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Understanding how the immune system protects against fungal pathogenicity

The yeast Candida albicans colonizes mucosal surfaces and is usually harmless. However, under certain conditions it can cause dangerous infections.

15 Dec 2025

Exploring melatonin therapeutic potential in systemic lupus erythematosus

A recent review published in Current Molecular Pharmacology explores the therapeutic potential of melatonin in systemic lupus erythematosus (SLE), a complex autoimmune disease affecting multiple organs.

12 Dec 2025

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Researchers outline why organs from older donors are often discarded and identify the biological and immunological pathways that make them vulnerable to injury. They also highlight emerging rejuvenation technologies including machine perfusion, senotherapeutics, and regenerative strategies that could safely expand the donor pool.

11 Dec 2025

How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help

This narrative review synthesizes evidence showing that higher intake of ultra-processed foods is consistently associated with increased Crohn’s disease risk, with mechanistic pathways implicating emulsifiers, carrageenan, maltodextrin, titanium dioxide, sweeteners and salt. It also highlights that minimally processed dietary strategies, including EEN and CDED, show therapeutic promise, particularly in pediatric Crohn’s disease.

11 Dec 2025

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Injectable scaffold vaccine shows strong protection against implant-related MRSA

Research reveals that silica scaffolds can train the immune system against S. aureus, offering a novel approach to prevent orthopedic device infections.

4 Dec 2025

Sweat testing could transform drug monitoring and diabetes care

Innovative sweat sampling techniques could revolutionize diagnostics, offering insights into glucose levels and environmental toxins with minimal discomfort.

4 Dec 2025

Shared genetic roots between delirium and Alzheimer’s disease

This study reveals genetic and proteomic risk factors for delirium, offering insights into its etiology and potential biomarkers for prediction and prevention.

26 Nov 2025

How immune signals activate brain circuits to drive sickness-induced social withdrawal

MIT researchers have discovered how an immune system molecule triggers neurons in a specific brain circuit to shut down social behavior in mice modeling infection.

25 Nov 2025

Inflammatory biomarkers offer new insights for precision medicine in ischemic stroke

Ischemic stroke, a leading cause of disability and mortality worldwide, is a complex cerebrovascular event with outcomes heavily influenced by the inflammatory response.

20 Nov 2025

New patch may help heal the heart after a heart attack

A new patch developed by Texas A&M University researcher Dr. Ke Huang may offer a way to help the heart heal after a heart attack.

19 Nov 2025

Red meat raises inflammation marker CRP in clinical trials

The review analyzes red meat's effects on inflammatory biomarkers, revealing significant associations with CRP in specific adult subgroups and dietary contexts.

17 Nov 2025

Gut microbes may fuel allergic rhinitis symptoms

The study identifies gut microbiome alterations in allergic rhinitis, suggesting a gut-nose axis that could inform new treatment approaches for this condition.

17 Nov 2025

New insights into periodontitis reveal gender-specific inflammatory mechanisms

A study out of the University of North Carolina at Chapel Hill has unveiled new insights into the inflammatory processes behind periodontitis, a common and debilitating gum disease. Research conducted by UNC Adams School of Dentistry's Julie Marchesan, DDS, PhD, and UNC School of Medicine's Jenny Y. Ting, PhD, found that a part of the immune system called the inflammasome plays a key role in disease development, and that blocking this system prevents bone resorption only in males.

14 Nov 2025

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

Regular orange juice consumption reprograms immune-cell gene activity linked to blood pressure, lipid metabolism, and inflammation in healthy adults. The molecular effects differ by body weight, suggesting BMI-tailored benefits from this everyday beverage.

9 Nov 2025

Study identifies molecular brake that controls overactive killer T cells

"Why do immune cells that are supposed to eliminate viruses suddenly turn against our own body?"

6 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025

How walnuts combat inflammation and oxidative stress in the body

This review in Food Science & Nutrition synthesizes evidence showing that walnuts (Juglans regia L.) exert potent antioxidant, anti-inflammatory, apoptosis-regulatory, and immunomodulatory effects through bioactive compounds influencing mitochondrial, cytokine, and redox pathways.

3 Nov 2025

Immune cell dysregulation and inflammatory mediators shape epilepsy risk

Emerging evidence implicates immune dysregulation and neuroinflammation in the pathogenesis of epilepsy, yet the causal mechanisms remain unclear.

31 Oct 2025