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Amicus to present additional positive data from Amigal Phase 2 extension study for Fabry disease

Amicus Therapeutics today announced that additional positive data from the ongoing Phase 2 extension study of its investigational drug Amigal™ (migalastat HCl) for Fabry disease will be presented at the Lysosomal Disease Network WORLD Symposium in Las Vegas, Nevada, February 16-18th, 2011.

17 Feb 2011

Vical announces issuance of U.S. Patent for cytomegalovirus vaccines

Vical Incorporated announced today the issuance of U.S. Patent No. 7,888,112 covering DNA vaccines for cytomegalovirus containing specific gene sequences and formulated with Vical's Vaxfectin adjuvant.

16 Feb 2011

Bone remodeling inflammatory protein linked to metastatic lung cancer development in mice with breast cancer

When doctors discover high concentrations of regulatory T cells in the tumors of breast cancer patients, the prognosis is often grim, though why exactly has long been unclear.

16 Feb 2011

Study explores role of proline containing peptides in inhibiting anti-apoptotic function of XIAP

Basic and translational research on cancer, and development of new cancer therapeutics, has focused on different aspects of cancer cellular function. One area of focus is the life and death of a cancer cell. Apoptosis, also known as programmed cell death, is a fundamental process of cells including cancer cells. The signal transduction pathways of apoptosis involve many different proteins and their interactions with each other.

16 Feb 2011

Deactivation of tau gene may help reverse memory loss in Alzheimer disease

Amyloid-beta and tau protein deposits in the brain are characteristic features of Alzheimer disease. The effect on the hippocampus, the area of the brain that plays a central role in learning and memory, is particularly severe. However, it appears that the toxic effect of tau protein is largely eliminated when the corresponding tau gene is switched off.

16 Feb 2011

Genetic proof for anti-cancer properties of antioxidants and autophagy inhibitors

Researchers from Jefferson's Kimmel Cancer Center have genetic evidence suggesting the antioxidant drugs currently used to treat lung disease, malaria and even the common cold can also help prevent and treat cancers because they fight against mitochondrial oxidative stress-a culprit in driving tumor growth.

16 Feb 2011

Research: Way heart responds to early beat is predictive of cardiac death

The way the heart responds to an early beat is predictive of cardiac death, especially for people with no conventional markers of cardiovascular disease, according to new research from Washington University School of Medicine in St. Louis.

16 Feb 2011

Pfenex enters strategic agreement with Boehringer Ingelheim for use of Expression Technology

Pfenex Inc., an industry leader in protein expression through the Pfenex Expression Technology platform and Boehringer Ingelheim International GmbH, a leading pharmaceutical company and global leader in biopharmaceutical contract development and manufacture, announced today that they have entered into a strategic agreement.

16 Feb 2011

Study: Overexpression of EZH2 protein promotes breast cancer progression

An essential protein for normal stem cell renewal also promotes the growth of breast cancer stem cells when it's overproduced in those cells, researchers at The University of Texas MD Anderson Cancer Center report in the February edition of Cancer Cell.

16 Feb 2011

Study: Heart rate turbulence is linked with increased risk of death from cardiovascular disease

Abnormal heart rate turbulence is associated with an increased risk of heart disease death in otherwise low-risk older individuals, according to a study funded by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health.

15 Feb 2011

The Lancet publishes Baxter's PREFLUCEL phase III trial results against seasonal influenza

Baxter International Inc. announced today results of a study published in this week's issue of The Lancet that demonstrate effectiveness and tolerability of Baxter's PREFLUCEL in protecting against seasonal influenza.

From Baxter International Inc. 15 Feb 2011

RPCI offers first FDA-approved cancer treatment vaccine

The nation's first FDA-approved cancer treatment vaccine, Provenge, is being offered for the first time in Western New York at Roswell Park Cancer Institute.

15 Feb 2011

Research: MEF2D protein in mitochondria appears to contribute early steps in Parkinson's disease

For the last several years, neurologists have been probing a connection between Parkinson's disease and problems with mitochondria, the miniature power plants of the cell.

15 Feb 2011

Idera: IMO-3100 in lupus preclinical model suppressed several key disease progression parameters

Idera Pharmaceuticals, Inc. announced today that it is presenting data on IMO-3100, an antagonist of TLR7 and TLR9, in a preclinical model of lupus showing that treatment with IMO-3100 suppressed several key disease progression parameters.

15 Feb 2011

New research finds differences in cell fate commitment during embryonic development in mammals

New research shows that all not mammals are created equal. In fact, this work shows that the animals most commonly used by scientists to study mammalian genetics -- mice -- develop unusually quickly and may not always be representative of embryonic development in other mammals.

15 Feb 2011

Scientists find molecular pathway that offers novel targets for diabetes therapies

Once people develop type 2 diabetes, high blood glucose levels alter their metabolism so much that it becomes difficult to sift through all the clues to find what might enable the disease.

15 Feb 2011

Researchers use computers to capture chemical signal structure that triggers metastatic cancer

In cancer and other pathological diseases, researchers are discovering that packaging is important: specifically, how DNA - about two meters long when unwound and stretched - coils up and compacts neatly inside the nucleus of a cell.

15 Feb 2011

Hunk protein inhibition might provide new approach to treat HER2-positive breast cancer

Among women with breast cancer, approximately 25% have a subtype that is characterized by high levels of expression of the protein HER2. HER2-positive breast cancer tends to be more aggressive than other breast cancer subtypes.

15 Feb 2011

Researcher discovers mechanism how p53 human genome gets inactivated in cancerous cells

One of the most important genes in the human genome is called p53 and its function is to suppress tumours, according to Roger Leng, a researcher in the Faculty of Medicine & Dentistry. Leng has discovered the mechanism by which p53 is inactivated in cancerous cells, allowing tumours to grow.

15 Feb 2011

Molecular helper Spy aids designer bacteria to produce large quantities of stable, functional proteins

Scientists have discovered a molecular assistant called Spy that helps bacteria excel at producing proteins for medical and industrial purposes.

15 Feb 2011

G Protein News and Research

Amicus to present additional positive data from Amigal Phase 2 extension study for Fabry disease

Vical announces issuance of U.S. Patent for cytomegalovirus vaccines

Bone remodeling inflammatory protein linked to metastatic lung cancer development in mice with breast cancer

Study explores role of proline containing peptides in inhibiting anti-apoptotic function of XIAP

Deactivation of tau gene may help reverse memory loss in Alzheimer disease

Genetic proof for anti-cancer properties of antioxidants and autophagy inhibitors

Research: Way heart responds to early beat is predictive of cardiac death

Pfenex enters strategic agreement with Boehringer Ingelheim for use of Expression Technology

Study: Overexpression of EZH2 protein promotes breast cancer progression

Study: Heart rate turbulence is linked with increased risk of death from cardiovascular disease

The Lancet publishes Baxter's PREFLUCEL phase III trial results against seasonal influenza

RPCI offers first FDA-approved cancer treatment vaccine

Research: MEF2D protein in mitochondria appears to contribute early steps in Parkinson's disease

Idera: IMO-3100 in lupus preclinical model suppressed several key disease progression parameters

New research finds differences in cell fate commitment during embryonic development in mammals

Scientists find molecular pathway that offers novel targets for diabetes therapies

Researchers use computers to capture chemical signal structure that triggers metastatic cancer

Hunk protein inhibition might provide new approach to treat HER2-positive breast cancer

Researcher discovers mechanism how p53 human genome gets inactivated in cancerous cells

Molecular helper Spy aids designer bacteria to produce large quantities of stable, functional proteins

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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