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Protein, macrophage migration inhibitory factor predicts heart attack response and cardiac damage

A protein has been found that influences the response of the heart to a lack of oxygen and blood flow, such as occurs during a heart attack, a team of Yale School of Medicine researchers report in Nature.

4 Feb 2008

Enzyme released by mast cells in the lungs could be a new target for asthma

An enzyme released by mast cells in the lungs appears to play a key role in the tightening of airways that is a hallmark of asthma pointing to a potential new target for treatment against the illness.

4 Feb 2008

Lungs' mast cells could provide new treatment target for asthma, other respiratory disease

30 Jan 2008

Kidney cancer drug attacks a major type of acute myeloid leukemia

A drug used to treat kidney cancer also targets a genetic mutation active in about one third of patients with acute myeloid leukemia (AML), the most common and lethal form of adult leukemia, researchers at The University of Texas M. D. Anderson Cancer Center report in the Jan. 29 edition of the Journal of the National Cancer Institute.

30 Jan 2008

New target found for asthma

An enzyme released by mast cells in the lungs appears to play a key role in the tightening of airways that is a hallmark of asthma -- pointing to a potential new target for treatment against the illness.

29 Jan 2008

Evidence strongly supports diuretics as initial metabolic syndrome therapy, especially in black patients

New research shows that in people with high blood pressure as part of metabolic syndrome, a cluster of conditions that increases the risk for heart disease, diuretics offer greater protection against cardiovascular disease, including heart failure, and are at least as effective for lowering blood pressure as newer, more expensive medications.

28 Jan 2008

Weakness found in anthrax bacterium

MIT and New York University researchers have identified a weakness in the defenses of the anthrax bacterium that could be exploited to produce new antibiotics.

25 Jan 2008

Search for the 'on' switches may reveal genetic role in development and disease

A new resource that identifies regions of the human genome that regulate gene expression may help scientists learn about and develop treatments for a number of human diseases, according to researchers at Duke's Institute for Genome Sciences & Policy (IGSP).

25 Jan 2008

Celebrex may disrupt heart rhythm

Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a novel pathway unrelated to its COX-2 inhibition.

25 Jan 2008

Elusive pancreatic stem cells found in adult mice

Just as many scientists had given up the search, researchers have discovered that the pancreas does indeed harbor stem cells with the capacity to generate new insulin-producing beta cells.

25 Jan 2008

New method for measuring protein synthesis

In a major breakthrough for future research and drug development, a team of Los Angeles Biomedical Research Institute (LA BioMed) investigators developed a new, more reliable method for measuring protein synthesis and turnover, processes that are critical to understanding cellular functions.

23 Jan 2008

Gene variations associated with effectiveness of blood pressure medications

Patients with hypertension and certain gene variations experienced varying results with some blood pressure medications, suggesting matching a patient's genotype with certain hypertension medications could result in more favorable outcomes, according to a study in the January 23 issue of JAMA: The Journal of the American Medical Association.

23 Jan 2008

FDA approves etravirine tablets for HIV

The U.S. Food and Drug Administration has approved etravirine tablets for the treatment of HIV infection in adults who have failed treatment with other antiretrovirals.

21 Jan 2008

Sleep plays a critical role in the brain's ability to learn

Most people know it from experience: After so many hours of being awake, your brain feels unable to absorb any more-and several hours of sleep will refresh it.

21 Jan 2008

New HIV drug will help millions

Statistics released by the World Health Organisation (WHO) indicate that as many as 33 million people worldwide are currently living with the HIV virus which also killed 2 million people in 2007.

20 Jan 2008

Scientists uncover role of cancer stem cell marker: controlling gene expression

Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread.

18 Jan 2008

Altering brain's lipid metabolism reduces Alzheimer's plaques in mice

Increasing levels of a protein that helps the brain use cholesterol may slow the development of Alzheimer's disease changes in the brain, according to researchers studying a mouse model of the disease at Washington University School of Medicine in St. Louis.

18 Jan 2008

An emerging candidate for protecting patients from liver injury after abdomen surgery

Many patients worldwide are going to receive major abdomen surgery or intestine transplantation every year and expect to be afflicted with liver injury afterwards.

17 Jan 2008

Smart hydrogel particles: biomarker harvesting

The long and challenging effort to find blood-borne markers for cancer and other diseases may soon enter a new realm of success using a new nanoparticle that preferentially and rapidly removes small proteins and other molecules from blood while simultaneously protecting them from degradation.

16 Jan 2008