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First study to test the role of RNA chemical modifications on immunity

The investigators published their findings in the August issue of Immunity. "We think this study will open a new area of research in understanding how our immune systems protect us," says Weissman.

23 Aug 2005

Chemists synthesize new class of carbenes - potential for pharmaceutical industry

Chemists at the University of California, Riverside have synthesized a new class of carbenes - molecules that have unusual carbon atoms - that is expected to have wide applications in the pharmaceutical industry, ultimately resulting in a reduction in the price of drugs.

22 Aug 2005

Increasing sugar processing in the liver may lead to future treatments for diabetes, obesity

Researchers at the University of Minnesota have shown that increasing the concentration of a key regulator involved in glucose metabolism can improve the way the liver produces and disposes of the sugar glucose, the primary fuel of the body. Finding ways to increase that concentration could provide a treatment for diabetes and obesity.

22 Aug 2005

SH2-B enhances brain's leptin sensitivity - may lead to clues for treatment of obesity and diabetes

What do laboratory mice at the University of Michigan Medical School have in common with millions of overweight Americans? Like many of us, these mice just can't stop eating.

18 Aug 2005

Mutations in the targets of designer drugs critically influence their effectiveness

Two designer cancer drugs differed dramatically in a laboratory test comparing their ability to shut down a mutant, overactive growth signal in lung cancer cells, reports a team headed by scientists at the Dana-Farber Cancer Institute.

18 Aug 2005

Defects in newly discovered pathway may be an overlooked cause of anemia

Researchers studying zebrafish that die from anemia have discovered a new pathway for the synthesis of heme, the deep red, iron-containing molecule that is a component of hemoglobin and myoglobin.

18 Aug 2005

First clear evidence that olfaction is uniquely a "dual" sense

In the August 18, 2005, issue of Neuron, researchers report that the smell of chocolate activated different brain regions according to whether the odor was introduced into the olfactory system through the mouth or through the nose.

17 Aug 2005

Biochemical switch that affects how neurons fire in a part of the brain associated with learning

Researchers at UT Southwestern Medical Center have identified a biochemical switch that affects how neurons fire in a part of the brain associated with learning, findings that may aid in understanding schizophrenia and Alzheimer's disease.

17 Aug 2005

Decline in energy production by mitochondria appears to be a key problem leading to insulin resistance

A detectable decline in energy production by mitochondria - the organelles that are the cell's furnace for energy production - seems to be a key problem leading to insulin resistance, and thus to type 2 diabetes, according to studies by Howard Hughes Medical Institute researchers.

16 Aug 2005

Large-scale computer simulations reveal new insights into antibiotic resistance

Large-scale computer simulations have pinpointed a tiny change in molecular structure that could account for drug resistance in Streptomices pneumoniae, the organism that causes childhood pneumonia and claims 3.5 million lives a year, mainly in developing countries.

15 Aug 2005

How negatively charged lipids stick to negatively charged DNA and self-organize into structures

Scientists studying the structure and interaction of negatively charged lipids and DNA molecules have created a "cookbook" for a class of nontoxic DNA delivery systems that will assist doctors and clinicians in the safe and effective delivery of genetic medicine.

13 Aug 2005

Findings could lead to gene therapy cure for childhood blindness

In findings that could lead to curing some forms of congenital blindness through gene therapy, researchers at UCLA have discovered that RPE65, a gene missing in infants born with the blinding disease Leber congenital amaurosis, is also a key enzyme in the visual cycle. The identity of this enzyme has long been a mystery to scientists.

11 Aug 2005

Molecule News and Research

First study to test the role of RNA chemical modifications on immunity

Chemists synthesize new class of carbenes - potential for pharmaceutical industry

Increasing sugar processing in the liver may lead to future treatments for diabetes, obesity

SH2-B enhances brain's leptin sensitivity - may lead to clues for treatment of obesity and diabetes

Mutations in the targets of designer drugs critically influence their effectiveness

Defects in newly discovered pathway may be an overlooked cause of anemia

First clear evidence that olfaction is uniquely a "dual" sense

Biochemical switch that affects how neurons fire in a part of the brain associated with learning

Decline in energy production by mitochondria appears to be a key problem leading to insulin resistance

Large-scale computer simulations reveal new insights into antibiotic resistance

How negatively charged lipids stick to negatively charged DNA and self-organize into structures

Findings could lead to gene therapy cure for childhood blindness

Early detection of Alzheimer's coming soon?

Cells direct membrane traffic by channel width

Biochemists reveal the first structural details of microcompartments

Firefly protein lets researchers monitor molecule known as IKK (for IKappa kinase) linked to cancer

Scientists enhance the anti-cancer properties of a digitalis, a drug commonly used to treat heart disease

Genelabs drug discovery team advances compounds against the hepatitis C virus

Natural killer cells help understand responses to bone marrow transplants

Omega-6 fatty acids promote the growth of prostate tumor cells in the laboratory

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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