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Gene decoding revealed at atomic level

A recent finding by a North Carolina State University biochemist advances the fundamental biology of how genetic information, encoded in DNA, is decoded for the production of proteins.

4 Dec 2004

Novel anti-obesity compound shows promise for treatment of obesity

Arena Pharmaceuticals announced today results from the dosing phase of its Phase 1b clinical trial of APD356, an orally administered small molecule designed to regulate satiety (and perhaps metabolism) for the treatment of obesity.

30 Nov 2004

Key molecule helps identify renal cell carcinoma

Mayo Clinic researchers have discovered a key molecule that lets doctors identify one of the most aggressive types of kidney cancer. Patients with renal cell carcinoma who have higher levels of a molecule known as B7-H1 in their tumors are nearly five times more likely to die from the disease than patients with low levels or an absence of the molecule.

30 Nov 2004

New trial to test cancer smart drugs

Cancer Research UK has launched a major new clinical trial for the most common form of lung cancer, to test the effectiveness of one of the new generation of 'smart' cancer drugs as a first line treatment.

29 Nov 2004

New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

Scientists have given blind nerve cells the ability to detect light

Scientists at the University of California, Berkeley, have given "blind" nerve cells the ability to detect light, paving the way for an innovative therapy that could restore sight to those who have lost it through disease.

24 Nov 2004

Crystals may help to revolutionise drug discovery

A groundbreaking technique developed at The University of Manchester, which uses crystals to map ‘invisible’ parts of molecules, is set to revolutionise drug discovery.

From The University of Manchester 24 Nov 2004

Cells linked to asthma and eczema also help cure deadly illness in mice

Mast cells are immune cells known mostly for their unwanted effects: they cause the wheezing of asthma, the itching of eczema, the sneezing and runny nose of hay fever and, in extreme cases, the life-threatening shock of anaphylaxis.

20 Nov 2004

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

This structure should prove extremely useful in the rational design of small molecule inhibitors of PKCÈ, which has been implicated in T-cell mediated disease processes including inflammation and autoimmunity.

19 Nov 2004

Research provides more evidence of communication between developing nerves and blood vessels

In a developing embryo, the growth of nerves cannot outpace the establishment of life-giving blood vessels. Now, researchers have found that a protein intimately involved in blood vessel patterning actually belongs to a family of proteins known to guide neural development.

18 Nov 2004

Sequencing of human genetic code promises to usher in a new era of genetic medicine

The ability of molecular biologists to sequence the human genetic code promises to usher in a new era of genetic medicine, but that doesn’t mean science can accurately read personal genetic codes.

16 Nov 2004

Mast cells can provide protection from a potentially deadly condition known as sepsis

14 Nov 2004

New studies demonstrate efficacy of novel Lipoxin analog in laboratory models of Crohn's disease

Berlex announced today that new laboratory results demonstrate that its modified version of the naturally occurring lipoxin molecule exerts potent anti-inflammatory and immunomodulatory effects in Crohn's disease in vivo models and may provide a promising new oral treatment.

9 Nov 2004

In a world first, Australian researchers re-grow cut spinal cord

In a world first, Australian researchers have discovered a mechanism for greatly enhancing regrowth of spinal cord nerves after they are damaged, restoring the ability to walk in mice within weeks of a spinal cord injury.

8 Nov 2004

New understanding of the role viruses play in the development of autoimmune diseases

Researchers at the La Jolla Institute for Allergy & Immunology have added a significant milestone to scientific understanding of the role viruses play in the development of autoimmune diseases, such as diabetes.

4 Nov 2004

Sensor protein that identifies DNA breaks and activates the p53 cell-death program has been identified

DNA breaks from radiation, toxic chemicals, or other environmental causes occur routinely in cells and, unless promptly and properly repaired, can lead to cancer-causing mutations.

4 Nov 2004

STAT3 protein could lead to new ways to prevent skin cancer

Scientists at The University of Texas M. D. Anderson Cancer Center have identified a protein that serves as a master regulator of skin cancer - a finding that could lead to new ways to prevent skin cancer before it starts.

4 Nov 2004

Gene regulated by need to process proteins linked to enlargement of protein processing factory

Part of a cellular mechanism that regulates the folding of new proteins into their proper shapes also includes a genetic response that enlarges the factory where both protein folding and packaging of proteins occurs.

2 Nov 2004

Diabetic or obese patients suffering advanced heart failure have higher levels of fat embedded in their hearts

Heart failure, progressive and potentially fatal weakening of the heart muscle, is associated with both obesity and diabetes, but the mechanisms by which damage occurs are not well-understood, said senior author Heinrich Taegtmeyer, M.D., Ph.D., professor of cardiology.

1 Nov 2004

Researchers provide concrete evidence about how the human eye evolved

When Darwin's skeptics attack his theory of evolution, they often focus on the eye. Darwin himself confessed that it was "absurd" to propose that the human eye, an "organ of extreme perfection and complication" evolved through spontaneous mutation and natural selection.

1 Nov 2004

Molecule News and Research

Gene decoding revealed at atomic level

Novel anti-obesity compound shows promise for treatment of obesity

Key molecule helps identify renal cell carcinoma

New trial to test cancer smart drugs

New research may lead to treatments for atherosclerosis

Scientists have given blind nerve cells the ability to detect light

Crystals may help to revolutionise drug discovery

Cells linked to asthma and eczema also help cure deadly illness in mice

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

Research provides more evidence of communication between developing nerves and blood vessels

Sequencing of human genetic code promises to usher in a new era of genetic medicine

Mast cells can provide protection from a potentially deadly condition known as sepsis

New studies demonstrate efficacy of novel Lipoxin analog in laboratory models of Crohn's disease

In a world first, Australian researchers re-grow cut spinal cord

New understanding of the role viruses play in the development of autoimmune diseases

Sensor protein that identifies DNA breaks and activates the p53 cell-death program has been identified

STAT3 protein could lead to new ways to prevent skin cancer

Gene regulated by need to process proteins linked to enlargement of protein processing factory

Diabetic or obese patients suffering advanced heart failure have higher levels of fat embedded in their hearts

Researchers provide concrete evidence about how the human eye evolved

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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