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New study links intestinal protein to food allergy development

When is food simply nourishing and enjoyable, and when does it provoke an allergic reaction? The answer appears to lie in the balance of microbes that live in our intestine - and a specific protein secreted by intestinal goblet cells that influences that balance.

22 Jan 2025

Researchers construct a detailed structural map of GABAA receptors in the human brain

Certain proteins found in the human brain have long been known to be critical to controlling how brain cells communicate with each other.

22 Jan 2025

Genomic insights and new treatment paradigms related to HER2-low breast cancer

A new review was published in Oncotarget's Volume 16 on January 20, 2025, titled "Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms."

22 Jan 2025

Why do people with obesity, but without diabetes, start taking semaglutide?

Research identifies key factors affecting semaglutide initiation among obese individuals without diabetes, revealing significant insurance coverage disparities.

22 Jan 2025

Single dose of novel drug shows tumor-clearing potential in breast cancer models

Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women.

22 Jan 2025

GLP1RA medications linked to behavioral side effects in type 2 diabetes and obesity

Glucagon-like peptide 1 receptor agonists (GLP1RA)-medications for type 2 diabetes and obesity that have recently been making headlines due to a rise in popularity as weight loss agents-have been linked with behavioral side effects.

22 Jan 2025

How gut microbiota impacts childhood obesity

Gut microbiota plays a critical role in childhood obesity by influencing energy metabolism, inflammation, and appetite regulation, with emerging therapeutic strategies like probiotics, dietary interventions, and fecal microbiota transplantation showing promise.

21 Jan 2025

Study finds anti-correlation of KLRG1 and PD-1 expression in tumor fighting T cells

A new research paper was published in Oncotarget's Volume 16 on January 20, 2025, titled "Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells."

21 Jan 2025

Research reveals sex differences in microglia response to injury

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another "crew" of responders is busy clearing debris and repairing injured tissue.

21 Jan 2025

Research shows epigenetic aging in the blood as potential breast cancer marker

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled "DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility."

21 Jan 2025

Benefits and risks of popular weight-loss drugs revealed

Demand for weight-loss medications sold under brand names such as Ozempic and Wegovy continues to surge, with a recent study reporting one in eight Americans has taken or is currently using the drugs to treat diabetes, heart disease or obesity.

20 Jan 2025

Researchers create an atlas of health associations for GLP-1 receptor agonists

Insights from a study on GLP-1 receptor agonists reveal benefits for cardiometabolic health, with notable risks for gastrointestinal and musculoskeletal issues.

20 Jan 2025

Intermuscular fat increases risk of heart disease independent of BMI

People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to research published in the European Heart Journal today (Monday).

20 Jan 2025

Antihistamines offer new hope for erythropoietic protoporphyria-related liver disease

Chlorcyclizine shows promise in reducing protoporphyrin-IX accumulation and liver damage in erythropoietic protoporphyria, targeting histamine pathways.

20 Jan 2025

Mapping neuronal IL-1R1 expression reveals insights into brain function

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased states.

17 Jan 2025

DDR2 enhances BMP-dependent bone regeneration and reduces heterotopic ossification

Bone loss resulting from trauma, fractures, or disease presents a major global health challenge, often leading to long-term disability.

17 Jan 2025

Inflammasome proteins found to prevent cancer by regulating stem cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025