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Hormonal imbalance and gut microbes linked to cognitive deficits in patients with PitNETs

Pituitary neuroendocrine tumors (PitNETs) are commonly associated with visual disturbances and endocrine abnormalities; however, many patients also experience cognitive deficits, particularly in memory, attention, and executive function, which significantly affect quality of life.

9 Mar 2026

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.

9 Mar 2026

Largest genetic study classifies 14 psychiatric disorders into five major groups

Although mental disorders have multifactorial causes, genetics can explain some of them, yet this field remains largely unexplored in terms of guiding diagnoses and treatments.

9 Mar 2026

Brain connectivity differences found in infants with congenital heart disease

The prevalence of congenital heart disease points to the need for a better understanding of how it influences neurodevelopment. New in JNeurosci, Jung-Hoon Kim and Catherine Limperopoulos, from Children's National Hospital, led a study examining brain network disruptions that may be linked to congenital heart disease.

9 Mar 2026

Scientists simulate complete life cycle of a minimal bacterial cell

By simulating the life cycle of a minimal bacterial cell - from DNA replication to protein translation to metabolism and cell division - scientists have opened a new frontier of computer vision into the essential processes of life.

9 Mar 2026

Exercise triggers memory-related brain waves in the hippocampus

A single session of physical exercise can spawn a boost of neural activity in brain networks that underlie learning and memory, according to a new study led by the University of Iowa.

9 Mar 2026

Microbial ecosystems influence success of cancer checkpoint immunotherapy

Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.

9 Mar 2026

Patients with advanced cancer want involvement in treatment decisions

Patients with advanced cancer should be involved in decisions about their own treatment. Yet, patients, and relatives and nurses too, are often unsure how exactly this should take place, according to a new doctoral thesis from the University of Agder (UiA).

9 Mar 2026

STING agonists exert potent antitumor effects against nervous system tumors

The cGAS-STING signaling pathway has emerged as a major focus in cancer immunotherapy because it stimulates interferon production and enhances antitumor immune responses.

9 Mar 2026

Boron neutron capture therapy shows promise for deadly brain tumors

Malignant gliomas are among the deadliest brain cancers, with limited treatment options and poor survival.

9 Mar 2026

$Biomimetic platform enhances CAR T therapy for relapsed and refractory leukemia$

Biomimetic platform enhances CAR T therapy for relapsed and refractory leukemia

Chimeric antigen receptor T (CAR T) cell therapy represents a milestone in leukemia treatment. CAR T works by genetically engineering a chimeric antigen receptor on the surface of the patient's T cells to target specific antigens on leukemia cells, with the goal of identifying and eliminating them.

9 Mar 2026

Cellular roadmap offers new targets for improving rotator cuff surgical repair

Rotator cuff tears are among the most common and debilitating musculoskeletal injuries, frequently causing chronic pain, reduced shoulder mobility, and a high risk of re-injury even after surgical repair.

9 Mar 2026

Adult stimulant prescriptions more than doubled since the start of the pandemic

New prescriptions for stimulants among adults, largely to treat ADHD, more than doubled since the start of the COVID-19 pandemic, especially in younger adults, found new research published in CMAJ.

9 Mar 2026

Taking anticoagulants alongside prostate cancer drugs does not increase bleeding risk

In a study of adults with advanced prostate cancer taking androgen-receptor pathway inhibitors and different types of anticoagulants, investigators found no evidence of an increase in patients' bleeding or clotting risks, despite previous lab results that raised alarms.

9 Mar 2026

FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy

Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy.

9 Mar 2026

Targeting Wnt signaling to solve the dental pulp challenge

Dental pulp regeneration remains a major clinical challenge. Researchers have discovered that SMAD7 directly forms a transcriptional complex with β-catenin in human dental pulp stem cells, activating Wnt signaling and promoting regenerative gene expression.

9 Mar 2026