Enzyme News and Research

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New insight into mechanism of DNA-break repair

A new UC Davis study that explains the actions of a gene mutation that causes early onset cancer provides a fundamental insight into the mechanism of DNA-break repair.

6 Aug 2007

What causes rosacea?

Doctors can describe the symptoms of rosacea, a common inflammatory skin disease that causes facial redness and affects nearly 14 million Americans.

6 Aug 2007

Rosacea the result of a trifecta of unfortunate factors

Rosacea is a common inflammatory skin disease that causes facial redness which affects as many as 14 million Americans.

6 Aug 2007

Innovative gene therapy research for muscular dystrophy

A major grant of approximately $10 million from the National Institutes of Health will help investigators at Columbus Children's Research Institute (CCRI) at Columbus Children's Hospital learn more about strategies to treat muscular dystrophy, potentially leading to two new gene therapy approaches.

3 Aug 2007

New understanding of male fertility from enzyme discovery

Scientists have discovered a new enzyme involved in the degradation of proteins inside cells, a process that helps eliminate or recycle proteins that are no longer needed.

3 Aug 2007

Possible anthrax drug targets

In the American government's biodefense efforts, the potential for terrorists to cause a deadly anthrax outbreak remains a significant concern, six years after the letter attacks that shook the nation shortly after 9/11.

3 Aug 2007

Ibuprofen improves cognitive function in rats induced with chronic liver failure

Cognitive impairment is one of the neurological effects in patients with hepatic encephalopathy (abnormal brain function due to severe liver disease).

2 Aug 2007

Nimesulide delays pancreatic cancer precursors in mice

Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA.

2 Aug 2007

Coffee and liver cancer

After lung and stomach cancer, liver cancer is the third largest cause of cancer deaths in the world.

2 Aug 2007

COX-2 inhibitors delay pancreatic cancer precursors in mice

Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA.

1 Aug 2007

Drugs designed to disable enzyme TOPK could have anti-cancer benefits

Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death.

1 Aug 2007

Discovery of pathway that controls cell size and division

Organisms precisely regulate cell size to ensure that daughter cells have sufficient cellular material to thrive or to create specific cell types: a tiny sperm versus a gargantuan egg for example.

1 Aug 2007

Shutting off a critical cancer gene causes cancers in mice to self-destruct

Killing cancerous tumors isn't easy, as anyone who has suffered through chemotherapy can attest.

1 Aug 2007

Chromosomes responsible for a critical enzyme's activation during cell division

In a dividing cell, chromosomes interact with cellular scaffolding - called spindle microtubules - in order to move themselves to opposite ends of the cell, ensuring that both daughter cells receive an exact copy of their parent cell's genetic material.

1 Aug 2007