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Researchers create combination drug that controls both tumor growth and metastasis

Researchers at UC Davis, University of Massachusetts and Harvard Medical School have created a combination drug that controls both tumor growth and metastasis. By combining a COX-2 inhibitor, similar to Celebrex, and an epoxide hydrolase (sEH) inhibitor, the drug controls angiogenesis (blood vessel formation), limiting a tumor's ability to grow and spread.

14 Jul 2014

Pareto partners with DNA2.0 to develop technology for quick-to-market products

Synthetic biology company Pareto Biotechnologies today announces a technology partnership with global bioengineering leader DNA2.0, enabling Pareto to further develop its technology for quick-to-market products.

14 Jul 2014

Research roundup: Clinics and electronic records; young adults baffled by exchange; Medicare spending slowdown

We found that in 2012 nine out of ten health centers had adopted a EHR system, and half had adopted EHRs with basic capabilities. Seven in ten health centers reported that their providers were receiving meaningful-use incentive payments from the Centers for Medicare and Medicaid Services (CMS).

14 Jul 2014

CYD-TDV vaccine shows moderate protection against dengue in Asian children

The first dengue vaccine candidate (CYD-TDV) to reach phase 3 clinical testing has shown moderate protection (56%) against the disease in Asian children, according to new research published in The Lancet.

14 Jul 2014

"Expressive therapy" intervention helps HIV women, improves social support

New research from UC San Francisco shows that an "expressive therapy" group intervention conducted by The Medea Project helps women living with HIV disclose their health status and improves their social support, self-efficacy and the safety and quality of their relationships.

14 Jul 2014

New chemical compound protects against blindness and diabetes in animals

In a new study led by UC San Francisco scientists, a chemical compound designed to precisely target part of a crucial cellular quality-control network provided significant protection, in rats and mice, against degenerative forms of blindness and diabetes.

11 Jul 2014

New approach for developing personalized gene therapies to treat retinitis pigmentosa

Columbia University Medical Center researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss.

11 Jul 2014

New drug delivered through skin effective in treatment of breast cancer

A drug that has proven effective in the prevention and treatment of breast cancer, but with serious side-effects, may be delivered effectively through the skin using a new topical drug-delivery system.

11 Jul 2014

Penn receives $8 million grant from NCI to study effects of PDT

Researchers at the Perelman School of Medicine at the University of Pennsylvania in collaboration with the Roswell Park Cancer Institute have received an $8 million grant from the National Cancer Institute (NCI) to study the effects of photodynamic light therapy (PDT) in patients with malignant pleural mesothelioma, a rare, aggressive and deadly cancer that most often manifests itself in the lining of the lungs and is caused almost exclusively by exposure to asbestos.

10 Jul 2014

Pharmalink’s core patents for Nefecon issued in United States, Europe, China and Hong Kong

Pharmalink AB, a specialty pharma company focused on orphan and niche products, has had core patents for its late-stage clinical candidate Nefecon® issued in the key markets United States, Europe, China and Hong Kong. A patent is pending in Japan.

10 Jul 2014

Fecal transplantation safe, effective for treating C. difficile in immunocompromised patients

Researchers have found that fecal transplantation is effective and safe for treating C. difficile in immunocompromised patients. This is the result of a study led by Colleen Kelly, M.D., a gastroenterologist in the Center for Women's Gastrointestinal Medicine at The Women's Medicine Collaborative.

10 Jul 2014

Researchers receive $8 million NCI grant to study effects of PDT in patients with mesothelioma

Researchers at the Perelman School of Medicine at the University of Pennsylvania in collaboration with the Roswell Park Cancer Institute have received an $8 million grant from the National Cancer Institute to study the effects of photodynamic light therapy (PDT) in patients with malignant pleural mesothelioma, a rare, aggressive and deadly cancer that most often manifests itself in the lining of the lungs and is caused almost exclusively by exposure to asbestos.

10 Jul 2014

Regeneron, Sanofi report positive results from dupilumab Phase 2b study in moderate-to-severe AD

Regeneron Pharmaceuticals, Inc. and Sanofi today announced positive results from a Phase 2b dose-ranging study of dupilumab, an investigational therapy, in adult patients with moderate-to-severe atopic dermatitis (AD), a serious, chronic form of eczema.

10 Jul 2014

New therapeutic targets release mechanisms in reactive astrocytes for treatment of Alzheimer's disease

Alzheimer's disease, which is the most common cause of dementia, is fatal and currently, there is no cure. In Alzheimer's disease, brain cells are damaged and destroyed, leading to devastating memory loss.

9 Jul 2014

Antibiotic treatment for patients who underwent gall bladder removal does not reduce infection risk

Among patients who underwent gall bladder removal for acute calculous cholecystitis, lack of postoperative antibiotic treatment did not result in a greater incidence of infections, according to a study in the July 9 issue of JAMA.

9 Jul 2014

Over 650 000 children develop tuberculosis every year in the 22 HBCs according to new estimates

New estimates indicate that over 650 000 children develop tuberculosis (TB) every year in the 22 countries with a high burden of the disease (HBCs)*—almost 25% higher than the total number of new cases worldwide estimated by WHO in 2012 (530 000)**. The research, published in The Lancet Global Health, also suggests that about 15 million children are exposed to TB every year, and roughly 53 million are living with latent TB infection, which can progress to infectious active TB at any time.

9 Jul 2014

Combining NRT with varenicline improves smoking abstinence

Combining the smoking cessation medication varenicline with nicotine replacement therapy was more effective than varenicline alone at achieving tobacco abstinence at 6 months, according to a study in the July 9 issue of JAMA.

8 Jul 2014

KoACT supplement optimal for bone strength, flexibility in post-menopausal women

Data presented at April's Experimental Biology 2014 Annual Scientific Meeting shows that KoACT, a dietary supplement that combines a proprietary formulation of calcium and collagen is optimal for bone strength and flexibility in post-menopausal women.

8 Jul 2014

Cheaper drug could potentially improve heart attack patient outcomes and save health services millions

A new study published in The Lancet compares outcomes for two drugs used to prevent blood clot formation during emergency heart attack treatment. The study suggests that use of one of the drugs, heparin, could result in improved outcomes (such as a reduced rate of repeat heart attacks), compared to the other drug tested, bivalirudin, which is in widespread use in high-income countries, and is around 400 times more expensive than heparin.

7 Jul 2014

AutoGenomics, Genomas sign agreement to develop DNA-guided diagnostic systems

AutoGenomics, Inc, a leader in automated microarray technology for molecular diagnostics, and Genomas, a biomedical company enabling DNA-guided medicine for personal healthcare, announced today that they have signed an agreement to jointly develop genetic tests and DNA-guided diagnostic systems for optimal selection of statins and for improved delivery of statin therapy for the treatment of cardiovascular disease, obesity and diabetes.

7 Jul 2014

Efficacy News and Research

Researchers create combination drug that controls both tumor growth and metastasis

Pareto partners with DNA2.0 to develop technology for quick-to-market products

Research roundup: Clinics and electronic records; young adults baffled by exchange; Medicare spending slowdown

CYD-TDV vaccine shows moderate protection against dengue in Asian children

"Expressive therapy" intervention helps HIV women, improves social support

New chemical compound protects against blindness and diabetes in animals

New approach for developing personalized gene therapies to treat retinitis pigmentosa

New drug delivered through skin effective in treatment of breast cancer

Penn receives $8 million grant from NCI to study effects of PDT

Pharmalink’s core patents for Nefecon issued in United States, Europe, China and Hong Kong

Fecal transplantation safe, effective for treating C. difficile in immunocompromised patients

Researchers receive $8 million NCI grant to study effects of PDT in patients with mesothelioma

Regeneron, Sanofi report positive results from dupilumab Phase 2b study in moderate-to-severe AD

New therapeutic targets release mechanisms in reactive astrocytes for treatment of Alzheimer's disease

Antibiotic treatment for patients who underwent gall bladder removal does not reduce infection risk

Over 650 000 children develop tuberculosis every year in the 22 HBCs according to new estimates

Combining NRT with varenicline improves smoking abstinence

KoACT supplement optimal for bone strength, flexibility in post-menopausal women

Cheaper drug could potentially improve heart attack patient outcomes and save health services millions

AutoGenomics, Genomas sign agreement to develop DNA-guided diagnostic systems

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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