Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

The Role of Nanoparticles for Drug Delivery

In this interview, Mark Bumiller, Technology Manager at Entegris talks to News Medical Life Sciences about the role nanoparticles can play in drug delivery.

From Entegris, Inc. 15 Jun 2021

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

The liver is the most resilient organ in the human body. It can remove toxins from the bloodstream, recycle red blood cells, maintain sugar levels, and it can even regenerate itself. But, when a large amount of fat builds up in the liver, it becomes too inflamed to perform its crucial duties.

14 Jun 2021

SBP scientist receives $1.9 million from NHLBI for atrial fibrillation research

Sanford Burnham Prebys Assistant Professor Alexandre Colas has been awarded $1.9 million by the National Heart, Lung, and Blood Institute at the National Institutes of Health to discover drugs that restore normal cardiac rhythm in atrial fibrillation.

14 Jun 2021

PhoreMost appoints Christian Dillon as Vice President of Biology

PhoreMost Ltd today announced it has appointed Dr Christian Dillon as Vice President of Biology.

From PhoreMost 14 Jun 2021

Role of traditional medicine against SARS-CoV-2

A group of researchers at Kannur University reviewed selected papers and in silico work on potential drug leads that could be used to manage COVID-19.

13 Jun 2021

Structural analogs of triterpenoids show strong inhibitory activity against coronaviruses

In a recent study published in the journal Pathogens, researchers carried out a molecular docking study for 17 structural analogs prepared from natural maslinic and oleanolic acids and screened them against SARS-CoV-2 main protease. They also experimentally validated the data by determining the half-maximal cytotoxic and inhibitory concentrations of each of the 17 compounds. The researchers investigated whether the compound with antiviral activity affected viral adsorption, replication, or viricidal effect using a plaque infectivity reduction assay.

9 Jun 2021

FDA approves monoclonal antibody aducanumab for treating Alzheimer's patients

Today's FDA approval of the monoclonal antibody Aduhelm (aducanumab) to treat patients with Alzheimer's disease reflects years of significant advances in Alzheimer's research. This is the first new Alzheimer's drug approved in 17 years and the first shown to modify the course of the disease, which FDA believes will lead to slowing of patients' cognitive decline.

8 Jun 2021

Autobahn Labs collaborates with CSHL to advance science from the lab to clinic

Autobahn Labs, an early-stage drug discovery incubator, today announced a new strategic venture collaboration with Cold Spring Harbor Laboratory.

7 Jun 2021

Gene therapy may be a safe and effective single-dose treatment for soft bone disease

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10--a gene therapy that replaces a key enzyme found in bone--may be a safe and effective single-dose treatment for hypophosphatasia (HPP).

7 Jun 2021

Rice scientist wins NIH grant to model and analyze protein-ligand interactions in cancer research

Computer scientist Lydia Kavraki of Rice University's Brown School of Engineering has won a prestigious National Institutes of Health U01 grant to develop a new approach to model and analyze protein-ligand interactions in cancer research.

7 Jun 2021

Sphere Fluidics and ClexBio introduce CYTRIX Microfluidic Hydrogel Kit

Sphere Fluidics, a company commercializing single cell analysis systems underpinned by its patented picodroplet technology, and ClexBio, a pioneer in solutions for tissue engineering and single-cell techniques, today announced the launch of the biocompatible CYTRIX Microfluidic Hydrogel Kit.

From Fluidic Sciences and Sphere Bio 7 Jun 2021

Researchers identify a novel link between aging, metabolism and anti-cancer T-cell function

MUSC Hollings Cancer Center researchers are finding solutions to the aging-related changes that reduce anti-cancer immunity. Besim Ogretmen, Ph.D., and colleagues found a novel link between aging, metabolism and anti-cancer T-cell function. Their work, published in Cell Reports, sheds light on an important pathway that cannot be ignored during cancer treatment.

4 Jun 2021

Research opens alternative therapeutic avenues for treatment of chronic pain

Building on previous findings, scientists have demonstrated that conolidine interacts with the newly identified opioid receptor ACKR3/CXCR7.

3 Jun 2021

Scientists identify many existing drugs with antiviral activity against coronavirus

Mining the world's most comprehensive drug repurposing collection for COVID-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.

3 Jun 2021

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

New research undertaken by researchers in the USA describes two parallel but distinct in vivo approaches for the accelerated discovery of antibodies targeting SARS-CoV-2 spike protein.

3 Jun 2021

Known pharmaceutical compounds could provide new therapies for COVID-19

After screening over 12,000 existing treatments, researchers have found many promising antiviral compounds that could treat COVID-19.

3 Jun 2021

New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

Researchers from Carnegie Mellon University's Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments.

3 Jun 2021

Pseudomonas aeruginosa poses a serious threat to human health

No one knows exactly when humans and pathogenic bacteria were encountered with each other. But since then, the war began over life and survival between them. During this time, both sides of the war tried to equip themselves with all their might.

2 Jun 2021

NUS researchers develop a way to automate the production of pharmaceutical small molecules

The discovery and development of new small-molecule compounds for therapeutic use involves a huge investment of time, effort and resources.

1 Jun 2021

Review: Sulfur-containing natural products isolated from marine organisms

Announcing a new publication for Marine Life Science & Technology journal. In this review article the authors Yang Hai, Mei‑Yan Wei, Chang‑Yun Wang, Yu‑Cheng Gu and Chang‑Lun Shao from Ocean University of China, Qingdao, China and Syngenta Jealott's Hill International Research Centre, Berkshire, UK consider the chemistry and biology of sulfur‑containing natural products from marine microorganisms.

31 May 2021

Drug Discovery News and Research

Further Reading

The Role of Nanoparticles for Drug Delivery

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

SBP scientist receives $1.9 million from NHLBI for atrial fibrillation research

PhoreMost appoints Christian Dillon as Vice President of Biology

Role of traditional medicine against SARS-CoV-2

Structural analogs of triterpenoids show strong inhibitory activity against coronaviruses

FDA approves monoclonal antibody aducanumab for treating Alzheimer's patients

Autobahn Labs collaborates with CSHL to advance science from the lab to clinic

Gene therapy may be a safe and effective single-dose treatment for soft bone disease

Rice scientist wins NIH grant to model and analyze protein-ligand interactions in cancer research

Sphere Fluidics and ClexBio introduce CYTRIX Microfluidic Hydrogel Kit

Researchers identify a novel link between aging, metabolism and anti-cancer T-cell function

Research opens alternative therapeutic avenues for treatment of chronic pain

Scientists identify many existing drugs with antiviral activity against coronavirus

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

Known pharmaceutical compounds could provide new therapies for COVID-19

New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

Pseudomonas aeruginosa poses a serious threat to human health

NUS researchers develop a way to automate the production of pharmaceutical small molecules

Review: Sulfur-containing natural products isolated from marine organisms

Event guide: World ADC San Diego eBook

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