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Replication timing assays may allow much earlier cancer detection

Scientists have discovered a DNA sequence that is involved in controlling the timing of DNA replication. Because alterations in DNA replication timing are associated with cancer, this discovery may lead to improved methods for cancer detection.

26 Sep 2004

Promising lead in developing anti-viral drugs with the potential to fight HIV and HSV

Dr Norelle Daly, from UQ’s Institute for Molecular Bioscience, is looking at the molecular structure of retrocyclin, a molecule with the ability to protect human cells from HIV infection.

23 Sep 2004

Research may lead to alternatives to antibiotic drugs for treating bacterial diseases

UCLA microbiologists report the discovery of a new class of genetic elements, similar to retroviruses, that operate in bacteria, allowing them to diversify their proteins to bind to a large variety of receptors.

23 Sep 2004

Potential new way to control drug-resistant bacteria

The researchers, who encountered this genetic property while working on an unrelated project, believe that this discovery could lead to the use of genetically engineered phages to treat bacterial infections that have become resistant to antibiotics.

23 Sep 2004

Research to halt the progress of chronic liver disease

A University of Queensland researcher is working to halt the progress of chronic liver disease, which affects a quarter of million Australians.

22 Sep 2004

Novel strategy for stimulating the production of utrophin

Researchers at the University of Pennsylvania School of Medicine report a novel strategy for stimulating the production of utrophin – an important muscle protein in young mice – for muscular dystrophy therapy.

21 Sep 2004

Scientists have corrected a flaw in cancer cells that lets them evade the normal cell-death process

Scientists at Dana-Farber Cancer Institute have corrected a flaw in cancer cells that lets them evade the normal cell-death process, and as a result they eliminated leukemia cells from mice.

21 Sep 2004

Certain cancers might one day be cured without the use of toxic chemotherapy and radiation

The eradication of brain tumors in mice following treatment with a novel drug suggests that certain cancers might one day be cured without the use of toxic chemotherapy and radiation.

20 Sep 2004

Data suggests potential role of Quadramet in conjunction with chemotherapy for the treatment of acute myeloid leukemia

Cytogen Corporation today announced the presentation of new data relating to its lead therapeutic product Quadramet (samarium Sm-153 lexidronam injection) during the 36th Congress of the International Society of Pediatric Oncology (SIOP).

20 Sep 2004

Isis Pharmaceuticals licenses second anti-cancer drug candidate to Lilly

Isis Pharmaceuticals announced today that Eli Lilly and Company licensed LY2275796, a second-generation antisense anti-cancer drug candidate for clinical development.

20 Sep 2004

Tarceva plus Gemcitabine improves survival compared to Gemcitabine alone

OSI Pharmaceuticals, Inc., Genentech, Inc., and Roche announced today that results from a randomized Phase III clinical study of the investigational drug Tarceva (erlotinib HCl), in combination with gemcitabine chemotherapy met its primary endpoint of improving survival.

20 Sep 2004

Breakthrough in spinal regeneration research

University of Queensland researchers are claiming a breakthrough in spinal regeneration research with the discovery of a molecule that blocks regrowth of damaged nerve processes.

20 Sep 2004

Resveratrol in red wine, is thought to contribute to improved cardiovascular effects associated with moderate consumption of red wine

Researchers funded by the National Science Foundation (NSF) and affiliated with the Salk Institute in San Diego, Calif., have succeeded in converting chalcone synthase, a biosynthetic protein enzyme found in all higher plants, into an efficient resveratrol synthase.

20 Sep 2004

Protein points to anticancer drug targets

A unique tail at one end of a protein called Ubc12 stabilizes a molecular workshop that assembles the “on-switch cells” used to accelerate cell replication.

20 Sep 2004

Jellyfish advance science

Salmon fishermen trolling along the waters off Puget Sound in Washington are often witness to an awesome sight when they haul in their catch: salmon captured in nets that glow brilliantly against the nighttime sky.

16 Sep 2004

Surprise finding about male infertility

CANCER Research UK scientists have made a surprise finding about the molecular basis of male infertility, reporting their results in the current edition of Nature.

16 Sep 2004

Protein that causes juvenile Batten disease also plays a key role in normal cell function

The aberrant protein that causes juvenile Batten disease, a fatal neurodegenerative disorder of childhood, also plays a key role in normal cell function, Duke University Medical Center researchers have found.

16 Sep 2004

Immunoglobulins might be promising treatment for Alzheimer's disease

Intravenous immunoglobulin might offer a promising treatment for Alzheimer's disease, suggests preliminary research in the Journal of Neurology Neurosurgery and Psychiatry.

15 Sep 2004

First molecular-scale images of DNA binding to an adenovirus enzyme

The images, which appear on the cover of the October 2004 issue of Molecular and Cellular Proteomics, show how binding to DNA may stimulate the enzyme and are already being used to design new antiviral drugs to block this interaction.

14 Sep 2004

Molecule that may be a primary cause of high blood pressure and link to diabetes

A study published in this week's Proceedings of the National Academy of Sciences identified the molecule that binds to a receptor (a molecule on the cell surface that triggers a reaction within the cell) in the brain that is known to regulate blood pressure and release of insulin.

14 Sep 2004

Molecule News and Research

Replication timing assays may allow much earlier cancer detection

Promising lead in developing anti-viral drugs with the potential to fight HIV and HSV

Research may lead to alternatives to antibiotic drugs for treating bacterial diseases

Potential new way to control drug-resistant bacteria

Research to halt the progress of chronic liver disease

Novel strategy for stimulating the production of utrophin

Scientists have corrected a flaw in cancer cells that lets them evade the normal cell-death process

Certain cancers might one day be cured without the use of toxic chemotherapy and radiation

Data suggests potential role of Quadramet in conjunction with chemotherapy for the treatment of acute myeloid leukemia

Isis Pharmaceuticals licenses second anti-cancer drug candidate to Lilly

Tarceva plus Gemcitabine improves survival compared to Gemcitabine alone

Breakthrough in spinal regeneration research

Resveratrol in red wine, is thought to contribute to improved cardiovascular effects associated with moderate consumption of red wine

Protein points to anticancer drug targets

Jellyfish advance science

Surprise finding about male infertility

Protein that causes juvenile Batten disease also plays a key role in normal cell function

Immunoglobulins might be promising treatment for Alzheimer's disease

First molecular-scale images of DNA binding to an adenovirus enzyme

Molecule that may be a primary cause of high blood pressure and link to diabetes

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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