Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Study reassures patients about semaglutide safety

Taking the weight loss medication semaglutide did not increase the risk of depressive symptoms, suicidal thoughts, or suicidal behavior in persons without known major mental health disorders, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania published this week in JAMA Internal Medicine.

4 Sep 2024

High-dose psilocybin shows promise for depression treatment

Researchers compare the effectiveness and acceptability of oral monotherapy with psychedelics for the treatment of depressive symptoms.

27 Aug 2024

High dose psilocybin shows similar antidepressant effects to escitalopram

High doses of psilocybin - the active ingredient in magic mushrooms - appears to have a similar effect on depressive symptoms as the selective serotonin reuptake inhibitor (SSRI) drug escitalopram, suggests a systematic review and meta-analysis published in The BMJ today.

21 Aug 2024

Perimenopausal women face increased risk of depression and mania, study reveals

Explore why women may be at higher risk of developing mania and major depressive disorder during perimenopause.

19 Aug 2024

New study links brain cell structures to memory loss in aging and dementia

Researchers assessed whether dendritic spine head diameter in the temporal cortex is a better predictor of episodic memory performance in older adults than synapse quantity, accounting for β amyloid plaques, neurofibrillary tangles, and sex.

12 Aug 2024

Violent dementia patients leave nursing home staffers and residents ‘scared to death’

Dan Shively had been a bank president who built floats for July Fourth parades in Cody, Wyoming, and adored fly-fishing with his sons.

9 Aug 2024

Study reveals curcumin’s antidepressant effects in obese type 2 diabetes patients

A randomized clinical trial (RCT) to investigate the effectiveness of curcumin in lowering depression among obese individuals with diabetes mellitus type 2 (T2DM).

30 Jul 2024

Irregular sleep and poor REM sleep linked to higher risk of chronic diseases

Longitudinal data from wearable devices linked to health records show that irregular sleep patterns and inadequate REM sleep increase the risk of chronic diseases like hypertension and depression. This emphasizes the importance of consistent and high-quality sleep for overall health.

22 Jul 2024

Poverty and mental Illness: A causal relationship revealed

Poverty and mental illness are not only linked, but there is also a causal relationship. This is the conclusion of researchers from Amsterdam UMC, the University of Edinburgh and the University of Modena.

11 Jul 2024

Innovative aiTBS therapy shortens treatment duration for bipolar disorder

A potential new treatment for bipolar disorder (BP) that significantly shortens treatment time has emerged, following a randomized clinical trial using accelerated intermittent theta burst stimulation (aiTBS).

11 Jul 2024

Digital screening for depression: Does automated feedback help?

The efficacy of two versions of automated feedback following internet-based depression screening on the severity of depression.

3 Jul 2024

Extended-release ketamine tablets offer new hope for treatment-resistant depression

The BEDROC trial found that extended-release ketamine tablets (R-107) significantly improve depressive symptoms in treatment-resistant depression patients, with the 180 mg dose showing the most efficacy. The treatment was well-tolerated with minimal side effects.

26 Jun 2024