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FDA approved anti-inflammatory drug shows promise for treating alcohol use disorder and pain

A preclinical study from scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity-two issues that commonly co-occur with alcohol use disorder (AUD).

22 Apr 2025

Liquid biopsy offers new hope for early cancer detection

Cancer is one of the leading causes of death globally, with nearly 20 million new cases and 9.7 million deaths in 2022.

22 Apr 2025

Major breakthrough could turn IV drugs into oral treatments for brain cancer and Alzheimer's

A research team led by scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) made a major breakthrough with the potential to turn IV drugs into oral treatments for diseases like brain cancer and Alzheimer's disease.

21 Apr 2025

iPS cell transplants show early promise for treating Parkinson's disease safely

In a first-of-its-kind human trial, researchers transplanted iPS-cell-derived dopaminergic progenitors into patients with Parkinson’s disease and observed promising motor improvements with no serious safety concerns over 24 months. The therapy showed increased dopamine synthesis without tumor formation or graft-induced dyskinesia.

21 Apr 2025

Gut microbiome pattern predicts future heart attack risk in coronary heart disease patients

A specific gut microbiota pattern was found to predict new cardiovascular events in patients with coronary heart disease, based on data from the CORDIOPREV study. Researchers developed a microbiota-based risk score that may improve secondary prevention.

21 Apr 2025

Diabetes drugs GLP-1RA and SGLT2i lower dementia risk in older adults, study finds

A large population-based study found that GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors (SGLT2is), two classes of glucose-lowering drugs used in type 2 diabetes, were associated with a significantly reduced risk of Alzheimer’s disease and related dementias (ADRD). These findings suggest potential neuroprotective benefits and highlight drug repurposing as a promising strategy for ADRD prevention.

21 Apr 2025

Ursolic acid modulates estrogen conversion to alleviate MASLD inflammation

The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been escalating annually, positioning it as the leading cause of chronic liver disease worldwide.

21 Apr 2025

Hospitals can play key role in treating alcohol use disorder

Nearly 30 million adults in the United States experience alcohol use disorder (AUD), but the vast majority of people with this condition do not receive treatment.

21 Apr 2025

Natural supplement linked to slower biological aging and improved health

A new research paper was published in Aging (Aging-US) Volume 17, Issue 3, on March 14, 2025, titled "Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial."

21 Apr 2025

Molecular drivers and emerging treatments in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

20 Apr 2025

GOT2 as a metabolic and immunologic target in pancreatic cancer

A new wave of scientific interest is spotlighting GOT2—glutamic-oxaloacetic transaminase 2—as a compelling therapeutic target in the fight against pancreatic cancer, one of the most lethal and treatment-resistant malignancies.

20 Apr 2025

Evaluating hydronidone for the treatment of chronic hepatitis B-associated liver fibrosis

Liver fibrosis is a key process in the progression of chronic liver diseases. However, there are currently no drugs specifically designed to treat liver fibrosis.

18 Apr 2025

Why “eat 1 more” boosts fruit and vegetable intake more than “5 a day”

Setting specific goals, especially achievable ones like "Eat 1 more", significantly increased fruit and vegetable intake in both controlled and real-world environments. However, whether the goal was framed around current or future benefits had little impact on consumption.

18 Apr 2025

Vaccine trial shows promise for saving California condors from bird flu

Researchers evaluated the safety and immune response of a poultry-derived H5N1 avian influenza vaccine in black vultures and critically endangered California condors. The findings support the use of vaccination as a conservation tool against deadly avian flu outbreaks.

17 Apr 2025