Glioblastoma News and Research

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Glioblastoma is the most aggressive and malignant form of glioma, a type of primary brain cancer. Surgery is often used to treat gliomas, along with radiation. However, since surgery and radiation fail to cure the disease, doctors may turn to additional radiation or chemotherapy. In early stages glioblastoma tumors often grow without symptoms and therefore can become quite large before symptoms arise. When the tumor becomes symptomatic, tumor growth is usually very rapid and is accompanied by altered brain function, and if left untreated the disease becomes lethal. Although primary treatment is often successful in temporarily stopping the progression of the tumor, glioblastomas almost always recur and become lethal.

Chimeric RNA offers new clues for tailoring prostate cancer therapies

Prostate cancer has distinct genetic properties in different groups of men that can be targeted to improve patient outcomes, UVA Cancer Center researchers have discovered.

24 Apr 2025

New study sheds light on 3D gene hubs driving brain cancer

The way DNA folds inside the nucleus of brain cells may hold the key to understanding a devastating form of brain cancer called glioblastoma, suggests a new preclinical study from Weill Cornell Medicine researchers.

22 Apr 2025

Targeting PGM3 offers new hope against deadly brain tumor

Researchers have found that targeting an enzyme called PGM3 can help stop the growth of glioblastoma, the most dangerous type of brain tumor.

18 Apr 2025

Inherited mutations in healthy cells may contribute to cancer development

Most cancer genome studies have focused on mutations in the tumor itself and how such gene variants allow a tumor to grow unchecked.

15 Apr 2025

Triple therapy reduces tumor burden and improves survival in glioblastoma models

A new research paper was published in Oncotarget, Volume 16, on March 27, 2025, titled "Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT."

4 Apr 2025

Breakthrough in scalable nanoparticle manufacturing for cancer treatment

Polymer-coated nanoparticles loaded with therapeutic drugs show significant promise for cancer treatment, including ovarian cancer.

4 Apr 2025

EchoBack CAR T-cells could be a game changer in cancer immunotherapy

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without tiring.

2 Apr 2025

New insights into how disruption of calcium transport leads to autism and intellectual disability

A new study by McGill University researchers yields insights into how the disruption of calcium transport in the brain is linked to autism and intellectual disability.

2 Apr 2025

Yale study unlocks potential of lupus-related antibody to target cold tumors

Yale scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into "cold" tumors and flip on an immune response that has been turned off by cancer.

25 Mar 2025

New research reveals potential path forward for glioblastoma treatment

Glioblastoma has remained one of the toughest cancers to treat, resisting even the latest advances in immunotherapy.

17 Mar 2025

Study highlights the role of ELF4 as a key transcription factor in development, immunity, and oncology

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review underscores its molecular complexity and clinical significance, shedding light on its dual role in tumor suppression and oncogenesis.

11 Mar 2025

Study links firefighting chemicals to increased glioma risk

A new study uncovered an association between exposure to chemicals commonly used in firefighting and glioma risk, reinforcing earlier research that has suggested a link between firefighting and the development of cancers.

10 Mar 2025

Circular RNA plays key role in cancer biology and therapy

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

8 Mar 2025

EZH2 inhibition offers hope for fighting treatment-resistant cancers

The critical role of EZH2, an essential epigenetic regulator, in cancer progression and treatment is underscored in this new review article published in Genes & Diseases.

8 Mar 2025

Breakthrough drug more than doubles survival in glioblastoma patients

A drug developed at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has been shown to extend survival for patients with glioblastoma, the most common primary brain tumor in adults.

7 Mar 2025

Exploring the role of subventricular zone in neural regeneration, neurodegenerative diseases

This recently published exploration into the subventricular zone (SVZ) highlights its critical role in neural regeneration, neurodegenerative diseases, and glioblastoma multiforme (GBM).

5 Mar 2025

Engineered TIMPs show promise in fighting glioblastoma invasion

A new research paper was published in Oncotarget, Volume 16, on February 28, 2025, titled "Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells."

3 Mar 2025

Researchers uncover how brain tumors reprogram neutrophils to hinder cancer treatment

The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth.

2 Mar 2025

UCLA scientists discover new approach for treating glioblastoma

UCLA scientists have identified a potential new strategy for treating glioblastoma, the deadliest form of brain cancer, by reprogramming aggressive cancer cells into harmless ones.

26 Feb 2025