Immunization News and Research

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New vaccine, enhanced surveillance needed to combat childhood pneumonia

A rise in vaccine-resistant bacteria shows the need for a new vaccine to fight childhood empyema after a spike in hospitalisations, a new UNSW study reveals.

25 Feb 2021

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

A new preprint research paper posted to the bioRxiv server reports the rapid emergence of variants within an infected individual. The evolution of the virus within an infected host is not excluded by the close similarity between the consensus sequences of single-person SARS-CoV-2, since the number of viral copies is at its peak soon after infection occurs and before the host develops adaptive immunity.

23 Feb 2021

New rapid diagnostic tests can differentiate between COVID-19 variants and multiple viruses

University of Minnesota Medical School researchers have developed two new rapid diagnostic tests for COVID-19 - one to detect COVID-19 variants and one to help differentiate with other illnesses that have COVID-19-like symptoms.

23 Feb 2021

Calling all vaccinators: Closing the next gap in Covid supply and demand

Beating back Covid right now comes down to balancing supply and demand.

23 Feb 2021

After billions of dollars and dozens of wartime declarations, why are vaccines still in short supply?

The U.S. government has invested billions of dollars in manufacturing, used a wartime act dozens of times to boost supplies and yet there's still not enough covid vaccine on the way to meet demand — or even the government's own goals for national immunization.

23 Feb 2021

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Scientists at the University of Salzburg and Pantec Biosolutions AG have developed a laser-facilitated epicutaneous immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The model has induced angiotensin-converting enzyme 2 (ACE2) blocking antibodies in mice.

23 Feb 2021

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

The study began with the generation of recombinant (r)SA11 rotaviruses, into which segment 7 modified RNAs were introduced. These encoded sequences for the non-structural protein NSP3 and some parts of the viral spike.

23 Feb 2021

Australia shows an increase in COVID-19 vaccine hesitancy, says study

A disturbing new study details an increase in vaccine hesitancy among many Australians over the period of August 2020 to January 2021. This may have serious implications for the country’s ability to achieve universal immunization.

23 Feb 2021

COVID-19 vaccine candidate shows potential against SARS-CoV-2 and potential future zoonotic coronaviruses

A new study sheds light on the threat posed by future zoonotic coronaviruses to make similar leaps across species barriers to infect human beings and cause other pandemics.

22 Feb 2021

Could an intranasal adjuvant to vaccines boost immunity against SARS-CoV-2 variants?

A research team from the University of Michigan Medical School, USA, developed a supplementary intranasal treatment to improve COVID-19 vaccine response and its effects on long-lasting immunity from other variants, such as the B.1.351 variant first found in South Africa.

22 Feb 2021

Mucosal delivery of IFNs a good strategy for COVID-19 prophylaxis post-exposure

Researchers from the UK and Germany recently reported a comprehensive characterization of the SARS-CoV-2 response of human nasal epithelial cells, revealing a response dominated by IFN-I/IIIs. Also, recombinant IFN-I/III treatment was found to efficiently block the replication of SARS-CoV-2, which suggests that mucosal delivery of IFNs may be a good strategy for prophylaxis post-exposure.

22 Feb 2021

SARS-CoV-2 DNA vaccine tested in animal model

A team of experts has tested the immune responses elicited by mucosal homologous plasmid and a heterologous immunization strategy using a plasmid vaccine and a Modified Vaccinia Ankara (MVA) expressing SARS-CoV-2 spike (S) and nucleocapsid (N) antigens.

21 Feb 2021

O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines

The mapping of O-glycosites requires instruments that can support electron transfer dissociation (ETD) fragmentation. In a new study published on the bioRxiv preprint server, researchers report their results on whether O-glycosylation patterns affect immunogens for vaccine development.

18 Feb 2021

Could measles virus vectors be used for a new COVID-19 vaccine?

A research team at the Institut Pasteur in France describes the successful development of such a vaccine utilizing a measles virus vector.

18 Feb 2021

SARS-CoV-2 D614G mutation associated with lower antibody binding

The onset of the COVID-19 pandemic has brought about an international effort to uncover the biology of its causative agent, SARS-CoV-2, and to develop effective and safe antivirals to contain and treat the infection. A new study by a team of researchers in France and Sweden discusses one such study, exploring the relative immunogenicity of the three main structural proteins of the virus.

18 Feb 2021

How have COVID-19 pandemic school closures impacted the health of children globally?

A new study by researchers in the US and the UK explores the damage caused by school closures to educational progress, health, and well-being in children and young people globally.

18 Feb 2021

Advancements in DNA vaccines against COVID-19

The rapid spread of the pathogen and the increasing number of cases highlight the need for an effective and safe vaccine. As vaccination efforts roll out in many countries, new types of vaccines, like deoxyribonucleic acid (DNA) vaccines, are under research..

17 Feb 2021

GDP significantly associated with greater COVID-19 vaccine distribution

ccording to a report published by the Bureau of Economic Analysis, the world's gross domestic product (GDP) fell by 4.6% in 2020. As per WHO estimates, at least 65% of the world population should be vaccinated to contain the virus's spread and achieve herd immunity.

17 Feb 2021

Purely mathematical perspective on delaying the second dose of the SARS-CoV-2 vaccine

High demand for the vaccines has raised questions as to whether it would be better in the long term to ensure that as much of the population as possible has received the first dose, i.e., vaccinate twice as many people with a lower rate of efficacy.

17 Feb 2021

Development of malaria vaccines deserves urgent attention just like COVID-19

Developing vaccines to fight malaria deserves urgent attention just like COVID-19, argues Damaris Matoke-Muhia.

17 Feb 2021

Immunization News and Research

New vaccine, enhanced surveillance needed to combat childhood pneumonia

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

New rapid diagnostic tests can differentiate between COVID-19 variants and multiple viruses

Calling all vaccinators: Closing the next gap in Covid supply and demand

After billions of dollars and dozens of wartime declarations, why are vaccines still in short supply?

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

Australia shows an increase in COVID-19 vaccine hesitancy, says study

COVID-19 vaccine candidate shows potential against SARS-CoV-2 and potential future zoonotic coronaviruses

Could an intranasal adjuvant to vaccines boost immunity against SARS-CoV-2 variants?

Mucosal delivery of IFNs a good strategy for COVID-19 prophylaxis post-exposure

SARS-CoV-2 DNA vaccine tested in animal model

O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines

Could measles virus vectors be used for a new COVID-19 vaccine?

SARS-CoV-2 D614G mutation associated with lower antibody binding

How have COVID-19 pandemic school closures impacted the health of children globally?

Advancements in DNA vaccines against COVID-19

GDP significantly associated with greater COVID-19 vaccine distribution

Purely mathematical perspective on delaying the second dose of the SARS-CoV-2 vaccine

Development of malaria vaccines deserves urgent attention just like COVID-19

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