Structural Protein News and Research

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Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

In a recent study posted to the bioRxiv* preprint server, the team of researchers explored the protein-protein interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 1 (Nsp1) and host 40S and 43S ribosomal subunits.

15 Feb 2022

Structural protein vimentin facilitates SARS-CoV-2 entry into endothelial cells

Researchers suggest that extracellular vimentin may act as a coreceptor to allow for SARS-CoV-2 entry into cells.

14 Feb 2022

Study uncovers a series of natural products that can inhibit the main protease of SARS-CoV-2

The fight against the COVID-19 pandemic is an international scientific challenge regarding the search for strategies to fight the viral infection and prevent its damaging consequences.

7 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

A team of scientists from the United States has recently defined the substrate envelop of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study is currently available on the bioRxiv* preprint server while awaiting peer review.

31 Jan 2022

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

In a recent study, whole mRNA-seq was used to investigate the global effects of SARS-CoV-2 viral genes Nsp6, Nsp8, and M on the transcriptome of hPSC-CMs.

26 Jan 2022

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

In a recent study posted to the bioRxiv* preprint server, researchers evaluated the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated inflammatory marker interferon (IFN) repression in hosts.

25 Jan 2022

SARS-CoV-2 levels decrease when human SIRT5 is deleted or inhibited

Researchers examine the role of human sirtuin 5 (SIRT5) in SARS-CoV-2 infection.

10 Jan 2022

New study provides a mutational analysis of SARS-CoV-2

A new study investigates mutational waves in structural and non-structural protein evolutions of SARS-CoV-2 to better understand the virus’s evolution and epidemiology.

24 Dec 2021

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Researchers have experimentally proved that virus-related double-stranded RNA (dsRNA) and the sites of viral RNA synthesis are associated with one another.

22 Dec 2021

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

A new study shows that the ACE2 and RBD of coronavirus spike fragments have different binding strengths and dissociation rates when they are glycosylated and non-glycosylated.

13 Dec 2021

A new rapid and inexpensive PCR method to detect SARS-CoV-2 Omicron variant

A new study reports a method using four PCR tests to distinguish infection with the Omicron variant from that caused by other variants.

12 Dec 2021

Preclinical data shows enhanced T-cell responses & neutralization of SARS-CoV-2 variants with ImmunityBio heterologous vaccination

A new study supports the hypothesis that heterologous vaccination can provide an increased immune response against virus infection, supporting several other studies that have indicated similar events.

5 Dec 2021

Natural triterpenoids in licorice found to inhibit SARS-CoV-2

In new studies, researchers concluded that licorice triterpenoids could be candidates for anti-SARS-CoV-2 drug developments.

2 Dec 2021

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

In a recent study, published on the bioRxiv* preprint server, researchers identified human LRRC15 as an inhibitory receptor for SARS-CoV-2 entry, which directly binds to the receptor-binding domain (RBD) of the spike protein with a moderate affinity and inhibits spike-mediated entry.

29 Nov 2021

Structural Protein News and Research

Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

Structural protein vimentin facilitates SARS-CoV-2 entry into endothelial cells

Study uncovers a series of natural products that can inhibit the main protease of SARS-CoV-2

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

SARS-CoV-2 levels decrease when human SIRT5 is deleted or inhibited

New study provides a mutational analysis of SARS-CoV-2

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

A new rapid and inexpensive PCR method to detect SARS-CoV-2 Omicron variant

Preclinical data shows enhanced T-cell responses & neutralization of SARS-CoV-2 variants with ImmunityBio heterologous vaccination

Natural triterpenoids in licorice found to inhibit SARS-CoV-2

Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

Using metal nanoparticles to fight SARS-CoV-2

Antigenic cocktail produced in Nicotiana benthamian plant as a potential COVID-19 vaccine candidate

Functions of glycosylation in SARS-CoV-2 proteins and human receptor ACE2

SARS-CoV-2 Nsp1 deletions affect protein stability and translation inhibition

“Catching SARS-CoV-2 in the act” – viral infection of nasal mucosa spares nerve cells

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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