Small Molecules News and Research

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New platform predicts antibiotic resistance before it hits the clinics

Multidrug resistant bacteria kill five million people each year, with newly resistant germs emerging faster than scientists can develop treatments.

30 Jul 2025

Pyruvate identified as a promising oral treatment for ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory disease marked by intestinal pain, bleeding, and impaired gut barrier function.

29 Jul 2025

Study maps RNA shape-shifting mechanisms in human and bacterial cells

Apart from carrying the information to encode proteins in, RNA molecules can adopt intricate 2D and 3D structures.

28 Jul 2025

New imaging technique reveals how cells organize glucose processing

In a scientific first, researchers from Vanderbilt University and the University of California, San Diego, have generated a high-resolution metabolic "map" of how cells orchestrate glucose processing, revealing a hidden world where organelles and molecular complexes collaborate when responding to a rush of nutrients.

22 Jul 2025

MicroRNAs emerge as key players in soft tissue sarcoma

A new editorial was published in Volume 16 of Oncotarget on July 16, 2025, titled "microRNAs in soft tissue sarcoma: State of the art and barriers to translation."

18 Jul 2025

Optogenetic platform enables precise discovery of anti-aging therapeutics

A landmark study published in Cell has unveiled a first-of-a-kind optogenetic screening platform, developed by scientists at Integrated Biosciences, a biotechnology company integrating optogenetics, chemistry and AI to discover small molecule therapeutics for age-related diseases.

16 Jul 2025

Light-activated drug discovery identifies broad-spectrum antivirals

UC Santa Barbara researchers and collaborators from campus biotech spinoff Integrated Biosciences, as well as Harvard, MIT and genomics company Illumina Ventures are using optogenetics - the use of light to probe the functions of living tissue - to find compounds to help our bodies more effectively help themselves in times of physiological stress.

15 Jul 2025

Grandfather’s chemical exposure may influence granddaughter’s puberty timing

A grandfather's exposure to endocrine-disrupting chemicals may impact the age when his granddaughter starts her first period, according to preliminary data being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

13 Jul 2025

Hydrogels could be key to safer, smarter cancer drug delivery

Hydrogels could revolutionize cancer treatment by facilitating targeted drug delivery, reducing adverse effects, and enhancing therapeutic effectiveness.

11 Jul 2025

How hydrogels are shaping the future of targeted cancer drug delivery

A large-scale bibliometric analysis maps global research on hydrogels as next-generation drug delivery systems for cancer therapy. The study highlights emerging trends, key contributors, and future directions to advance precision medicine in oncology.

10 Jul 2025

New pretreatment method boosts islet transplant survival in diabetes

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a new preclinical study from Weill Cornell Medicine investigators. One combination of small molecules extended the cells' lives in female mice, and adding two molecules to the mixture boosted cell survival in male mice.

25 Jun 2025

Pandorabactins help pathogenic bacteria compete for iron in the lungs

An interdisciplinary research team led by the Leibniz-HKI in Jena has discovered a new group of bioactive natural compounds in pathogenic bacteria of the genus Pandoraea: pandorabactins.

19 Jun 2025

Stanford scientists grow vascularized heart and liver organoids

For over a decade, scientists have been growing organoids - small clusters of cells that mimic a particular organ - to serve as miniature biological models.

6 Jun 2025

Advancing GPCR drug discovery with fragment screening using GCI technology

Evotec's insights into GPCRs and waveRAPID technology reveal new opportunities in drug discovery, focusing on orphan receptors and innovative screening methods.

From Creoptix (A Malvern Panalytical brand) 23 May 2025

Gut bacteria and diet found to affect cancer treatment outcomes

A Ludwig Cancer Research study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer therapy.

22 May 2025

ORYL Photonics unveils the ORYL F1

On Wednesday, May 21 2025, ORYL Photonics introduces the ORYL F1, a novel automated laserbased platform for the measurement of solubility and aggregation of drug molecules in the Life Science industry.

22 May 2025

Blood and urine tests reveal how much ultra-processed food you really eat, study finds

Researchers developed and validated blood and urine metabolite scores that objectively measure ultra-processed food (UPF) intake in adults. These biomarker profiles accurately distinguished between high- and low-UPF diets and may transform nutrition research and public health monitoring.

21 May 2025

What makes H5N1 a pandemic risk and how can we stop it?

A new PEARLS article in PLoS Pathogens reviews the rapid evolution and pandemic potential of emerging influenza A viruses, with a focus on H5N1. It highlights scientific advances and future strategies to outpace the virus, from next-generation vaccines to AI-driven antiviral discovery.

19 May 2025

Extracellular vesicle detection moves forward with nanophotonic sensing and label-free imaging

Proteins play a vital role in human health and detecting them is crucial in medical research and clinical practice.

16 May 2025

Solgate streamlines SLC drug discovery with INTEGRA's automated pipetting systems

Solgate - a biotech start-up based in Klosterneuburg, Austria - is accelerating the development of new therapies targeting solute carrier (SLC) transporters using automated liquid handling systems from INTEGRA Biosciences.

14 May 2025