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UTHSC researchers awarded $1.9 million to study white matter mechanisms underlying dementia

The National Institute of Neurological Disorders and Stroke has awarded two UTHSC researchers over $1.9 million to study the pathogenesis of white matter damage, a main contributing factor to dementia.

3 Mar 2021

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

Neurodegenerative disorders such as Parkinson's and Alzheimer's disease are in the firing line after researchers identified an attractive therapeutic drug target.

3 Mar 2021

Researchers develop ultrapotent miniproteins that target SARS-CoV-2 receptor-binding domain

Researchers have investigated the effectiveness of a bioengineered miniprotein in protecting against SARS-CoV-2 infection in vivo. The researchers evaluated the miniprotein, LCB1, against SARS-CoV-2-mediated lung disease in human ACE2-expressing transgenic mice.

3 Mar 2021

Analytical Mass Spectrometry: How Did We Get Here, Where are We Going?

News-Medical interviews Rick Yost, winner of the Pittsburgh Analytical Chemistry Award 2021, about his research into mass spectrometry.

From Pittcon 3 Mar 2021

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

A new study by researchers at Mahidol University in Bangkok, Thailand, reports a COVID-19 vaccine candidate called HexaPro in producing neutralizing antibodies against the SARS-CoV-2 spike protein in an animal model.

3 Mar 2021

New instrument could obtain VCD spectrum of dipeptides

Currently, the roles of free D-amino acids and D-amino acid residues in proteins are garnering extensive attention in biological fields such as molecular biology, physiology, microbiology, and pathophysiology.

3 Mar 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Early antibody response predicts COVID-19 outcome

To address this gap, researchers from the U.S. evaluated the timing of antibody production against SARS-CoV-2 in hospitalized patients. They used a highly sensitive multiplexed bead-based immunoassay that allows for early detection of anti-SARS-CoV-2 antibodies. The study is published on the preprint server medRxiv.

2 Mar 2021

Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers

Researchers at the New York State Department of Health in the United States have said concerning mutations within the B.1.526 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently become prevalent in New York State warrant further monitoring.

2 Mar 2021

Study reveals how cells build 'mini-muscles' underneath their nucleus

Research groups at the University of Helsinki uncovered how motor protein myosin, which is responsible for contraction of skeletal muscles, functions also in non-muscle cells to build contractile structures at the inner face of the cell membrane.

2 Mar 2021

Novel drug for preventing Alzheimer's disease found to be safe and effective in animals

Researchers at the University of California San Diego School of Medicine and Massachusetts General Hospital have identified a new drug that could prevent Alzheimer's disease by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques in the brain.

2 Mar 2021

Sequential administration of immunotherapy and targeted therapy prolongs anti-tumor responses

Advanced melanoma is one of the deadliest types of cancer, with a 5-year survival rate of only 27% for patients with distant metastases.

2 Mar 2021

New nanoparticle-delivered COVID-19 vaccine candidate shows efficacy in ferret model

Researchers from Cleveland Clinic's Global Center for Pathogen Research & Human Health have developed a promising new COVID-19 vaccine candidate that utilizes nanotechnology and has shown strong efficacy in preclinical disease models.

2 Mar 2021

Researchers develop a genetic patch to prevent hereditary deafness

They can hear well up to about forty years old, but then suddenly deafness strikes people with DFNA9. The cells of the inner ear can no longer reverse the damage caused by a genetic defect in their DNA.

2 Mar 2021

New drug could prevent Alzheimer's by modulating key enzyme involved in amyloid plaque formation

Amyloid plaques are pathological hallmarks of Alzheimer's disease (AD) -- clumps of misfolded proteins that accumulate in the brain, disrupting and killing neurons and resulting in the progressive cognitive impairment that is characteristic of the widespread neurological disorder.

2 Mar 2021

Protein C News and Research

UTHSC researchers awarded $1.9 million to study white matter mechanisms underlying dementia

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

Researchers develop ultrapotent miniproteins that target SARS-CoV-2 receptor-binding domain

Analytical Mass Spectrometry: How Did We Get Here, Where are We Going?

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

New instrument could obtain VCD spectrum of dipeptides

How SARS-CoV-2 proteins affect vascular functionality

Early antibody response predicts COVID-19 outcome

Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers

Study reveals how cells build 'mini-muscles' underneath their nucleus

Novel drug for preventing Alzheimer's disease found to be safe and effective in animals

Sequential administration of immunotherapy and targeted therapy prolongs anti-tumor responses

New nanoparticle-delivered COVID-19 vaccine candidate shows efficacy in ferret model

Researchers develop a genetic patch to prevent hereditary deafness

New drug could prevent Alzheimer's by modulating key enzyme involved in amyloid plaque formation

Scientists reprogram a common bacterium to make designer sugar-based drug

Novel dual-targeting drug could become a next-generation treatment for EBV-related cancers

Could small synthetic antigen proteins be diagnostic tools for SARS-CoV-2?

Evonik partners with BioNTech to manufacture lipids for COVID-19 vaccine

SARS-CoV-2 UK variant shows low virulence and high shedding in hamster model

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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