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Researchers test commercial assays to detect SARS-CoV-2 antibodies six months after infection

Researchers at the Hospices Civils de Lyon (HCL) in France found that people infected with SARS-CoV-2 can develop antibodies that persist for up to six months. After testing commercial assays to detect antibodies, the Wantai antibody assay has a positivity rate of 100%.

14 Dec 2020

Emergence of resistant SARS-CoV-2 variant in immunocompromised patient following therapeutic antibody use

The focus is increasingly moving towards vaccine roll-out as the world faces the real possibility of the second year of social and economic restrictions.

14 Dec 2020

Epitope “megapools” could help determine role T cell immunity plays in COVID-19

Researchers in the United States and Australia have conducted a comprehensive analysis of the epitope recognition patterns associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans.

14 Dec 2020

Prior T cell immunity to SARS-CoV-2 unlikely to be the result of seasonal coronavirus infection

Scientists have suggested that a proportion of the population have pre-existing immunity to COVID-19 because of T cells primed against SARS-CoV-2 antigens.

14 Dec 2020

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

In the current COVID-19 pandemic, SARS-CoV-2 has led to millions of infections worldwide, with over 1.5 million deaths.

14 Dec 2020

Recovered COVID-19 patients exhibit persistent cellular immunity

Researchers at The Rockefeller University in New York have conducted a study showing that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – triggers persistent T cell responses that last for at least six months.

14 Dec 2020

SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development

A new study published in the pre-print server bioRxiv* explores the viral enzyme PLpro, encoded in the nonstructural protein nsp3, and its inhibitors. T

14 Dec 2020

RNA editing within host linked to SARS-CoV-2 variants

Since the start of the COVID-19 pandemic, the causative virus, SARS-CoV-2, has undergone several mutations.

14 Dec 2020

£453,000 grant awarded to boost research and development for COVID-19 antibodies

Fusion Antibodies, pre-clinical antibody discovery, engineering and supply experts, and Queen’s University Belfast, leader in innovation and impact, have been awarded a £453,000 grant from Invest Northern Ireland to further expand their COVID-19 targeted research and development efforts.

14 Dec 2020

Study unlocks some muscle cell secrets

A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are.

11 Dec 2020

Research provides new insights into Glioblastoma invasiveness

One of the hallmarks of Glioblastoma (GBM), the most aggressive type of brain cancer, is its high invasive capacity, which leads to its expansion into the normal brain tissue.

11 Dec 2020

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

According to the results of research led by the Complutense University of Madrid (UCM), one the various strategies deployed by the Leishmania parasite to avoid triggering the human immune system is to activate the SHP-1 protein.

11 Dec 2020

UCLA researchers identify gene that could help predict cervical cancer treatment response

UCLA researchers have identified a potential diagnostic marker that could help predict how likely someone with cervical cancer is to respond to the standard treatment of chemotherapy and radiation.

11 Dec 2020

Research reveals insights into potential drivers of 'wet' age-related macular degeneration

"Wet" age-related macular degeneration (AMD) is one of the most common causes of irreversible vision loss in the elderly, and it occurs when abnormal and leaky blood vessels form in the retina, in part due to inflammation.

11 Dec 2020

Innovations to fix our food systems could have unintended consequences

Protein derived from organic waste to feed livestock could decrease demand for soybean meal. This could lead to less deforestation caused by soy farming.

11 Dec 2020

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

Scientists present an insight into the RBD dynamics with physically distant residues in the spike protein, elaborating on the importance of predicted mutations for therapeutics.

11 Dec 2020

High expression of VRK1 protein can reduce survival in neuroblastoma patients

Researchers from the Departments of Cell Biology and Medical Physiology at the University of Seville have identified that a high expression of the human protein VRK1 is associated with tumour aggressiveness and low survival among neuroblastoma patients.

11 Dec 2020

New analysis method could pave the way for important breakthroughs in immunotherapy

In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukemia. This has awakened hopes that this analysis method could pave the way for important breakthroughs in immunotherapy research and treatment.

11 Dec 2020

Research shows how epithelial cells ward off viruses

A team led by Ludwig-Maximilians-Universitaet in Munich Researcher Veit Hornung has shown that a protein found in skin cells recognizes a specific nucleic acid intermediate that is formed during virus replication. This recognition process subsequently induces a potent inflammatory response.

11 Dec 2020

Genetic differences play a vital role in early diagnosis of Alzheimer's disease

The two clinically used methods for detecting amyloid pathology in Alzheimer's disease do not give unambiguous results, with the risk of incorrect or delayed care interventions.

11 Dec 2020

Protein C News and Research

Researchers test commercial assays to detect SARS-CoV-2 antibodies six months after infection

Emergence of resistant SARS-CoV-2 variant in immunocompromised patient following therapeutic antibody use

Epitope “megapools” could help determine role T cell immunity plays in COVID-19

Prior T cell immunity to SARS-CoV-2 unlikely to be the result of seasonal coronavirus infection

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

Recovered COVID-19 patients exhibit persistent cellular immunity

SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development

RNA editing within host linked to SARS-CoV-2 variants

£453,000 grant awarded to boost research and development for COVID-19 antibodies

Study unlocks some muscle cell secrets

Research provides new insights into Glioblastoma invasiveness

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

UCLA researchers identify gene that could help predict cervical cancer treatment response

Research reveals insights into potential drivers of 'wet' age-related macular degeneration

Innovations to fix our food systems could have unintended consequences

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

High expression of VRK1 protein can reduce survival in neuroblastoma patients

New analysis method could pave the way for important breakthroughs in immunotherapy

Research shows how epithelial cells ward off viruses

Genetic differences play a vital role in early diagnosis of Alzheimer's disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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