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FDA designates Carbaglu for treatment of NAGS deficiency as a Fast Track product

The Food and Drug Administration (FDA) in the USA has concluded that Carbaglu (carglumic acid) for treatment of N-acetylglutamate synthase (NAGS) deficiency meets the criteria for fast track designation.

10 Jul 2007

More muscle for the argument to give up smoking

Researchers at The University of Nottingham have got more bad news for smokers. Not only does it cause cancer, heart attacks and strokes but smokers will also lose more muscle mass in old age than a non-smoker. The effect of this predisposes smokers to an accelerated decline in physical function and loss of independence.

9 Jul 2007

Potential new treatment pathway for Parkinson's

In the vast majority of Parkinson's disease (PD) patients, the disorder arises not because of a genetic defect, but because some external insult triggers the death of dopamine-producing neurons.

9 Jul 2007

University Jaume I patents fluorescent sensor

The University Jaume I (UJI) has patented a new fluorescent chemical sensor that is capable of detecting citric acid at low concentrations more rapidly and cheaply than the current optical sensors.

9 Jul 2007

Olive-pomace oil slows down AIDS

Olive oil has become part of the fight against the Human Immunodeficiency Virus (HIV) - the cause of AIDS - thanks to the research carried out by the Bionat team, from the University of Granada, headed by Prof. Andres Garcia-Granados, senior lecturer in Organic Chemistry.

9 Jul 2007

New ulcerative colitis gene found

Researchers at The Hospital for Sick Children (SickKids), Mount Sinai Hospital and the University of Pittsburgh have identified a previously unsuspected gene found to be associated with ulcerative colitis.

9 Jul 2007

Discovery of enzyme critical in DNA replication

In this week's issue of Science, researchers from the National Institute of Environmental Health Sciences (NIEHS) and Umea University in Sweden report an important discovery about a critical new role that an enzyme called DNA polymerase epsilon plays in replicating DNA in higher organisms such as yeast and perhaps even humans.

9 Jul 2007

Abiraterone reduces levels of prostate specific antigen

For prostate cancer patients whose tumors have continued to grow despite medical or surgical castration, a new drug candidate that inhibits production of male hormones anywhere in the body is showing promise in early trials.

9 Jul 2007

Orlistat weight loss drug points to new cancer treatments

Based on their surprising discovery that an obesity drug can kill cancer cells, scientists at Wake Forest University School of Medicine have made a new finding about the drug's effects and are working to design more potent cancer treatments.

9 Jul 2007

Rimonabant may prevent and treat obesity-related liver disease

A new study on the effect of the anti-obesity drug rimonabant on liver function in obese rats found that it reduced markers of liver damage, decreased levels of pro-inflammatory proteins, and improved lipid profiles.

4 Jul 2007

Genetic mutation that may alter response to cancer therapeutics found

Researchers from Eli Lilly & Company and the Phoenix-based Translational Genomics Research Institute (TGen) today announced finding a novel recurring mutation of the gene AKT1 in breast, colorectal and ovarian cancers.

4 Jul 2007

RNA molecules can orchestrate gene activity across vast portions of the human genome

Large, seemingly useless pieces of RNA - a molecule originally considered only a lowly messenger for DNA - play an important role in letting cells know where they are in the body and what they are supposed to become, researchers at Stanford University School of Medicine have discovered.

29 Jun 2007

New type of drug shows promise for chronic lymphocytic leukemia

A new type of engineered drug candidate has shown promise in treating chronic lymphocytic leukemia in both test tube and early animal tests, a new study shows.

29 Jun 2007

Key finding on ALS related protein

Chemists from UCLA and the University of Florence in Italy may have solved an important mystery about a protein that plays a key role in a particular form of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, a progressive, fatal neurodegenerative disorder that strikes without warning.

28 Jun 2007

Scientists discover role of ataxia telangiectasia mutated protein in DNA repair

Scientists from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Cancer Institute (NCI), and Integrative Bioinformatics Inc. have made an important discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the body's ability to repair damaged DNA.

28 Jun 2007

Scientists create sheets of protein-gold arrays

In groundbreaking research, scientists have demonstrated the ability to strategically attach gold nanoparticles -- particles on the order of billionths of a meter -- to proteins so as to form sheets of protein-gold arrays.

28 Jun 2007

CARS microscopy reveals clues to myelin damage

Researchers have discovered that calcium ions could play a crucial role in multiple sclerosis by activating enzymes that degrade the fatty sheath that insulates nerve fibers.

28 Jun 2007

Gene variant increases risk for alcoholism following childhood abuse

Girls who suffered childhood sexual abuse are more likely to develop alcoholism later in life if they possess a particular variant of a gene involved in the body's response to stress, according to a new study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH).

27 Jun 2007

Amphinase molecule from frog could provide first drug treatment for brain tumours

A synthetic version of a molecule found in the egg cells of the Northern Leopard frog (Rana pipiens) could provide the world with the first drug treatment for brain tumours.

27 Jun 2007