify the genetic causes of brain disorders: researchers at the Universities of Basel, Bonn and Cologne have presented a systematic catalog of specific variable locations in the genome that influence gene activity in the human hippocampus, as they report in the journal Nature Communications.

27 Nov 2017