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Research provides insights into how Zika virus can spread through sexual contact

Zika virus is capable of replicating and spreading infectious particles within the outermost cells lining the vaginal tract, according to new research. The findings provide the first molecular-level insights into how the virus can move from person to person through sexual contact.

27 Apr 2020

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Overreaction is rarely useful, and in the case of the human immune system, it can be outright deadly. When the body overreacts to an infection, the result is sepsis - a life-threatening condition that frequently leads to acute organ dysfunction, including deterioration of the heart and blood vessels, which make up the cardiovascular system.

24 Apr 2020

Researchers discover physiological mechanisms underlying pediatric B-ALL

B-cell acute lymphoblastic leukemia (B-ALL) is characterized by the accumulation of abnormal immature B-cell precursors in the bone marrow and is the most common pediatric cancer.

23 Apr 2020

Study finds how metabolism regulates sleep in worms

Can staying up late make you fat? A growing body of research has suggested that poor sleep quality is linked to an increased risk of obesity by deregulating appetite, which in turn leads to more calorie consumption.

21 Apr 2020

Discovery could open door to the development of new anti-cancer drugs

A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer.

20 Apr 2020

A new combinatorial therapy for treatment of liver cancer

In the latest issue of Molecular Therapy, Skoltech and MIT researchers have published a new combinatorial therapy for the treatment of liver cancer.

20 Apr 2020

Activating a braking mechanism against cancer

A team has identified the binding site where drug compounds could activate a braking mechanism against runaway growth of cancer.

20 Apr 2020

Molecular pathway that controls immunosuppression in tumors identified

An active immune system plays an important role in stopping cancer progression by identifying tumor cells and targeting them for destruction. Any deviation in the normal activities of the immune system could lead to accelerated tumor growth.

14 Apr 2020

Voluntary exercise could help prevent liver cancer, study shows

Liver cancer is the fourth most common cause of cancer death worldwide and is growing rapidly due to the "diabesity pandemic."

14 Apr 2020

Researchers pinpoint genetic variation responsible for development of IBD

Researchers at Children's Hospital of Philadelphia have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease.

9 Apr 2020

Researchers discover inflammatory mechanism that contributes to autoimmune diseases

The protein STING (Stimulator of Interferon Genes) is a critical component of the body's innate immune defence system, but can also contribute to chronic autoimmune and autoinflammatory diseases.

8 Apr 2020

Majority of patients with mantle cell lymphoma may benefit from CAR T-cell therapy KTE-X19

A one-year follow-up study led by The University of Texas MD Anderson Cancer Center revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) T-cell therapy.

1 Apr 2020

Gene that could affect the progress of ALS discovered

Researchers from the Zuckerman Institute at Columbia University have successfully found a gene that could work towards accelerating the progression of ALS or amyotrophic lateral sclerosis. The study titled, "The loss of TBK1 kinase activity in motor neurons or in all cell types differentially impacts ALS disease progression in SOD1 mice," was published in the latest issue of the journal Neuron.

29 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Research may help older adults maintain skeletal muscle mass and physical function for longer

Drug therapies that help older adults maintain their skeletal muscle mass and physical function for longer could be a step closer after researchers at the University of Birmingham identify a key mechanism that drives the clearance of damaged mitochondria.

22 Mar 2020

Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly monitored during the first month of therapy.

22 Mar 2020

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors.

21 Mar 2020

Kinase News and Research

Research provides insights into how Zika virus can spread through sexual contact

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Researchers discover physiological mechanisms underlying pediatric B-ALL

Study finds how metabolism regulates sleep in worms

Discovery could open door to the development of new anti-cancer drugs

A new combinatorial therapy for treatment of liver cancer

Activating a braking mechanism against cancer

Molecular pathway that controls immunosuppression in tumors identified

Voluntary exercise could help prevent liver cancer, study shows

Researchers pinpoint genetic variation responsible for development of IBD

Researchers discover inflammatory mechanism that contributes to autoimmune diseases

Majority of patients with mantle cell lymphoma may benefit from CAR T-cell therapy KTE-X19

Gene that could affect the progress of ALS discovered

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Research may help older adults maintain skeletal muscle mass and physical function for longer

Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Singapore researchers find common therapeutic vulnerability for a deadly blood cancer

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

Scientists identify genes involved in the development of diabetic kidney disease

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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