Efficacy News and Research

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Using radiation models to improve cancer therapies: an interview with Adrian Treverton, COO of Xstrahl and Jean-Pierre Wery, President of Crown Bioscience

What we are trying to do is take a cancer model like the PDX model (patient-derived tumor xenograft), which is a human-derived cancer growing in an in vivo model and apply radiation to that model.

From Xstrahl 20 Nov 2013

BioCardia reports positive results for Transendocardial Autologous Cells in Ischemic Heart Failure Trial

BioCardia, Inc., a leader in cardiovascular regenerative medicine, today announced positive 12-month results for the randomized Transendocardial Autologous Cells (MSC or BMC) in Ischemic Heart Failure Trial (TAC-HFT).

20 Nov 2013

Gene-based method for selecting doses of warfarin no better than standardized dosing methods

A new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania has determined that a gene-based method for selecting patients' doses of the popular heart medication warfarin is no better than standardized dosing methods. The study was presented today at the 2013 Scientific Sessions of the American Heart Association and published simultaneously in the New England Journal of Medicine.

20 Nov 2013

Tasquinimod drug effective for men with metastatic castration-resistant prostate cancer

An investigational prostate cancer treatment slows the disease's progression and may increase survival, especially among men whose cancer has spread to the bones, according an analysis led by the Duke Cancer Institute.

20 Nov 2013

First patients enrolled in EF-21 Study of NovoTTF Therapy for brain metastases from NSCLC cancer

Novocure announced today that the first patients have enrolled in the EF-21 Study, a prospective randomized clinical study of NovoTTF Therapy for patients with brain metastases from non-small cell lung carcinoma cancer. NovoTTF Therapy is an anti-mitotic treatment delivered continuously throughout the day by the NovoTTF-100A System.

20 Nov 2013

Once-daily edoxaban prevents stroke in patients with atrial fibrillation

According to the United States Centers for Disease Control and Prevention, over 800,000 Americans die each year from heart disease and stroke. Stroke is the leading cause of serious long-term disability and death in the US. In addition to lifestyle changes, medications such as anti-blood clotting drugs are helpful in the prevention of stroke.

20 Nov 2013

Brain signals in fibromyalgia patients: an interview with Dr. Marco Loggia from Massachusetts General Hospital and Harvard Medical School in Boston

Fibromyalgia patients suffer from a variety of symptoms, including widespread body pain and myofascial tenderness. They are ‘hyperalgesic’, which means that if you give them a stimulus that in healthy subjects is just mildly painful (or even completely innocuous), they may perceive it as excruciatingly painful.

19 Nov 2013

Heart failure patients receiving LVAD may benefit from injection of powerful cells directly into heart

A multicenter team of researchers within the NIH-funded Cardiothoracic Surgical Trials Network, led by Icahn School of Medicine at Mount Sinai, have found end-stage heart failure patients who receive a surgically implanted left ventricular assist device heart pump may also benefit from a single dose of millions of powerful cells injected directly into their heart during surgery.

19 Nov 2013

Researchers study safety of transendocardial stem cell injection in patients with ischemic cardiomyopathy

Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial stem cell injection with autologous mesenchymal stem cells and bone marrow mononuclear cells in patients with ischemic cardiomyopathy.

19 Nov 2013

KLOX receives CE mark approval in Europe for non-invasive acne vulgaris treatment

KLOX Technologies Inc. is pleased to announce that it has received CE mark approval in Europe for its topical photo-converter gel as a Class IIa Medical Device for the treatment of acne vulgaris, including all severities. The gel is part of KLOX's LumiCleanse System, a first-in-class innovative, non-invasive acne vulgaris treatment with a clinically-proven superior safety and efficacy profile. The LumiCleanseTM System was previously approved for the treatment of all severities of acne vulgaris in Canada in September of this year.

19 Nov 2013

Boston Scientific gets CE Mark approval for Vercise Deep Brain Stimulation System

The Boston Scientific Corporation Vercise Deep Brain Stimulation System has received CE Mark approval for the treatment of intractable primary and secondary dystonia, a neurological movement disorder characterized by involuntary muscle contractions.

19 Nov 2013

Study: Use of bone marrow mononuclear stem cells does not improve heart function

New data reported by the Cardiovascular Cell Therapy Research Network (CCTRN) at the 2013 Scientific Sessions of the American Heart Association in Dallas showed that the use of bone marrow mononuclear stem cells (BMCs) did not improve heart function significantly more at one year than at six months.

19 Nov 2013

Women & Infants gets $3M grant to identify infants at greatest risk for developmental impairment

Advances in technology and medical care have dramatically improved survival for infants born prior to 30 weeks gestation and weighing less than three pounds. However, up to 50 percent of these infants may develop physical, cognitive, language and/or behavioral impairments that require extensive health care, educational and psychosocial community resources through adulthood. At this time, there is no reliable method to identify those infants who will go on to develop impairments and those who will not.

19 Nov 2013

Extract from bitter melon may have therapeutic qualities to treat head and neck cancer

Extract taken from an Asian vegetable may have therapeutic qualities to treat head and neck cancer, a Saint Louis University researcher has found.

19 Nov 2013

Generex Biotechnology provides update on Phase II trial of AE37 breast cancer vaccine

Generex Biotechnology Corporation today announced that it has reached a pre-specified point in the ongoing Phase II trial of its AE37 breast cancer vaccine to initiate its primary efficacy analysis. The drug is a novel immunotherapeutic cancer vaccine being developed by the Company's wholly-owned subsidiary, Antigen Express, Inc. A previously released positive interim analysis showed a strong trend toward reduced relapse in breast cancer patients receiving the AE37 vaccine.

18 Nov 2013

Kiadis reports successful Phase II enrollment for CR-AIR-007 ATIR blood cancer treatment study

Kiadis Pharma B.V., a clinical stage biopharmaceutical company developing treatments for blood cancers, today announces the successful Phase II enrollment of approximately ten patients of whom the majority have already been transplanted and received ATIR™. Kiadis Pharma's lead program, ATIR™, is a cell-based product designed to enable stem cell transplantations from partially mismatched (haploidentical) family donors for blood cancer patients who do not have a standard of care stem cell donor available. Topline data from the trial (CR-AIR-007) is expected in the first half of 2014.

18 Nov 2013

New hope for patients whose melanoma has metastasised to the brain

New data show that in patients whose melanoma (BRAF V600 mutation-positive) has spread (metastasised) to the brain, Zelboraf (vemurafenib) extends life expectancy by over six months compared to chemotherapy.1 These results are welcome news for patients suffering from metastatic melanoma, as up to half of these patients are diagnosed with brain metastases with many given less than six months to live.1

18 Nov 2013

Treatment of pelvic nodes can be easily integrated into IMRT-based treatment strategy

Treatment of pelvic nodes individualized by inclusion of sentinel nodes can be easily integrated into an IMRT-based treatment strategy, according to the new study conducted by a group of researchers from T-bingen and Munich in Germany. The target volume concept seems to correctly cover individual pelvic nodes, which is indicated by the absence of any nodal recurrence within five years of follow-up.

18 Nov 2013

Oraya presents data from INTREPID study of stereotactic radiotherapy for treatment of wet AMD

Oraya® Therapeutics, Inc. announced today that initial three-year safety follow-up data from its INTREPID study of Oraya Therapy™ stereotactic radiotherapy for the treatment of wet age-related macular degeneration (AMD) were presented for the first time today during the America Academy of Ophthalmology's (AAO) annual meeting in New Orleans.

16 Nov 2013

GO drug may improve outcome of bone marrow transplantation for select pediatric leukemia patients

Combining the drug gemtuzumab ozogamicin with conventional chemotherapy may improve the outcome of bone marrow transplantation for some children battling high-risk acute myeloid leukemia, according to a study led by St. Jude Children's Research Hospital. The results appear in the current edition of the journal Cancer.

16 Nov 2013

Efficacy News and Research

Using radiation models to improve cancer therapies: an interview with Adrian Treverton, COO of Xstrahl and Jean-Pierre Wery, President of Crown Bioscience

BioCardia reports positive results for Transendocardial Autologous Cells in Ischemic Heart Failure Trial

Gene-based method for selecting doses of warfarin no better than standardized dosing methods

Tasquinimod drug effective for men with metastatic castration-resistant prostate cancer

First patients enrolled in EF-21 Study of NovoTTF Therapy for brain metastases from NSCLC cancer

Once-daily edoxaban prevents stroke in patients with atrial fibrillation

Brain signals in fibromyalgia patients: an interview with Dr. Marco Loggia from Massachusetts General Hospital and Harvard Medical School in Boston

Heart failure patients receiving LVAD may benefit from injection of powerful cells directly into heart

Researchers study safety of transendocardial stem cell injection in patients with ischemic cardiomyopathy

KLOX receives CE mark approval in Europe for non-invasive acne vulgaris treatment

Boston Scientific gets CE Mark approval for Vercise Deep Brain Stimulation System

Study: Use of bone marrow mononuclear stem cells does not improve heart function

Women & Infants gets $3M grant to identify infants at greatest risk for developmental impairment

Extract from bitter melon may have therapeutic qualities to treat head and neck cancer

Generex Biotechnology provides update on Phase II trial of AE37 breast cancer vaccine

Kiadis reports successful Phase II enrollment for CR-AIR-007 ATIR blood cancer treatment study

New hope for patients whose melanoma has metastasised to the brain

Treatment of pelvic nodes can be easily integrated into IMRT-based treatment strategy

Oraya presents data from INTREPID study of stereotactic radiotherapy for treatment of wet AMD

GO drug may improve outcome of bone marrow transplantation for select pediatric leukemia patients

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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