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3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Children with aggressive blood cancers have differences -- not just in the DNA code of their blood cells -- but also in the heavily twisted protein superstructure that controls access to genes.

23 Mar 2020

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

A study found that children with aggressive blood cancers have different superstructures of the proteins that control gene access.

23 Mar 2020

Study sheds light on myelin's role in 'chemobrain' and multiple sclerosis

Scientists have discovered that myelin is not as metabolically inert as has previously been thought.

23 Mar 2020

Stem cells establish contacts with nerves in tissue regeneration and cancer progression

Researchers at the University of Zurich show that different stem cell populations are innervated in distinct ways.

23 Mar 2020

Tiny device can rapidly detect harmful bacteria in blood

Engineers have created a tiny device that can rapidly detect harmful bacteria in blood, allowing health care professionals to pinpoint the cause of potentially deadly infections and fight them with drugs.

23 Mar 2020

Research may help older adults maintain skeletal muscle mass and physical function for longer

Drug therapies that help older adults maintain their skeletal muscle mass and physical function for longer could be a step closer after researchers at the University of Birmingham identify a key mechanism that drives the clearance of damaged mitochondria.

22 Mar 2020

Newly discovered molecule in the lymphatic system could play a role in autoimmune diseases

A study by investigators at Hospital for Special Surgery has discovered a molecule in the lymphatic system that has the potential to play a role in autoimmune disease.

22 Mar 2020

Researchers invent new method to map sugar structures of blood-thinning drug

The blood-thinning drug heparin is used all over the world. But, the underlying sugar structures of heparin and the wider family of heparan sulfate sugars in cells have not been fully mapped.

22 Mar 2020

New drug can alleviate the side effects of tricyclic antidepressants

About one in five Danes are affected by depression at some point in their lives. The severe depressions may be treated with the so-called 'tricyclic antidepressants', an antidepressant drug that is more effective than the drugs used for mild and moderate depressions.

22 Mar 2020

Lab-on-chip device to monitor how extracellular matrix responds to disease

Similarly to how a picked lock gives away that someone has broken into a building, the stiffening of a structure surrounding cells in the human body can indicate that cancer is invading other tissue.

21 Mar 2020

Antibiotic blocks the integration of building blocks into the cell wall of pathogens

One of the last arrows in the quiver in the fight against dangerous bacteria is the reserve antibiotic daptomycin.

21 Mar 2020

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors.

21 Mar 2020

Researchers decode 3D architecture of SARS-CoV-2 main protease

Teams around the world are working hard to develop active substances against SARS-CoV-2. The structural analysis of functional proteins of the virus is very helpful for this goal. The function of a protein is closely related to its 3D architecture.

21 Mar 2020

Older cancer patients taking multiple medications are at higher risk of hospitalization

As adults age, they accumulate a number of medications for chronic conditions. Older patients take anywhere between 5-15 medications per year, which increases the risk that some of the drugs will counteract each other.

21 Mar 2020

Mask shortage straps pharmacists who need them to keep medicines pure

Pharmacy staff who prepare IV drugs inside hospitals are the latest health care workers decrying a shortage of masks as they scramble to prepare medications for patients with everything from cancer to COVID-19.

20 Mar 2020

Organ-Chips provide human-relevant insights into diseases and toxicity mechanisms

Organs-on-Chips technology has entered the mainstream and has reached 150 installations for use by researchers across many industries, including 10 of the top 25 biopharmaceutical companies, as well as leading international academic research centers and U.S. government laboratories, including the U.S. FDA through a collaborative agreement and the U.S. Army.

20 Mar 2020

CARB-X awards $2.86M to develop novel oral antibiotic to treat drug-resistant gonorrhea

Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.

20 Mar 2020

Drugs News and Research

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

Study sheds light on myelin's role in 'chemobrain' and multiple sclerosis

Stem cells establish contacts with nerves in tissue regeneration and cancer progression

Tiny device can rapidly detect harmful bacteria in blood

Research may help older adults maintain skeletal muscle mass and physical function for longer

Newly discovered molecule in the lymphatic system could play a role in autoimmune diseases

Researchers invent new method to map sugar structures of blood-thinning drug

New drug can alleviate the side effects of tricyclic antidepressants

Lab-on-chip device to monitor how extracellular matrix responds to disease

Antibiotic blocks the integration of building blocks into the cell wall of pathogens

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Researchers decode 3D architecture of SARS-CoV-2 main protease

Older cancer patients taking multiple medications are at higher risk of hospitalization

Mask shortage straps pharmacists who need them to keep medicines pure

Organ-Chips provide human-relevant insights into diseases and toxicity mechanisms

CARB-X awards $2.86M to develop novel oral antibiotic to treat drug-resistant gonorrhea

UC researchers identify populations most at risk of overdosing on opiates

Researchers highlight urgent need for public health leadership during COVID-19 pandemic

How Ritalin works: focus on benefits rather than costs of work

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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