Enzyme News and Research

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Diuretics work better than newer and more costly medicines for diabetics with high blood pressure

Diuretics (water pills) work better than newer and more costly medicines in the treatment of high blood pressure and prevention of some forms of heart disease in people with type 2 diabetes, according to results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

28 Jun 2005

Researchers successfully treat laboratory model of a lysosomal storage disease called GM1

Physicians might one day be able to treat a disease that destroys brain cells in children using genetically modified cells to transport a "drug" to the site of the dying neural cells (cells that transmit impulses).

27 Jun 2005

Enzyme known as cathepsin G may be a target for anti-inflammatory treatments

The finding by researchers at Washington University School of Medicine in St. Louis shows that an enzyme known as cathepsin G regulates the ability of immune cells known as neutrophils to secrete chemicals that attract other immune cells and start the local inflammatory process. Over time, the excessive accumulation of immune cells can lead to tissue and cartilage damage in joints, causing pain and limiting mobility.

27 Jun 2005

Technique called phylogenetic footprinting reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication - and they did it solely by computer keystrokes and mouse clicks.

27 Jun 2005

Metabasis and Merck collaborate to develop new treatment for diabetes, hyperlipidemia and obesity

Metabasis Therapeutics and Merck announced today that they have formed a collaboration to research, develop and commercialize novel small molecule therapeutics with potential to treat several diseases, including type II diabetes, hyperlipidemia and obesity, by activation of an enzyme in the liver called AMP-activated Protein Kinase (AMPK).

27 Jun 2005

Naturally produced 'cannabis' in the brain helps with pain relief

Researchers in the United States have found that a cannabis like chemical produced naturally in the brain helps with pain relief.

23 Jun 2005

Chemicals found in everyday products and food have subtle but potentially damaging effects on sperm fertility

Professor Lynn Fraser told the 21st annual conference of the European Society of Human Reproduction and Embryology today (Wednesday), that her previous research had shown that certain chemicals known to mimic the female sex hormone, oestrogen, could individually affect the correct functioning of mouse sperm, but now her new research showed that when the chemicals were combined they had an even stronger effect.

21 Jun 2005

Researchers discover mechanism that causes a protein to clump together in brain cells of people with Parkinson's disease

The protein clumping is part of a "vicious cycle," the researchers said. As the proteins cluster, they inhibit an enzyme that normally breaks them down, leading to the formation of even more masses.

21 Jun 2005

Scientists identify inhibitors of the anthrax toxin

A collaborative team of scientists led by The Burnham Institute's Maurizio Pellecchia, Ph.D., has identified inhibitors of the anthrax toxin, termed lethal factor ("LF") that could be developed into an emergency treatment for exposure to inhalation anthrax.

21 Jun 2005

Enzyme family plays role in Alzheimer's

The route to a treatment for Alzheimer's disease may have become more straightforward with the discovery that a key enzyme known to have a major role in this disease is in fact part of a family of enzymes. Only some family members play a role in the progression of this brain-wasting illness, new research at the University of Toronto has found.

20 Jun 2005

First blood test to help predict a patient's risk for ischemic stroke

The U.S. Food and Drug Administration (FDA) has approved the first blood test designed to help predict a patient's risk for ischemic stroke, the most common type of stroke and one of the nation's leading causes of long-term disability affecting approximately 700,000 people per year.

19 Jun 2005

U.S. scientists have successfully engineered blood vessels from human vascular cells in the lab

Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. For elderly patients tissue-engineered arteries could provide grafts for bypass surgery.

16 Jun 2005

Scientists discover new way of bringing "bio-prospecting" out of the rainforest and into the lab

Nature is a seemingly endless storehouse of interesting - and potentially life-saving - biological molecules. But tracking down and harvesting those chemicals in their natural form can be time-consuming, expensive and unreliable.

15 Jun 2005

FDA approves Xeloda (capecitabine) oral chemotherapy

Roche announced today that the U.S. Food and Drug Administration (FDA) has approved Xeloda (capecitabine) -- an innovative oral chemotherapy -- for the adjuvant (post-surgery) treatment of patients with Dukes' C colon cancer.

15 Jun 2005

Promising new tuberculosis drug enters clinical trial

A promising new drug candidate that may be effective against both actively dividing and slow-growing Mycobacterium tuberculosis (M. tb) has begun testing in humans, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, announced this week.

15 Jun 2005

Arteries bio-engineered from elderly cells

Researchers from Duke University's Medical Center and Pratt School of Engineering have demonstrated that they can grow new human blood vessels from cells taken from patients who especially need such assistance – older adults with cardiovascular disease.

14 Jun 2005

Study examines biomarkers for response to erlotinib in glioma

Researchers have found two biomarkers that, in patients with a malignant type of brain tumor called glioblastoma multiforme, were associated with response to the cancer drug erlotinib (Tarceva).

14 Jun 2005

Orlistat, a drug that decreases fat absorption, appears helpful for improving weight management in obese adolescents

When combined with diet, exercise and behavioral therapy, orlistat, a drug that decreases fat absorption, appears helpful for improving weight management in obese adolescents, compared with placebo, according to an article in the June 15 issue of JAMA: The Journal of the American Medical Association.

14 Jun 2005

Ruboxistaurin shows favorable effects on kidney damage and function in people with type 2 diabetes and nephropathy

Eli Lilly and Company today announced encouraging results from a one-year pilot study examining the effect of ruboxistaurin mesylate in persons with type 2 diabetes and kidney disease (also known as "diabetic nephropathy").

12 Jun 2005

Researchers discover how microRNA are involved in the development of heart muscle

Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA - a chemical cousin of DNA - helps fine tune the production of a key protein involved in the early development of heart muscle.

12 Jun 2005

Enzyme News and Research

Diuretics work better than newer and more costly medicines for diabetics with high blood pressure

Researchers successfully treat laboratory model of a lysosomal storage disease called GM1

Enzyme known as cathepsin G may be a target for anti-inflammatory treatments

Technique called phylogenetic footprinting reveals new gene regulation system

Metabasis and Merck collaborate to develop new treatment for diabetes, hyperlipidemia and obesity

Naturally produced 'cannabis' in the brain helps with pain relief

Chemicals found in everyday products and food have subtle but potentially damaging effects on sperm fertility

Researchers discover mechanism that causes a protein to clump together in brain cells of people with Parkinson's disease

Scientists identify inhibitors of the anthrax toxin

Enzyme family plays role in Alzheimer's

First blood test to help predict a patient's risk for ischemic stroke

U.S. scientists have successfully engineered blood vessels from human vascular cells in the lab

Scientists discover new way of bringing "bio-prospecting" out of the rainforest and into the lab

FDA approves Xeloda (capecitabine) oral chemotherapy

Promising new tuberculosis drug enters clinical trial

Arteries bio-engineered from elderly cells

Study examines biomarkers for response to erlotinib in glioma

Orlistat, a drug that decreases fat absorption, appears helpful for improving weight management in obese adolescents

Ruboxistaurin shows favorable effects on kidney damage and function in people with type 2 diabetes and nephropathy

Researchers discover how microRNA are involved in the development of heart muscle

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