Protein C News and Research

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Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21.

17 Sep 2020

Study shows why bacterial cells behave differently on different types of surfaces

These results from studies in both experimental and theoretical physics may help to improve antibacterial surfaces. The research work was recently published in the journal 'Nanoscale'.

17 Sep 2020

Powerful 2D FFF system opens up new routes for separations

Postnova Analytics powerful EAF4 technology combines the principle of Electrical and Asymmetrical Flow Field-Flow Fractionation in just one system.

From Postnova Analytics 17 Sep 2020

Blood viscometers could help guide the treatment of Covid-19 patients

One of the biggest challenges facing medical teams treating Covid-19 patients is identifying which ones are likely to suffer the most extreme responses to the virus.

17 Sep 2020

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

In a study published on the bioRxiv preprint server, researchers from the University of Pécs, University of Vienna, and CEBINA GmbH, Vienna, show the ability of the antihistamine azelastine to inhibit SARS-CoV-2 infection in human nasal tissue in vitro.

16 Sep 2020

Point-of-care biomarker assay predicts traumatic brain injury in minutes

Intracranial abnormalities on CT scan in patients with traumatic brain injury (TBI) can be predicted by glial fibrillary acidic protein (GFAP) levels in the blood.

16 Sep 2020

A ferry protein in the pancreas safeguards beta-cells from high-fat diet induced stress

Every time we eat, the glucose level in our body goes up. This spurs our pancreatic machinery into action and through intricate physiological mechanisms, appropriate amounts of insulin are produced, our blood glucose levels are controlled, and we remain healthy.

16 Sep 2020

Researchers uncover how vitamin E acetate might cause lung injury in vapers

E-cigarette, or vaping, associated lung injury (EVALI) has sickened thousands of people, most under the age of 35.

16 Sep 2020

Study implicates new gene as driver of motor neuron diseases

Failures in a quality control system that protects protein-building fidelity in cells can lead to motor neuron degeneration and related diseases, according to a new study from an international team co-directed by Scripps Research molecular biologist Claudio Joazeiro, PhD.

16 Sep 2020

Researchers compare developed carriers for delivery of genome editing tools with existing analogs

Researchers from Peter the Great St.Petersburg Polytechnic University in collaboration with colleagues from the Pavlov University, ITMO University, and the University of Hamburg compared their developed carriers for delivery of genome editing (GE) tools with other available analogs.

16 Sep 2020

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Heart development as it happens in vivo, or in a living organism, is a complex process that has traditionally been difficult to mimic in vitro, or in the laboratory.

16 Sep 2020

Conditions linked to obesity leave the lungs of obese patients more susceptible to COVID-19

Conditions related to obesity, including inflammation and leaky gut, leave the lungs of obese patients more susceptible to COVID-19 and may explain why they are more likely to die from the disease, UTSW scientists say in a new article published online in eLife.

16 Sep 2020

SARS-CoV-2 with D614G mutation is prevalent in central India

A team of scientists at the Defence Research and Development Establishment, India, reveals that there are multiple viral introduction events in central India, and SARS-CoV-2 with D614G mutation is the prevalently circulating strain.

16 Sep 2020

Self-assembling nanoparticles as a way towards next-generation COVID-19 vaccines

In a promising study by US researchers, the receptor-binding domain (RBD) and stabilized spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were displayed on nanoparticles as vaccine antigens and elicited potent immune responses.

16 Sep 2020

Candidate monoclonal antibody shows hope as COVID-19 treatment

Researchers in the United States have described the effectiveness of a candidate monoclonal antibody currently being evaluated in a Phase 1 trial as a therapy for coronavirus disease 2019 (COVID-19) and its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Sep 2020

Study uncovers new markers present on melanoma tumors

A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma.

16 Sep 2020

Study provides insight into lymphomagenesis and patterns of resistance to immunotherapy

Lymphomas are a diverse group of cancers of the immune system, which is the body's primary defense against autoimmune disease, infections, and malignancy.

16 Sep 2020

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Now, a new study by researchers from Pfizer, University of Arizona, Purdue University, The Scripps Research Institute, and UC San Diego School of Medicine and published on the preprint server bioRxiv in September 2020 reports that an enzyme inhibitor may act in synergism with the approved antiviral remdesivir to suppress viral replication in COVID-19.

16 Sep 2020

Researchers develop protein-based biosensor for multiplex imaging of neurotransmitter

In 2018, Lin Tian and her team at UC Davis Health developed dLight1, a single fluorescent protein-based biosensor. This family of highly specific sensors detects dopamine, a hormone released by neurons to send signals to other nerve cells.

16 Sep 2020

Heparan sulfate aids COVID-19 virus to penetrate human lung cells

A molecule known as ACE2 sits like a doorknob on the outer surfaces of the cells that line the lungs. Since January 2020, researchers have known that SARS-CoV-2, the novel coronavirus that causes COVID-19, primarily uses ACE2 to enter these cells and establish respiratory infections.

16 Sep 2020

Protein C News and Research

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

Study shows why bacterial cells behave differently on different types of surfaces

Powerful 2D FFF system opens up new routes for separations

Blood viscometers could help guide the treatment of Covid-19 patients

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

Point-of-care biomarker assay predicts traumatic brain injury in minutes

A ferry protein in the pancreas safeguards beta-cells from high-fat diet induced stress

Researchers uncover how vitamin E acetate might cause lung injury in vapers

Study implicates new gene as driver of motor neuron diseases

Researchers compare developed carriers for delivery of genome editing tools with existing analogs

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Conditions linked to obesity leave the lungs of obese patients more susceptible to COVID-19

SARS-CoV-2 with D614G mutation is prevalent in central India

Self-assembling nanoparticles as a way towards next-generation COVID-19 vaccines

Candidate monoclonal antibody shows hope as COVID-19 treatment

Study uncovers new markers present on melanoma tumors

Study provides insight into lymphomagenesis and patterns of resistance to immunotherapy

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Researchers develop protein-based biosensor for multiplex imaging of neurotransmitter

Heparan sulfate aids COVID-19 virus to penetrate human lung cells

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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