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Discovery of new features of a key quality-control mechanism in our cells

Mutations in genes are the basis of evolution, so we owe our existence to them. Most mutations are harmful, however, because they cause cells to build defective proteins. So cells have evolved quality control mechanisms that recognize and counteract genetic mistakes.

9 Oct 2005

Gene variation may play fundamental role in the development and spread of cancer in the body

New research shows that a small gene variation that increases the risk of inherited cancer can also arise during the development of spontaneous, or non-inherited, tumors.

9 Oct 2005

Gut antibody could prove to be a promising drug target for Crohn's disease

A collaboration led by the Burnham Institute for Medical Research has found that an antibody which binds to an unusual sugar molecule residing in the gut halts the inflammation seen in Crohn's disease and other intestinal inflammations. The antibody could prove to be a promising drug target for these common chronic intestinal disorders.

9 Oct 2005

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

The first close-up look at a pro-inflammatory signaling molecule involved in immune response in mammals suggests that researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model, scientists say.

4 Oct 2005

Brain mechanism may play a central role in regulating anxiety and alcohol-drinking

The finding, by researchers supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), could provide important clues about the neurobiology of alcohol-drinking behaviors in humans.

3 Oct 2005

Beta glucan may help treat skin disorders and remove fine lines and wrinkles

The fight against aging has received a scientific boost thanks to an innovative study done in part by a University of Alberta spin-off company--research that dispels a hard-held belief about the natural ingredient, beta glucan.

3 Oct 2005

Protein found in the brain is genetically linked to alcoholism and anxiety

The researchers studied rats selectively bred for high alcohol preference (P rats), which were found to have high anxiety levels and consume greater amounts of alcohol than alcohol non-preferring (NP) rats.

3 Oct 2005

Lack of oxygen in body tissues creates a defect of red blood cells that further exacerbates the condition by constricting blood vessels in the lung

What's more, the team demonstrated through studies in people and animals that inhalation of a 'souped up' form of nitric oxide, which targets red blood cells, reverses the blood abnormality to restore normal lung pressure.

3 Oct 2005

New insights that advance the current model of protein motility and muscle contraction

Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction.

3 Oct 2005

Discovery of mechanism in the body that could lead to autoimmune diseases

Researchers at National Jewish Medical and Research Center have discovered a mechanism in the body that could lead to autoimmune diseases, such as lupus, rheumatoid arthritis, or diabetes.

3 Oct 2005

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

3 Oct 2005

Discovery may lead to development of more effective antibiotics

Researchers at the Georgia Institute of Technology and the John Innes Centre in the United Kingdom have uncovered a mechanism with which disease-causing bacteria may thwart the body's natural defense responses. The findings, which could ultimately lead to the development of more effective antibiotics, appear in the September 29, 2005 issue of the journal Nature.

28 Sep 2005

New Stat1 and interferon findings

By altering a molecule called Stat1, which is involved in cellular immune signaling, scientists have succeeded in making the molecule more responsive and thus more efficient. This old protein with a new twist may eventually be used to improve the body's defense against infection.

28 Sep 2005

Transplanted insulin-producing cells survive better when the activation of NKT cells are blocked

Scientists in Japan have found a way to improve on a promising diabetes treatment. In the October 3 issue of The Journal of Experimental Medicine, Masaru Taniguchi and colleagues report that transplanted insulin-producing cells survive better when the activation of a specific type of immune cell is blocked.

27 Sep 2005

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

A team from the University of Pennsylvania School of Medicine has shown that by using a cancer vaccine based on the bacterium Listeria monocytogenes, they can cure mice with established breast tumors. Cancer vaccines, which are more properly described as immunotherapy, work by boosting an immune response against tumor-associated antigens.

27 Sep 2005

Pulsing heart cell provides clues into how heart disease develops

A pulsing heart cell is giving Oregon Health & Science University researchers insight into how it sends and receives signals, and that's providing clues into how heart disease and other disorders develop.

27 Sep 2005

Findings increase understanding of how an organism's body size is determined and how the speed of its development is controlled

In particular, the work sheds light on the molecular and cellular pathways that act to convey information about a growing organism's size, as well as on pathways that use that information to correctly time critical transitional events during development.

26 Sep 2005

Molecule News and Research

Discovery of new features of a key quality-control mechanism in our cells

Gene variation may play fundamental role in the development and spread of cancer in the body

Gut antibody could prove to be a promising drug target for Crohn's disease

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

Brain mechanism may play a central role in regulating anxiety and alcohol-drinking

Beta glucan may help treat skin disorders and remove fine lines and wrinkles

Protein found in the brain is genetically linked to alcoholism and anxiety

Lack of oxygen in body tissues creates a defect of red blood cells that further exacerbates the condition by constricting blood vessels in the lung

New insights that advance the current model of protein motility and muscle contraction

Discovery of mechanism in the body that could lead to autoimmune diseases

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

Discovery may lead to development of more effective antibiotics

New Stat1 and interferon findings

Transplanted insulin-producing cells survive better when the activation of NKT cells are blocked

Cancer vaccine based on the bacterium Listeria monocytogenes, can cure mice with breast tumors

Pulsing heart cell provides clues into how heart disease develops

Findings increase understanding of how an organism's body size is determined and how the speed of its development is controlled

Discovery of molecule that causes transverse myelitis

Tumor formation is generated by a complex interaction of both mechanical as well as chemical signals

Nanogen issued patent relating to biological screening device

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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