Antidepressant News and Research

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Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They can improve your mood, sleep, appetite and concentration. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try several before finding what works best for you.

Uncovering the neurobiological mechanisms of delta opioid receptor agonists

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use. This underscores the urgent need for novel, rapidly-acting therapeutic agents with minimal side effects.

15 Jan 2025

Maternal medications linked to changes in protein and fat levels in human milk

The impact of maternal antidepressant and anti-inflammatory use on breast milk composition shows reduced protein and fat levels, affecting infant nutrition.

9 Jan 2025

Do GLP-1 receptor agonists increase the risk of suicide in patients?

A nationwide study confirms GLP-1 RAs pose no short-term psychiatric risk, showing a negative association with suicidal behaviors in high-risk populations.

6 Jan 2025

Chemogenetic activation reveals male-female differences in stress resistance neural circuits

Subtle activation of a small subset of neurons in one region of the brain can make male mice resilient to, and even reverse, the detrimental effects of chronic stress. The same is true for female mice, but in a totally different region of the brain.

19 Dec 2024

Zebrafish study uncovers how ketamine affects brain cells to treat depression

The decades-old anesthetic ketamine could be a game changer for treating severe depression, but there are still many questions about how the drug works, including exactly how it affects the brain's cells and circuits.

17 Dec 2024

Gut-targeted antidepressants: A novel approach to battling depression and anxiety

Most of us have experienced the effects of moods and emotions on our gastrointestinal tract, from "butterflies" in the stomach caused by nervousness to a loss of appetite when we're feeling blue.

11 Dec 2024

Antidepressant use linked to persistent genital sensitivity loss

The use of antidepressants is associated with sexual side effects including reduced genital sensitivity that persists after stopping the medication, a new Simon Fraser University study finds.

6 Dec 2024

Brain signature of resilience suggests a new way to recovery from trauma

Researchers at UCSF find a brain signature of resilience in mice that suggests a new way of treating severe depression.

4 Dec 2024

CBT and rehabilitation likely to improve long covid symptoms

Cognitive behavioral therapy (CBT) and a program of physical and mental rehabilitation probably improve symptoms of long covid, but the effects are modest, finds a review of the latest evidence published by The BMJ today.

27 Nov 2024

Study provides insight into how low-dose ketamine alleviates symptoms of major depression

University at Buffalo neuroscientists have identified the binding site of low-dose ketamine, providing critical insight into how the medication, often described as a wonder drug, alleviates symptoms of major depression in as little as a few hours with effects lasting for several days.

19 Nov 2024

New discovery reveals NMDAR's critical function in maintaining brain stability

Researchers at Tel Aviv University have made a fundamental discovery: the NMDA receptor (NMDAR) - long studied primarily for its role in learning and memory - also plays a crucial role in stabilizing brain activity.

15 Nov 2024

Study identifies key priorities for research on reducing psychiatric medication

Study hopes to inform the research agenda and help future research to focus on the questions that are most important to key stakeholders.

12 Nov 2024

Research highlights immune system's role in depression

A new study highlights the link between inflammation and depression, challenging traditional neurotransmitter-focused theories.

11 Nov 2024

Brain-stimulation therapy at home reduces major depression symptoms

This study highlights the efficacy of home-based tDCS in treating major depressive disorder, with significant improvements in depressive symptoms and remission.

22 Oct 2024

Scientists discover gut microbiome differences in children with autism

Researchers found differences in gut bacteria between children with autism and typically developing children but caution that more research is needed to clarify these associations and their therapeutic potential.

20 Oct 2024

Innovative approach by Waymark enhances health outcomes for Medicaid patients

Waymark, a public benefit company dedicated to improving access and quality of care in Medicaid, today published a peer-reviewed study in the New England Journal of Medicine (NEJM) Catalyst evaluating the impact of its early intervention model in its first year of service.

18 Oct 2024

Rising concerns over benzodiazepine prescriptions in older stroke survivors

Although there has been a slight downward trend in the prescription of benzodiazepines (depressants that relieve anxiety, muscle spasms, produce sedation and reduce seizures) among older adults over the last decade, the rate of first-time prescriptions for these medications after an ischemic (clot-caused) stroke is still sizable, according to research published today in Stroke, the peer-reviewed scientific journal of the American Stroke Association, a division of the American Heart Association.

17 Oct 2024

Safe storage crucial to prevent child drug poisoning

New data shows that the number of children suffering a seizure after swallowing medications or illegal substances has doubled between 2009 and 2023 in the US. The findings were presented today (Wednesday) at the European Emergency Medicine Congress.

16 Oct 2024

Liver X receptor beta offers new hope in treating depression and anxiety

Liver X receptor beta (LXRβ) shows potential in reducing depression and anxiety by improving neurogenesis, reducing neuroinflammation, and enhancing cognitive and emotional function. More research on LXR agonists could reveal new treatments for mental health disorders.

8 Oct 2024

Study reveals sponsorship bias in psychiatric drug trials

Psychiatric drugs are reported to be about 50% more effective in clinical trials funded by the drug's manufacturer than when trials of the same drug are sponsored by other groups, new research shows.

7 Oct 2024