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Unraveling the push-pull mechanism of neuron migration

The journey of a thousand miles begins with a single step, but for developing neurons, this first step relies on collaboration from multiple signaling pathways.

9 Jan 2025

Researchers identify key mechanism linking brain stress to Alzheimer's disease

Researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD).

23 Dec 2024

Spatial aging clocks reveal how T cells and neural stem cells shape brain aging

Researchers developed spatial aging clocks to map brain cell aging, revealing how T cells accelerate aging and NSCs rejuvenate neighboring cells, offering new insights into brain health and interventions.

22 Dec 2024

CNIC team develops a comprehensive set of genetic tools and mouse lines

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and its implications in health and disease.

14 Dec 2024

Key plasma proteins signal critical periods in brain aging

Researchers identified 13 plasma proteins linked to brain aging, uncovering dynamic patterns and biomarkers for early intervention in aging-related brain health.

10 Dec 2024

Study sheds light on Kif23's role in embryonic brain development and microcephaly

A team of researchers from Tohoku University, the National Center of Neurology and Psychiatry, and National Yang Ming Chiao Tung University has uncovered a novel molecular mechanism through which Kif23 (a motor protein belonging to the kinesin family) plays a vital role in embryonic brain development.

5 Dec 2024

Aging of lung stem cells drives iron deficiency and reduces capacity for tumor formation

Aging induces iron deficiency, reducing stem cell function and tumor growth while enhancing ferroptosis resistance, revealing new cancer prevention strategies.

5 Dec 2024

Fibroblastic reticular cells power immune defenses in lung cancer

Fibroblastic reticular cells (FRCs) create T-cell-supportive niches within lung cancer tumors, facilitating T-cell migration, clustering, and activation. This study highlights FRCs' potential as therapeutic targets to boost anti-tumor immunity in non-small cell lung cancer (NSCLC).

1 Dec 2024

Multiomic signatures identified for rapid detection and treatment of high-risk T-ALL

Researchers from Children's Hospital of Philadelphia (CHOP) have discovered the underlying biology that identifies a subset of patients with acute lymphoblastic leukemia who have a higher risk version of the disease and are more likely to relapse despite treatment.

25 Nov 2024

Stem-cell implants restore vision in patients with corneal stem cell deficiency

Researchers successfully tested the safety and preliminary efficacy of stem-cell-derived corneal implants, showing promise for restoring vision in patients with severe corneal damage.

12 Nov 2024

New discovery could lead to better treatments for drug-resistant leukemia

Scientists from Duke-NUS Medical School and their collaborators have identified an inherited genetic variation prevalent among East Asians that contributes to drug resistance, driving the aggressive growth of cancer cells in patients with chronic myeloid leukemia.

8 Nov 2024

Research shows how trained immunity links to cardiovascular disease

When thinking about the immune system, most people think about B and T cells and how they can be trained to recognize pathogens, preventing re-infections.

7 Nov 2024

Space-grown stem cells show promise for accelerating biotherapies

Stem cells grown in microgravity aboard the International Space Station (ISS) have unique qualities that could one day help accelerate new biotherapies and heal complex disease, two Mayo Clinic researchers say.

4 Nov 2024

Research reveals role of IGFBP3 in human lung development

Researchers of the University of Barcelona and the August Pi y Sunyer Biomedical Research Institute (IDIBAPS) have shown that the IGFBP3 protein plays a relevant role in human lung development.

1 Nov 2024

Human midbrain organoids: A promising tool in the fight against Parkinson's disease

Advancements in organoid technology are crucial for Parkinson's disease research, providing human-relevant models for studying disease and testing therapies.

23 Oct 2024

Adenine base editors show potential to correct X-CGD-causing mutations

A collaborative effort between investigators at the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) and Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder characterized by high susceptibility to infections.

16 Oct 2024