Preclinical News and Research

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Gene editing silences mutant microRNA, restores hearing in adult mice

Researchers have used gene editing to restore hearing in adult mice with a type of inherited hearing loss. They showed that shutting down a damaged copy of a gene called a microRNA (miRNA) enabled the animals to regain hearing. The approach by a research team supported by the National Institutes of Health (NIH), reported in Science Translational Medicine, may eventually lead to potential treatments for inherited hearing loss in people.

13 Jul 2024

Groundbreaking mRNA vaccine administered to captive elephant to fight EEHV

Colossal, the de-extinction company, announces that the mRNA vaccine it helped to provide research support and acceleration funding for has been administered to the first elephant in captivity.

13 Jul 2024

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy treatments.

11 Jul 2024

Existing drug shows promise for treating common liver disease

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people. The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidaemia, a common condition in diabetics. Now, however, it could help address this serious liver disease, which still has no specific treatment.

11 Jul 2024

New gene editing technique offers hope for millions

A team led by Mass Eye and Ear researchers has demonstrated for the first time a successful restoration of hearing through a novel, in vivo genome editing approach in an adult mouse model with a form of inherited deafness caused by mutations in microRNA.

11 Jul 2024

Novel molecule could inform new therapies for stroke-related brain injury

A newly developed molecule, LK-2, could inform new therapies for stroke-related brain injury, finds scientists at The Hospital for Sick Children (SickKids).

10 Jul 2024

New consortium receives NIH grant to accelerate development of effective TB treatments

A new consortium co-led by Weill Cornell Medicine, has been awarded a five-year, $31 million grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases to accelerate the development of faster, more effective treatment regimens for tuberculosis (TB).

10 Jul 2024

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

10 Jul 2024

Stem-like cells found to drive growth of aggressive pediatric brain tumors

A team of researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma (Gr3-MB) in the developing brain.

9 Jul 2024

Newcells Biotech appoints Emile Shaffu as Director of Sales

Newcells Biotech, a leading drug discovery partner specializing in developing in vitro models and bespoke assay services to improve the prediction of in vivo human outcomes, today announced the appointment of Emile Shaffu as Director of Sales.

From Newcells Biotech 9 Jul 2024

Case Western Reserve University receives $1.5M grant for oral drug trial to prevent blindness in RP patients

There's only one U.S. Food and Drug Administration-approved therapy for an inherited retinal disease, and dozens of retinitis pigmentosa (RP) genes for which no therapy is available.

8 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Researchers found that KLF15 is crucial for maintaining white adipocyte properties in subcutaneous fat, and its deletion induces beige adipocyte characteristics, suggesting new obesity treatment pathways.

4 Jul 2024

Impaired communication between immune cells leads to cognitive impairment in female Alzheimer's patients

Lead author Neta Rosenzweig, PhD, of the Ann Romney Center for Neurological Diseases, and senior author Oleg Butovsky, PhD, of the Ann Romney Center and Gene Lay Institute of Immunology and Inflammation, share key messages from their paper "Sex-Dependent APOE4 Neutrophil-Microglia Interactions Drive Cognitive Impairment in Alzheimer's Disease" published in Nature Medicine.

3 Jul 2024

Exercise boosts tumor-killing white blood cells in breast cancer patients

A new Finnish study from University of Turku shows that already a 30-minute exercise can increase the proportion of tumor-killing white blood cells in the bloodstream of breast cancer patients.

3 Jul 2024

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

A major challenge in developing a vaccine for HIV is that the virus mutates fast - very fast. Although a person initially becomes infected with one or a few HIV strains, the virus replicates and mutates quickly, resulting in a "swarm" of viral strains existing in a single body.

2 Jul 2024

Preclinical News and Research

Gene editing silences mutant microRNA, restores hearing in adult mice

Groundbreaking mRNA vaccine administered to captive elephant to fight EEHV

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

Existing drug shows promise for treating common liver disease

New gene editing technique offers hope for millions

Novel molecule could inform new therapies for stroke-related brain injury

New consortium receives NIH grant to accelerate development of effective TB treatments

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

Stem-like cells found to drive growth of aggressive pediatric brain tumors

Newcells Biotech appoints Emile Shaffu as Director of Sales

Case Western Reserve University receives $1.5M grant for oral drug trial to prevent blindness in RP patients

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Impaired communication between immune cells leads to cognitive impairment in female Alzheimer's patients

Exercise boosts tumor-killing white blood cells in breast cancer patients

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

SRI’s novel injectable formulation aims to provide a better option to fight malaria

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

NIAID scientists discover probiotic treatment for eczema

Nonhuman primate model reveals early-stage Alzheimer’s disease progression

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