Protein C News and Research

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GlyNAC could improve many age-associated defects in older humans

A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC - a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione - could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging.

29 Mar 2021

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability.

29 Mar 2021

UVA-led researchers urge rapid action to better prepare for the next pandemic

An international team of researchers led by a University of Virginia School of Medicine professor is warning that scientists must better prepare for the next pandemic - and has developed a plan to do just that.

29 Mar 2021

Pfizer-BioNTech vaccine causes steep drop in COVID-19 among healthcare workers

A team of scientists from Spain has recently evaluated the efficacy of an mRNA-based COVID-19 vaccine developed by Pfizer-BioNTech (BNT162b2). Their findings reveal that a 2-dose regimen of BNT162b2 vaccine is capable of providing almost 100% protection against SARS-CoV-2 infection in healthcare workers.

29 Mar 2021

Antibody for uterine sensitization associated gene-1 can stimulate tooth growth in mice

The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the pillow, but the child can be assured of a new tooth in a few months. The same cannot be said of adults who have lost their teeth.

29 Mar 2021

GBP5 protein may play a key role in suppressing inflammation in rheumatoid arthritis

New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system mistakenly attacks the body's own joint tissues.

29 Mar 2021

Researchers examine circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2

New research published in Briefings in Bioinformaticsm has identified thousands of circRNAs in Betacoronaviruses, including MERS-CoV, SARS-CoV-1, and SARS-CoV-2, from the RNA-sequencing data of viral infections. These coronaviruses have a similar genomic structure with a diverse circRNA coding ability. Researchers have also systematically characterized circRNAs in coronaviruses, with regard to their size, sequence feature, expressions, genome, location preference, and functions. This opens the door to further explore and understand the mode of action of individual circRNAs in coronaviruses.

29 Mar 2021

Researchers develop novel nanoadjuvant COVID-19 vaccine candidate

Researchers at the National Center for Nanoscience and Technology of China, the Chinese Academy of Sciences (CAS), introduced a new vaccine, which compromises the spike protein’s receptor-binding domain (RBD) and the manganese nanoadjuvant (MnARK), inducing humoral and cellular responses.

29 Mar 2021

Study identifies key features in SARS-CoV-2 genome essential for replication in respiratory cells

Researchers at the Institute of Medical Virology, the University of Zurich in Switzerland, have identified features in the SARS-CoV-2 genome that are important for human respiratory cell growth.

29 Mar 2021

Addressing the increasing plasticity of SARS-CoV-2

Researchers summarize what this rapid increase of plasticity of SARS-CoV-2 could mean for the future of the pandemic and anti-SARS-CoV-2 measures.

29 Mar 2021

Virus-cell interaction may partly explain the higher infection rate of COVID-19

Bioengineering researchers at Lehigh University have identified a previously unknown interaction between receptors in human cells and the spike, or "S," protein of SARS-CoV-2, the virus that causes COVID-19.

29 Mar 2021

Single Sputnik V vaccine dose elicits robust immune response in previously infected individuals

A new preprint research paper posted to the medRxiv server describes successful immunization of the vaccinated population with a single dose of the Russian-made Sputnik V vaccine.

29 Mar 2021

Linear epitope mapping of the SARS-CoV-2 spike protein

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the primary target of many drug discovery efforts and is similarly utilized in each of the approved COVID-19 vaccines to elicit the generation of anti-spike protein antibodies, thereby granting immunity.

28 Mar 2021

Boerhavia diffusa possess potential therapeutic properties against COVID-19

Several companies and research groups have been searching for suitably docking ligands that inhibit the function of this protein. In a research paper recently published to the Springer journal VirusDisease by Surya & Praveen (March 6th, 2021) in silico docking simulations towards 3CLpro have been performed, focusing in particular on natural products obtained from the plant Boerhavia diffusa.

28 Mar 2021

Antibody agents effective at neutralizing European, South African, and United States SARS-CoV-2 variants

Researchers in the United States have demonstrated the effectiveness of three antibody agents at neutralizing recently emerged variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic.

28 Mar 2021