Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

UTSA receives $3.2 million CPRIT grant for developing new approach to fight against cancer

The University of Texas at San Antonio has been awarded a five-year $3.2 million grant from the Cancer Prevention & Research Institute of Texas.

2 Sep 2021

Baylor researchers use a faster, more cost-effective technology to discover SARS-CoV-2 inhibitor

Much progress has been made on the development of vaccines aiming at triggering human immunity to SARS-CoV-2, the virus that causes COVID-19. In addition, researchers at Baylor College of Medicine are involved in the development of antiviral drugs to treat infected individuals.

1 Sep 2021

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Argonne, industry and academia collaborate to bring innovative AI and simulation tools to the COVID-19 battlefront.

1 Sep 2021

Researchers develop adult lung organoids that represent all cell types

Since the COVID-19 pandemic reached the United States in early 2020, scientists have struggled to find laboratory models of SARS-CoV-2 infection, the respiratory virus that causes COVID-19. Animal models fell short; attempts to grow adult human lungs have historically failed because not all of the cell types survived.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

New machine learning method enhances computational prediction of RNA structures

Researchers present ARES (Atomic Rotationally Equivariant Scorer) – a machine learning method that significantly improves the computational prediction of RNA structures over previous approaches. Like proteins, RNA molecules twist and fold into intricate three-dimensional shapes that are crucial to their function.

27 Aug 2021

New discovery may lead to more effective treatments for osteoarthritis, other cartilage diseases

New information from a study reported on in STEM CELLS might result in more effective treatments for osteoarthritis and other cartilage diseases, as well as hereditary disorders affecting cartilage development.

25 Aug 2021

Researchers find clues to how lung damage develops in the aftermath of a respiratory infection

The deadliest time in a viral respiratory illness sometimes is actually after the virus is cleared from the body. Destructive processes that are set in motion during an infection crest in the weeks after the virus is defeated, leading to organ damage that can cause chronic illness or even death.

24 Aug 2021

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

New drugs are intended to help stop viral zoonoses - infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

20 Aug 2021

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Three independent studies in the Journal of Pharmaceutical Analysis explore the potential uses and applications of quantitative analytical tools in the characterization and quality assessment of biological and medicinal compounds.

19 Aug 2021

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

18 Aug 2021

ELRIG UK Announces Drug Discovery 2021 Event to Host SLAS’s Innovation AveNEW

The European Laboratory Research & Innovation Group today announced the programme details for Drug Discovery 2021.

From Society for Laboratory Automation and Screening (SLAS) 18 Aug 2021

Designing antimalarials with multiple targeting mechanisms of action

Malaria remains a serious global health threat. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance.

18 Aug 2021

Researchers receive $26.5 million NIH grant to pursue a new strategy for curing HIV

Over the last 40 years, HIV has shifted from a deadly and mysterious virus to one that can be controlled with daily drugs. But attempts to completely eliminate the virus from the bodies of people living with HIV, curing them for good, have failed.

17 Aug 2021

Using self-assembled drugs to achieve a breakthrough in cancer therapy

One of the most challenging aspects of cancer treatment is the huge variety of different tumors that can occur with each one potentially requiring a different solution because unfortunately, one drug does not fit all.

17 Aug 2021

ERS Genomics and Cellular Engineering Technologies Enter CRISPR/Cas9 License Agreement

ERS Genomics Limited and Cellular Engineering Technologies today announced a non-exclusive license agreement.

17 Aug 2021

VPS29 gene facilitates coronavirus cell entry

In a research paper recently uploaded to the bioRxiv* preprint server by Poston et al. (August 8th, 2021), common host factors amongst several zoonotic pathogens are explored by CRISPR-Cas9 screening in human lung cells, focusing in particular on the betacoronavirus genus.

11 Aug 2021

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

A new study describes the structure of a crucial enzyme present in SARS-CoV-2.

8 Aug 2021

Study: Neglecting development of therapeutics may repeat history and replicate vaccine inequality

A new policy report released today by the global non-profit research and development organization Drugs for Neglected Diseases initiative (DNDi) highlights how the development of therapeutics has been relatively neglected in the global response to COVID-19 and warns that with the few treatment innovations available principally in high-income countries, we risk repeating history and replicating the vaccine inequality that has become a defining characteristic of this global pandemic.

6 Aug 2021

Specific and sensitive biomarker in the blood predicts symptomatic COVID-19 infection

Researchers remain perplexed as to why some patients infected with SARS-CoV-2, the virus responsible for COVID-19, remain asymptomatic while other patients develop severe disease symptoms.

5 Aug 2021

Drug Discovery News and Research

Further Reading

UTSA receives $3.2 million CPRIT grant for developing new approach to fight against cancer

Baylor researchers use a faster, more cost-effective technology to discover SARS-CoV-2 inhibitor

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Researchers develop adult lung organoids that represent all cell types

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

New machine learning method enhances computational prediction of RNA structures

New discovery may lead to more effective treatments for osteoarthritis, other cartilage diseases

Researchers find clues to how lung damage develops in the aftermath of a respiratory infection

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Scientists identify the main components driving amyloid beta-associated synapse degeneration

ELRIG UK Announces Drug Discovery 2021 Event to Host SLAS’s Innovation AveNEW

Designing antimalarials with multiple targeting mechanisms of action

Researchers receive $26.5 million NIH grant to pursue a new strategy for curing HIV

Using self-assembled drugs to achieve a breakthrough in cancer therapy

ERS Genomics and Cellular Engineering Technologies Enter CRISPR/Cas9 License Agreement

VPS29 gene facilitates coronavirus cell entry

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

Study: Neglecting development of therapeutics may repeat history and replicate vaccine inequality

Specific and sensitive biomarker in the blood predicts symptomatic COVID-19 infection

Event guide: World ADC San Diego eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo