Protein C News and Research

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CU Boulder research offers clues to why psychiatric drugs help only some people

New CU Boulder research, published in the journal eLIfe, sheds light on one reason those individual differences may exist. Turns out a key protein in the brain called AKT may function differently in males than females.

1 Feb 2021

Life-threatening genetic immunodeficiency reversed by a rare DNA change

Researchers have revealed how a rare DNA change rebalanced the immune system of patients with a life-threatening genetic immunodeficiency.

1 Feb 2021

Study uncovers new anti-inflammatory role for blood clot protein fibrinogen

Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases.

1 Feb 2021

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

A new study by researchers in China and the U.S. describes a round-up of the effects of commonly used hypoglycemic drugs on the outcomes of COVID-19 in diabetic patients.

1 Feb 2021

New platform for detecting and monitoring SARS-CoV-2 antibody responses

Researchers in the U.S. have released a new study that describes a powerful but inexpensive tool designed to detect and monitor specific antibodies to SARS-CoV-2 over time.

1 Feb 2021

Colchicine may have therapeutic potential against COVID-19

A new study describes the results of colchicine in mitigating the inflammatory storm associated with COVID-19, and thus preventing a percentage of severe and critical cases.

1 Feb 2021

Food guidelines change but fail to take cultures into account

The U.S. Department of Agriculture and the Department of Health and Human Services have once again developed new food guidelines for Americans that urge people to customize a diet of nutrient-dense food. For the first time, they make recommendations for infant nutrition and for different stages of life.

1 Feb 2021

Enriched diet and companionship can reduce pain in mice with sickle cell disease

Researchers from the University of California, Irvine and the University of Minnesota have found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin.

1 Feb 2021

Protein alteration contributes to degeneration of neuronal populations in Huntington's disease

Protein alteration in the family of lamins causes several diseases, known as laminopathies, such as progeria or precocious aging.

1 Feb 2021

Adding mushrooms to diet increases the intake of micronutrients

Researchers have identified another good reason to eat more mushrooms. New research , published in Food Science & Nutrition (January 2021) found that adding a mushroom serving to the diet increased the intake of several micronutrients, including shortfall nutrients such as vitamin D, without any increase in calories, sodium or fat.

1 Feb 2021

Inhaled single dose vaccine creates antibodies and prevents infection in rhesus macaques

Now, a new preprint research paper describes a chimpanzee adenovirus-vectored vaccine that, when administered intranasally in rhesus macaques, led to a robust immune response and demonstrated protection against infection by the virus that causes COVID-19, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The preprint is published on the bioRxiv server.

1 Feb 2021

E484K mutation is potentially associated with SARS-CoV-2 adaptive fitness

A team of Brazilian scientists has recently conducted genomic and phylogenetic analyses of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome to understand the viral evolution process better. Their analyses reveal that the E484K mutated variant of SARS-CoV-2 is present in three different lineages in four Brazilian regions and that the mutation may serve as a common solution for viral evolution.

31 Jan 2021

Study: Link between protein folding and misfolding can lead to the formation of amyloid fibers

Researchers from Osaka University have described the link between accurate protein folding and misfolding that can lead to the formation of amyloid fibers, which are implicated in neurodegenerative diseases

31 Jan 2021

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

Researchers at National Taiwan University Hospital in Taipei have conducted a study demonstrating the potential effectiveness of a novel drug combination at reducing morbidity and mortality in coronavirus disease 2019 (COVID-19).

31 Jan 2021

Crystal structures of nanobodies could aid the design of COVID-19 therapies

Researchers at the National Institutes of Health in Bethesda, Maryland, have shown how certain synthetic nanobodies bind to the agent that causes coronavirus disease 2019 (COVID-19) – a development that could help inform the design of therapies.

31 Jan 2021

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that the independent Data Safety Monitoring Board (DSMB) for the global Phase 2/3 study of opaganib in patients with severe COVID-19, unanimously recommended to continue the study following a pre-scheduled futility review of unblinded efficacy data from the first 135 patients treated in the study and safety data from the first 175 patients.

30 Jan 2021

Researchers uncover the physics behind formation of branching microtubules during cell division

As any cook knows, some liquids mix well with each other, but others do not. For example, when a tablespoon of vinegar is poured into water, a brief stir suffices to thoroughly combine the two liquids.

30 Jan 2021

Study unravels relationship status of important receptor on immune and cancer cells

An important receptor on the surface of cancer and immune cells prefers to remain noncommittal; sometimes it is present as a single, sometimes as a pair. This was first shown by an MDC team in the journal PNAS, and will decisively advance the development of new medications.

30 Jan 2021

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells.

29 Jan 2021

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies.

29 Jan 2021

Protein C News and Research

CU Boulder research offers clues to why psychiatric drugs help only some people

Life-threatening genetic immunodeficiency reversed by a rare DNA change

Study uncovers new anti-inflammatory role for blood clot protein fibrinogen

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

New platform for detecting and monitoring SARS-CoV-2 antibody responses

Colchicine may have therapeutic potential against COVID-19

Food guidelines change but fail to take cultures into account

Enriched diet and companionship can reduce pain in mice with sickle cell disease

Protein alteration contributes to degeneration of neuronal populations in Huntington's disease

Adding mushrooms to diet increases the intake of micronutrients

Inhaled single dose vaccine creates antibodies and prevents infection in rhesus macaques

E484K mutation is potentially associated with SARS-CoV-2 adaptive fitness

Study: Link between protein folding and misfolding can lead to the formation of amyloid fibers

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

Crystal structures of nanobodies could aid the design of COVID-19 therapies

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

Researchers uncover the physics behind formation of branching microtubules during cell division

Study unravels relationship status of important receptor on immune and cancer cells

Discovery offers novel possibilities to target drug-resistant HER2-positive cancers

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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