Molecule News and Research

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Exploiting biology's own chemical toolbox...

Exploiting biology's own chemical toolbox, researchers have developed a new technique that will allow them to modify specific sequences within a DNA molecule. The approach will not only help reveal the impact of biochemical alterations to DNA, but could have far-reaching implications for DNA-based medical diagnosis and nanobiotechnology.

28 Nov 2005

Potential new treatment for pancreatic cancer

Johns Hopkins Kimmel Cancer Center researchers are encouraged by early results of a treatment vaccine for pancreatic cancer, a disease with few options and low odds for long-term survival.

28 Nov 2005

Study finds AKT blocks cancer cell motility

PIn investigating the molecular mechanisms of cancer cell motility - the unique property that enables cancer to spread from its primary origin to other parts of the body - researchers have uncovered a surprising role for the AKT/PKB (protein kinase B) enzyme

26 Nov 2005

Tuberculosis research

It is estimated that two billion people--or one-third of the world's population--are chronically infected without active symptoms. Nine million new cases of active disease are diagnosed annually, resulting in two million deaths.

26 Nov 2005

Study reveals how T cells analyze and react to the signals of infection at the immunological synapse

The immune system is highly complex. The cast of characters alone required to marshal an immune response to a foreign invader can number in the millions as the body's soldiers, T cells, are called into action.

20 Nov 2005

Six gene variants predict heart muscle damage after cardiac surgery

Duke University Medical Center researchers have found that patients with six specific variants of genes involved in the body's immune response are significantly more likely to suffer damage of heart tissue after cardiac surgery.

16 Nov 2005

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Despite the fact that clogged arteries in the legs usually mean clogged arteries near the heart, doctors often fail to give heart-protecting drugs to people with severe leg blood vessel blockages, a new University of Michigan-led study finds.

15 Nov 2005

Vietnamese researchers say bird flu already resisant to Tamiflu

Scientists in Vietnam are concerned that the deadly bird flu may have infected two more people, and they suspect the virus may have mutated into a more dangerous form which could spread in mammals, and cause outbreaks in poultry.

15 Nov 2005

Better understanding of cancer cachexia

New research shows that a wasting condition responsible for nearly a third of all cancer deaths involves the loss of an essential muscle protein that is also lost in people with muscular dystrophy.

15 Nov 2005

FLT-1 blockers, cutting the legs of leukaemia

Leukaemia is characterised by an uncontrolled growth of abnormal blood cells in the bone marrow (BM).

14 Nov 2005

First step in exploring the GnRH reproduction-related circuitry in the brain

Howard Hughes Medical Institute researchers have discovered a vast network of neurons in the brain of mice that governs reproduction and controls the effects of reproductive status on other brain functions.

14 Nov 2005

Lifelong exercise decreases cellular aging in the brain

In the first study to show that lifelong exercise decreases cellular aging in the brain, scientists from the McKnight Brain Institute of the University of Florida say that moderately active rats have healthier DNA and more robust brain cells than their less active counterparts. The research was presented at the Society for Neuroscience's 35th annual meeting in Washington, D.C.

13 Nov 2005

Cellular signal may determine life or death for damaged brain cells

Scientists at the Universities of Heidelberg and Ulm and a unit of the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, have discovered that a specific signal within brain cells may determine whether they live or die after a stroke.

13 Nov 2005

Nanogen issued patent relating to synthetic polymer hydrogels

Nanogen has announced it was issued Patent No. 6,960,298, "Mesoporous permeation layers for use on active electronic matrix devices" by the U.S. Patent and Trademark Office.

8 Nov 2005

Statin drug reverses learning and attention deficits in a mouse model of the genetic disorder Neurofibromatosis type I

This week, researchers report evidence that a statin drug already shown to be safe for use in humans has proven effective at correcting cell-cell communication and curing learning disfunction in a mouse model of Neurofibromatosis type I, a human genetic disorder that causes learning disabilities in millions of people worldwide.

7 Nov 2005

Anti-aging hormone called Klotho actions explained

Scientists recently discovered an anti-aging hormone called Klotho. Now, a new study shows that this protein acts by increasing the cell's ability to detoxify harmful reactive oxygen species.

7 Nov 2005

New understanding of sphingosine kinases called SphK1 and SphK2

Virginia Commonwealth University Massey Cancer Center researchers have found that two enzymes that catalyze the same reaction and produce the same product have opposite effects on cell growth and death.

7 Nov 2005

Gene silencing and microRNA discovery

One of the body's primary strategies for regulating its genome is a kind of targeted gene silencing orchestrated by small molecules called microRNAs, or miRNAs.

7 Nov 2005

EphA2 represents a promising treatment target for glioblastoma multiforme

Researchers at Wake Forest University Baptist Medical Center have identified a second promising treatment target for glioblastoma multiforme, one of the most deadly types of brain tumors. The research results are reported in the October issue of Molecular Cancer Research.

1 Nov 2005

Molecule called metallacarborane appears to fight HIV protease

A molecule consisting of two "cages" of metallic atoms bound to carbon has shown great promise in preliminary tests of becoming a new weapon in the anti-HIV arsenal, researchers at UT Southwestern Medical Center report.

1 Nov 2005