Histopathology News and Research

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Favipiravir has weak effect on SARS-CoV-2 and Hydroxychloroquine none at all in hamster model

A new study from Belgian researchers shows that antiviral drug Favipiravir could have a weak effect against the dreaded novel coronavirus or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as seen in hamster models. However, the study also finds there is no efficacy of the much-touted drug Hydroxychloroquine.

22 Jun 2020

Accelerating the Diagnosis and Treatment of Cancer with Mass-Spectrometry Based Techniques

An interview with Livia Eberlin, Assistant Professor at the University of Texas at Austin, discussing the development of mass-spectrometry based techniques for cancer diagnosis and improved clinical outcomes.

From Pittcon 16 Jun 2020

Hydroxychloroquine ineffective in animal SARS-CoV-2 infection

A new study by scientists from the U.S and U.K. and published on the preprint server bioRxiv in June 2020 reports that there is no evidence of efficacy for the drug hydroxychloroquine (HCQ) against infection with SARS-CoV-2 in hamsters or macaque models. This finding does not support the current widespread prophylactic and therapeutic use of HCQ in COVID-19.

14 Jun 2020

Pre-clinical data for Celltrion’s antiviral antibody treatment shows 100-fold reduction in viral load of SARS-CoV-2

Celltrion Group today announced positive pre-clinical results for its COVID-19 antiviral antibody treatment, with data demonstrating a 100-fold reduction in the viral load of SARS-CoV-2, the virus causing COVID-19.

4 Jun 2020

IL-6 blocker use in severe COVID-19 increases risk of secondary infections

With many hundreds of thousands of deaths due to the current COVID-19 pandemic, there is a rush to find an effective vaccine or drug against the virus. A new study on the preprint server medRxiv* in May 2020 shows that the use of some biologically plausible drugs may be counterproductive, and care should be taken when trying out unproven therapies.

22 May 2020

New technique reveals potentially treatable mutations in subset of prostate cancer patients

Prostate cancer patients who do not respond well to PSMA-targeted therapy often have potentially treatable mutations in their DNA damage-repair genes, according to research published in the May issue of The Journal of Nuclear Medicine.

20 May 2020

Novel radiotracer is an effective option for staging of prostate cancer

The novel radiopharmaceutical 18F-PSMA-1007 is both effective and readily available for detecting malignant prostate cancer lesions, according to research published in the April issue of The Journal of Nuclear Medicine.

11 May 2020

Huron Digital Pathology granted US patent for barcoding digital images; image search validation paper published in nature digital medicine

Huron Digital Pathology announced today that it has been granted a US patent for barcoding digital images. The invention forms the basis for Huron’s image search platform.

From Huron Digital Pathology 8 May 2020

Multicolor Immunohistochemistry (IHC): Going Beyond a Single Color

An interview with Dr. Will Howat at SfN 2018, discussing the possibilities and challenges of immunohistochemistry (IHC) beyond a single color!

From Abcam 1 May 2020

PiCoVacc vaccine candidate for COVID-19 effective in animal trials

In a new study available on the bioRxiv preprint server, a group of researchers from China report on the pilot-scale production of a purified inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus vaccine candidate (PiCoVacc), shown to induce virus-specific neutralizing antibodies in rats, mice, and non-human primates.

21 Apr 2020

High-resolution imaging with elastography could accurately spot breast cancer in surgical margins

A high-resolution, three-dimensional imaging technique, when combined with quantitative measurement of tissue elasticity, could accurately detect cancer within the resected margins of surgical specimens taken from patients undergoing breast-conserving surgery.

15 Apr 2020

Bioengineers combine standard microscopy, infrared light, and AI to assemble digital biopsies

NIBIB-funded bioengineers at the University of Illinois have combined standard microscopy, infrared light, and artificial intelligence to assemble digital biopsies that identify important molecular characteristics of cancer biopsy samples without dyes or labels.

5 Apr 2020

Immunosuppressive therapy does not increase risk of vulvar or vaginal cancer in women with IBD

In a new retrospective study, researchers found that the use of immunosuppressive therapy does not increase the occurrence or recurrence of vulvar or vaginal cancer in women with inflammatory bowel disease (IBD).

11 Mar 2020

AI taps human knowledge for faster and more accurate cancer diagnosis

A new system combining artificial intelligence with human knowledge promises faster and more accurate cancer diagnosis.

11 Mar 2020

Coronavirus pathology findings shows how the disease affects the body

Coronavirus disease (COVID-19) is spreading rapidly across the globe. Since COVID-19 is a new disease, scientists are racing to determine the nature of the virus and how it affects the human body. Now, a team of scientists, have shed light on how the virus affects the respiratory tract. The study provides essential information and descriptions of the early phase pathology of COVID-19 infection.

1 Mar 2020

Hybrid microscope could bring cancer diagnosis into the digital era

By adding infrared capability to the ubiquitous, standard optical microscope, researchers at the University of Illinois at Urbana-Champaign hope to bring cancer diagnosis into the digital era.

12 Feb 2020

NUS researchers discover new personalized tool for cancer diagnosis

A team of researchers from the National University of Singapore has discovered a new personalized tool to detect cancer, predict patient survivability and how well a cancer patient would respond to immunotherapy.

14 Jan 2020

AI identifies previously unknown features relevant to cancer prognosis

Artificial intelligence technology developed by the RIKEN Center for Advanced Intelligence Project in Japan has successfully found features in pathology images from human cancer patients, without annotation, that could be understood by human doctors.

18 Dec 2019

Research asserts ability of DRS technique to characterize healthy and non-healthy tissue

In an article published in the peer-reviewed SPIE publication Journal of Biomedical Optics (JBO), "Influence of neoadjuvant chemotherapy on diffuse reflectance spectra of tissue in breast surgery specimens," research observed across 92 ex vivo breast specimens suggests that there is little to no impact on the optical signatures of breast tissue after neoadjuvant chemotherapy.

27 Nov 2019

Researchers reveal ineffectiveness of some treatments in tackling early-stage lung cancer

Researchers from Tohoku University and Tohoku University Hospital have revealed why some existing cancer treatments are ineffective in tackling the early-stages of lung cancer. A team led by Professor Tetsuya Kodama investigated the ability of anti-cancer agents to affect early-stage lung metastatic tumors.