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Chemotherapy for brain tumors is boosted after vaccine targets resistance-related TRP-2 antigen

In the August issue of the journal Oncogene, researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute describe a molecular mechanism that appears to make malignant brain tumors more vulnerable to chemotherapy after they have been treated with the dendritic cell vaccine.

13 Jun 2005

Researchers discover how microRNA are involved in the development of heart muscle

Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA - a chemical cousin of DNA - helps fine tune the production of a key protein involved in the early development of heart muscle.

12 Jun 2005

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Using targeted RNA interference, or RNAi libraries, researchers at Harvard Medical School describe the first large-scale classification of kinase and phosphatase gene families on the basis of their role in apoptosis and cell survival. This study appears in the June issue of Nature Cell Biology.

10 Jun 2005

Researchers explain how ubiquitin function is determined

University of Maryland researchers have explained, for the first time, why the linkage between the cell-regulating protein molecules called ubiquitins determines their function.

10 Jun 2005

Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

The finding, reported in the June 9 issue of Science Express, will allow scientists to study every stage of the HCV life cycle and develop drugs to treat this life-threatening disease that affects more than 170 million people around the world.

9 Jun 2005

Experimental drug works best in combination with older remedy for Alzheimer's disease and other dementias

An experimental drug combined with an already-popular memory-enhancing compound may further delay memory loss in patients with Alzheimer's disease and other dementias, Johns Hopkins University scientists, in collaboration with researchers from University of North Carolina, have found.

9 Jun 2005

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Making new strides in their ongoing effort to understand mechanisms behind the relentless growth of cancer cells, researchers at Dartmouth Medical School have found a promising key that may open doors to future treatments in pancreatic and other forms of cancer.

9 Jun 2005

Fundamental insights in how amyloid fibers form

Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt-Jacob disease--the human analog of mad cow disease.

9 Jun 2005

Helmholtz Institute develops a new path to more effective antibiotics

Resistance to antibiotics has increased alarmingly in recent years. For example, in France the resistance of pneumococci has risen to 58% due to high rates of antibiotic prescription. Medical experts are sounding the alarm. Pharmacologists are seeking new antibiotically effective substances.

6 Jun 2005

Test accurately predicts aggressiveness of breast cancer

A test that measures how quickly cells are dividing is an accurate way for doctors to predict the aggressiveness of breast cancer tumors, even among women with very early stages of the disease, researchers told the 2nd ESMO Scientific & Educational Conference (ESEC) in Budapest, Hungary.

6 Jun 2005

Vaccine targets tumors where they live

Vaccine strategies are being designed to battle cancer, but their use for metastatic melanoma is a challenge.

3 Jun 2005

A protein found naturally in the brain may protect against Parkinson's disease

The findings also may lead to an improved understanding of a disorder called early-onset torsion dystonia.

2 Jun 2005

Researcher develops compounds to control bacteria

A method for controlling bacterial activity without antibiotics by interfering with their communication process has been developed by a young Hebrew University of Jerusalem researcher.

2 Jun 2005

Scientists have uncovered the structure of a network of proteins that help regulate the life cycle of cells

Scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have uncovered the structure of a network of proteins that help regulate the life cycle of cells. Understanding the network's physical layout is an important step toward learning its precise function, and in finding ways to correct flaws in the system that could lead to cancer.

2 Jun 2005

The bacteria that cause food poisoning, bubonic plague, and whooping cough all deploy the same weapon to infect the body

A molecular "syringe" sticks out of the bacteria, pokes a hole in a nearby cell, and squirts in venomous proteins that hijack the cell's machinery.

2 Jun 2005

Scientists shed new light on how protein Ro creates RNA quality control system for cells

A report by Yale scientists in the journal Cell sheds new light on how the protein Ro, a major autoantigen in patients with autoimmune disease, recognizes misfolded RNAs, creating a RNA quality control system for cells.

1 Jun 2005

New clue to understanding how fatty acids work in the brain

Scientists in Cambridge have discovered that a brain protein called syntaxin enables fatty molecules, used widely in health supplements, to work in the brain to make it function properly. Lead Scientist, Dr Bazbek Davletov and his colleague Dr Colin Rickman from the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, UK report their findings in the journal Chemistry and Biology.

1 Jun 2005

Newly discovered gene could provide targets for diabetes therapies

The Juvenile Diabetes Research Foundation (JDRF) has announced that JDRF-funded researchers in Australia and the United Kingdom have identified a gene called Roquin that regulates the immune system and keeps harmful T cells in check.

1 Jun 2005

Targepeutics issued new U.S patent

Targepeutics has announced the issuance of U.S. Patent No. 6,884,603 for its genetically modified, mutated Interleukin 13 (IL-13) technology platform for the treatment of malignant glioma, a brain tumor (17,500 people annually; $200 million annual market).

31 May 2005

Artificial cobweb proteins for medicine

A unique material based on cobweb proteins is being created by Russian researchers of the State Research Center of Russian Federation GosNIIgentics, Scientific Research Center “Coal-Chemical Fiber”, State Research Center of Applied Microbiology in cooperation with their colleagues from Michigan University with support form the International Science and Technology Center (ISTC) (project 1033.2).

30 May 2005

Molecule News and Research

Chemotherapy for brain tumors is boosted after vaccine targets resistance-related TRP-2 antigen

Researchers discover how microRNA are involved in the development of heart muscle

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

Researchers explain how ubiquitin function is determined

Scientists produce for the first time an infectious form of the hepatitis C virus in laboratory cultures of human cells

Experimental drug works best in combination with older remedy for Alzheimer's disease and other dementias

Molecule called Smad7 may open doors to future treatments in pancreatic and other forms of cancer

Fundamental insights in how amyloid fibers form

Helmholtz Institute develops a new path to more effective antibiotics

Test accurately predicts aggressiveness of breast cancer

Vaccine targets tumors where they live

A protein found naturally in the brain may protect against Parkinson's disease

Researcher develops compounds to control bacteria

Scientists have uncovered the structure of a network of proteins that help regulate the life cycle of cells

The bacteria that cause food poisoning, bubonic plague, and whooping cough all deploy the same weapon to infect the body

Scientists shed new light on how protein Ro creates RNA quality control system for cells

New clue to understanding how fatty acids work in the brain

Newly discovered gene could provide targets for diabetes therapies

Targepeutics issued new U.S patent

Artificial cobweb proteins for medicine

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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